A clinical trial alert tool to recruit large patient samples and assess selection bias in general practice research

BMC Medical Research Methodology

Volumn 11, Issue , 2011, Pages

  Heinemann, Stephanie ^a,b   Thüring, Sabine ^a   Wedeken, Sven ^a   Schäfer, Tobias ^a   Scheidt Nave, Christa ^c   Ketterer, Mirko ^d   Himmel, Wolfgang ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b FULDA UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c ROBERT KOCH INSTITUTE   (Germany)

^d IT Choice   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; CLINICAL TRIAL (TOPIC); COMPUTER PROGRAM; EPIDEMIOLOGY; FEMALE; GENERAL PRACTICE; GENERAL PRACTITIONER; HEALTH SURVEY; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; NURSE; ORGANIZATION AND MANAGEMENT; OSTEOPOROSIS; PATIENT SELECTION; PROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; CLINICAL TRIALS AS TOPIC; ELIGIBILITY DETERMINATION; FEMALE; GENERAL PRACTICE; GENERAL PRACTITIONERS; HEALTH SURVEYS; HUMANS; MALE; MIDDLE AGED; NURSES; OSTEOPOROSIS; PATIENT SELECTION; PROSPECTIVE STUDIES; SAMPLING STUDIES; SELECTION BIAS; SOFTWARE;

EID: 79851516668     PISSN: None     EISSN: 14712288     Source Type: Journal    
DOI: 10.1186/1471-2288-11-16     Document Type: Article

References (30)

1. Surveys using general practice registers: who are the non-responders? D Pope P Croft, J Public Health Med 1996 18 6 12 8785078 (Pubitemid 26098525)
2. A qualitative evaluation of implementing a randomized controlled trial in general practice. H Prout C Butler P Kinnersley M Robling K Hood R Tudor-Jones, Fam Pract 2003 20 675 681 10.1093/fampra/cmg609 14701891 (Pubitemid 38054716)
3. Pragmatic trials in primary care. Methodological challenges and solutions demonstrated by the DIAMOND-study. GA Fransen CJ van Marrewijk S Mujakovic JW Muris RJ Laheij ME Numans,, et al. BMC Med Res Methodol 2007 7 16 10.1186/1471-2288-7-16 17451599
4. Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity. M Godwin L Ruhland I Casson S MacDonald D Delva R Birtwhistle,, et al. BMC Med Res Methodol 2003 3 28 10.1186/1471-2288-3-28 14690550
5. Participation and successful patient recruitment in primary care. NJ de Wit AO Quartero AP Zuithoff ME Numans, J Fam Pract 2001 50 976 11711015
6. Randomised trials in general practice - a New Zealand experience in recruitment. A Pearl S Wright G Gamble R Doughty N Sharpe, N Z Med J 2003 116 681 14657964
7. Factors affecting general practitioners' recruitment of patients into a prospective study. V Peto A Coulter A Bond, Fam Pract 1993 10 207 211 10.1093/fampra/10.2.207 8359613 (Pubitemid 23210386)
8. Conducting randomized trials in general practice: methodological and practical issues. E Ward M King M Lloyd P Bower K Friedli, Br J Gen Pract 1999 49 919 922 10818663 (Pubitemid 29504911)
9. Incentives and disincentives to participation by clinicians in randomised controlled trials. JM Rendell RK Merritt, Cochrane Database Syst Rev 2007 17443636
10. Practical aspects of conducting a pragmatic randomised trial in primary care: patient recruitment and outcome assessment. DA van der Windt BW Koes M van Aarst MA Heemskerk LM Bouter, Br J Gen Pract 2000 50 371 374 10897533 (Pubitemid 30245615)
11. Survey among 78 studies showed that Lasagna's law holds in Dutch primary care research. JC van der Wouden AH Blankenstein MJ Huibers DA van der Windt WA Stalman AP Verhagen, J Clin Epidemiol 2007 60 819 824 10.1016/j.jclinepi.2006. 11.010 17606178 (Pubitemid 46990809)
12. Effect of a clinical trial alert system on physician participation in trial recruitment. PJ Embi A Jain J Clark S Bizjack R Hornung CM Harris, Arch Intern Med 2005 165 2272 2277 10.1001/archinte.165.19.2272 16246994 (Pubitemid 41549924)
13. Development of an electronic health record-based Clinical Trial Alert system to enhance recruitment at the point of care. PJ Embi A Jain J Clark CM Harris, AMIA Annu Symp Proc 2005 231 235 16779036
14. Randomised studies in general practice: how to integrate the electronic patient record. G Mosis B Koes J Dieleman BC Stricker LJ van der MC Sturkenboom, Inform Prim Care 2005 13 209 213 16259861 (Pubitemid 41684089)
15. Comparison of electronic physician prompts versus waitroom case-finding on clinical trial enrollment. BL Rollman GS Fischer F Zhu BH Belnap, J Gen Intern Med 2008 23 447 450 10.1007/s11606-007-0449-0 18373143 (Pubitemid 351464868)
16. Recruiting family physicians and patients for a clinical trial: lessons learned. J Sellors R Cosby K Trim J Kaczorowski M Howard L Hardcastle,, et al. Fam Pract 2002 19 99 104 10.1093/fampra/19.1.99 11818358 (Pubitemid 34173283)
17. Prospective preference assessment: a method to enhance the ethics and efficiency of randomized controlled trials. SD Halpern, Control Clin Trials 2002 23 274 288 10.1016/S0197-2456(02)00191-5 12057879 (Pubitemid 34621208)
18. Non-response bias in a lifestyle survey. A Hill J Roberts P Ewings D Gunnell, J Public Health Med 1997 19 203 207 9243437 (Pubitemid 27316482)
19. Randomised controlled trials in general practice. M Pringle R Churchill, BMJ 1995 311 1382 1383 8520259
20. Effect on trend estimates of the difference between survey respondents and non-respondents: results from 27 populations in the WHO MONICA Project. H Tolonen A Dobson S Kulathinal, Eur J Epidemiol 2005 20 887 898 10.1007/s10654-005-2672-5 16284866 (Pubitemid 41609488)
21. Survey non-response in the Netherlands: effects on prevalence estimates and associations. AJ Van Loon M Tijhuis HS Picavet PG Surtees J Ormel, Ann Epidemiol 2003 13 105 110 10.1016/S1047-2797(02)00257-0 12559669 (Pubitemid 36143709)
22. Recruitment of practices in primary care research: the long and the short of it. F Goodyear-Smith D York H Petousis-Harris N Turner J Copp N Kerse,, et al. Fam Pract 2009
23. Strategies to improve recruitment to research studies. J Mapstone D Elbourne I Roberts, Cochrane Database Syst Rev 2007 R000013 17443634
24. GP Participation and Recruitment of Patients to RCTs: Lessons from Trials of Acupuncture and Exercise for Low Back Pain in Primary Care. SE Bell-Syer LN Thorpe K Thomas H Macpherson, Evid Based Complement Alternat Med 2008 18955352
25. Computerized recruiting for clinical trials in real time. DL Weiner AJ Butte PL Hibberd GR Fleisher, Ann Emerg Med 2003 41 242 246 10.1067/mem.2003.52 12548275 (Pubitemid 36158021)
26. Health services research in general practice. A new approach [in German]. W Himmel E Hummers-Pradier MM Kochen, Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2006 49 151 159 10.1007/s00103-005-1215-2 16429308 (Pubitemid 43796361)
27. German primary care doctors' awareness of osteoporosis and knowledge of national guidelines. R Chenot C Scheidt-Nave S Gabler MM Kochen W Himmel, Exp Clin Endocrinol Diabetes 2007 115 584 589 10.1055/s-2007-981454 17943692 (Pubitemid 350070928)
28. Participation in a quality of care study and consequences for generalizability of general practice research. D Wetzel W Himmel R Heidenreich E Hummers-Pradier MM Kochen A Rogausch,, et al. Fam Pract 2005 22 458 464 10.1093/fampra/cmi022 15814583 (Pubitemid 41487383)
29. Leveraging of open EMR architecture for clinical trial accrual. LB Afrin JC Oates CK Boyd MS Daniels, AMIA Annu Symp Proc 2003 16 20 14728125
30. Workflow to improve patient recruitment for clinical trials within hospital information systems - a case-study. M Dugas M Lange WE Berdel C Muller-Tidow, Trials 2008 9 2 10.1186/1745-6215-9-2 18186949