Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

BMC Medical Genetics

Volumn 12, Issue , 2011, Pages

  Joubert, Bonnie R ^a,c   Reif, David M ^a   Edwards, Stephen W ^a   Leiner, Kevin A ^b   Hudgens, Edward E ^a   Egeghy, Peter ^a   Gallagher, Jane E ^a   Hubal, Elaine C ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOOD ALLERGEN; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; IMMUNOGLOBULIN E; MEMBRANE PROTEIN; MS4A2 PROTEIN; UNCLASSIFIED DRUG; GLUTATHIONE S-TRANSFERASE M1; GLUTATHIONE TRANSFERASE; GSTP1 PROTEIN, HUMAN; IMMUNOGLOBULIN E RECEPTOR; MS4A2 PROTEIN, HUMAN;

ADOLESCENT; AFRICAN AMERICAN; ALLERGY; ALLERGY TEST; ARTICLE; ASTHMA; ATOPY; CHILD; CHROMOSOME 11; EOSINOPHILIA; ETHNICITY; FEMALE; GENE DELETION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; GENETIC VARIABILITY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; URBAN POPULATION; CROSS-SECTIONAL STUDY; EVALUATION; FOOD ALLERGY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HYPERSENSITIVITY; IMMEDIATE TYPE HYPERSENSITIVITY; RISK; RISK FACTOR; UNITED STATES;

ADOLESCENT; AFRICAN AMERICANS; ASTHMA; CHILD; CHROMOSOMES, HUMAN, PAIR 11; CROSS-SECTIONAL STUDIES; FEMALE; FOOD HYPERSENSITIVITY; GENETIC PREDISPOSITION TO DISEASE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HAPLOTYPES; HUMANS; HYPERSENSITIVITY; HYPERSENSITIVITY, IMMEDIATE; LINKAGE DISEQUILIBRIUM; MALE; MICHIGAN; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, IGE; RISK FACTORS; SEQUENCE DELETION; URBAN POPULATION;

EID: 79851512650     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-12-25     Document Type: Article

References (72)

1. Busse WW, Lemanske RF. Asthma. N Engl J Med 2001, 344(5):350-362. 10.1056/NEJM200102013440507, 11172168.
2. Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with asthma: genetic insights. Proc Am Thorac Soc 2007, 4(1):58-68. 10.1513/pats.200607-146JG, 2647616, 17202293.
3. Scirica CV, Celedon JC. Genetics of asthma: potential implications for reducing asthma disparities. Chest 2007, 132(5 Suppl):770S-781S. 10.1378/chest.07-1905, 17998341.
4. Joseph CL, Williams LK, Ownby DR, Saltzgaber J, Johnson CC. Applying epidemiologic concepts of primary, secondary, and tertiary prevention to the elimination of racial disparities in asthma. J Allergy Clin Immunol 2006, 117(2):233-240. quiz 241-232, 10.1016/j.jaci.2005.11.004, 1904504, 16461121.
5. Gao L, Tsai YJ, Grigoryev DN, Barnes KC. Host defense genes in asthma and sepsis and the role of the environment. Curr Opin Allergy Clin Immunol 2007, 7(6):459-467. 10.1097/ACI.0b013e3282f1fb9a, 17989521.
6. Peden DB. Influences on the development of allergy and asthma. Toxicology 2002, 181-182:323-328. 10.1016/S0300-483X(02)00301-3, 12505333.
7. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006, 7(2):95-100. 10.1038/sj.gene.6364284, 16395390.
8. Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. J Allergy Clin Immunol 2010, 125(2 Suppl 2):S81-94. 10.1016/j.jaci.2009.10.071, 20176270.
9. Vercelli D. Advances in asthma and allergy genetics in 2007. J Allergy Clin Immunol 2008, 122(2):267-271. 10.1016/j.jaci.2008.06.008, 18619666.
10. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008, 8(3):169-182. 10.1038/nri2257, 18301422.
11. Kleeberger SR, Peden D. Gene-environment interactions in asthma and other respiratory diseases. Annu Rev Med 2005, 56:383-400. 10.1146/annurev.med.56.062904.144908, 15660518.
12. Platts-Mills TA. Allergens and asthma. Allergy Proc 1990, 11(6):269-271. 10.2500/108854190778879729, 2292373.
13. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, Borish L. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995, 25(Suppl 2):74-78. discussion 95-76, 10.1111/j.1365-2222.1995.tb00428.x, 8590350.
14. Walley AJ, Cookson WO. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet 1996, 33(8):689-692. 10.1136/jmg.33.8.689, 1050705, 8863163.
15. Pinto LA, Stein RT, Ribeiro JD. Genetic associations with asthma and virus-induced wheezing: a systematic review. J Bras Pneumol 2009, 35(12):1220-1226. 10.1590/S1806-37132009001200010, 20126925.
16. de Faria IC, de Faria EJ, Toro AA, Ribeiro JD, Bertuzzo CS. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr (Rio J) 2008, 84(3):203-210. 10.2223/JPED.1783, 18425216.
17. Haller G, Torgerson DG, Ober C, Thompson EE. Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility. J Allergy Clin Immunol 2009, 124(6):1204-1209. e1209, 10.1016/j.jaci.2009.09.013, 19910025.
18. Basehore MJ, Howard TD, Lange LA, Moore WC, Hawkins GA, Marshik PL, Harkins MS, Meyers DA, Bleecker ER. A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol 2004, 114(1):80-87. 10.1016/j.jaci.2004.05.035, 15241348.
19. Walley AJ, Wiltshire S, Ellis CM, Cookson WO. Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits. Genomics 2001, 72(1):15-20. 10.1006/geno.2000.6435, 11247662.
20. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999, 20(5):976-983.
21. Vercelli D, Baldini M, Stern D, Lohman IC, Halonen M, Martinez F. CD14: a bridge between innate immunity and adaptive IgE responses. J Endotoxin Res 2001, 7(1):45-48.
22. Choi J, Callaway Z, Kim HB, Fujisawa T, Kim CK. The role of TNF-alpha in eosinophilic inflammation associated with RSV bronchiolitis. Pediatr Allergy Immunol 2010,
23. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002, 418(6896):426-430. 10.1038/nature00878, 12110844.
24. Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene 2002, 282(1-2):227-236. 10.1016/S0378-1119(01)00818-6, 11814695.
25. Lee JH, Park HS, Park SW, Jang AS, Uh ST, Rhim T, Park CS, Hong SJ, Holgate ST, Holloway JW, et al. ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy 2004, 34(6):860-865. 10.1111/j.1365-2222.2004.01977.x, 15196271.
26. Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol 2003, 112(4):717-722. 10.1016/S0091-6749(03)01939-0, 14564349.
27. Choi JH, Lee KW, Kim CW, Park CS, Lee HY, Hur GY, Kim SH, Hong CS, Jang AS, Park HS. The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. Int Arch Allergy Immunol 2009, 150(2):156-163. 10.1159/000218118, 19439981.
28. Movahedi M, Moin M, Gharagozlou M, Aghamohammadi A, Dianat S, Moradi B, Nicknam MH, Nikbin B, Amirzargar A. Association of HLA class II alleles with childhood asthma and Total IgE levels. Iran J Allergy Asthma Immunol 2008, 7(4):215-220.
29. Gao J, Lin Y, Qiu C, Liu Y, Ma Y. Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects. Chin Med J (Engl) 2003, 116(7):1078-1082.
30. Lara-Marquez ML, Yunis JJ, Layrisse Z, Ortega F, Carvallo-Gil E, Montagnani S, Makhatadze NJ, Pocino M, Granja C, Yunis E. Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Clin Exp Allergy 1999, 29(1):60-71. 10.1046/j.1365-2222.1999.00461.x, 10051703.
31. Juhn YJ, Kita H, Bagniewski SM, Weaver AL, Pankratz VS, Jacobson RM, Poland GA. Severity of childhood asthma and human leukocyte antigens type. J Asthma 2007, 44(3):163-168. 10.1080/02770900701209632, 17454332.
32. Kraft S, Rana S, Jouvin MH, Kinet JP. The role of the FcepsilonRI beta-chain in allergic diseases. Int Arch Allergy Immunol 2004, 135(1):62-72. 10.1159/000080231, 15316148.
33. Sharma S, Ghosh B. Promoter polymorphism in the MS4A2 gene and asthma in the Indian population. Int Arch Allergy Immunol 2009, 149(3):208-218. 10.1159/000199716, 19218813.
34. Sharma S, Nagarkatti R, C BR, Niphadkar PV, Vijayan V, Sharma SK, Ghosh B. A_16_C haplotype in the FcepsilonRIbeta gene confers a higher risk for atopic asthma in the Indian population. Clin Genet 2004, 66(5):417-425. 10.1111/j.1399-0004.2004.00333.x, 15479187.
35. Potaczek DP, Sanak M, Szczeklik A. Additive association between FCER1A and FCER1B genetic polymorphisms and total serum IgE levels. Allergy 2007, 62(9):1095-1096. 10.1111/j.1398-9995.2007.01446.x, 17686114.
36. Sayers EW, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, DiCuccio M, Edgar R, Federhen S, et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2009, (37 Database):D5-15.
37. Ercan H, Birben E, Dizdar EA, Keskin O, Karaaslan C, Soyer OU, Dut R, Sackesen C, Besler T, Kalayci O. Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma. J Allergy Clin Immunol 2006, 118(5):1097-1104. 10.1016/j.jaci.2006.08.012, 17088135.
38. Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 2006, 533(1-3):222-239. 10.1016/j.ejphar.2005.12.087, 16500642.
39. Minelli C, Granell R, Newson R, Rose-Zerilli MJ, Torrent M, Ring SM, Holloway JW, Shaheen SO, Henderson JA. Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data. Int J Epidemiol 2010, 2846443, 20032267.
40. Williams AH, Gallagher JE, Hudgens E, Johnson MM, Mukerjee S, Ozkaynak HA, Nea LM, et al. EPA observational studies of children's respiratory health in Detroit and Dearborn, Michigan. Proceedings Air & Waste Management Association's 102nd Annual Conference & Exhibition 2009,
41. Heidenfelder B, Johnson M, Hudgens E, Inmon J, Hamilton RG, Neas L, Gallagher JE. Increased plasma reactive oxidant levels and their relationship to blood cells, total IgE, and allergen-specific IgE levels in asthmatic children. J Asthma 2010, 47(1):106-111. 10.3109/02770900903435964, 20100030.
42. Chang MH, Lindegren ML, Butler MA, Chanock SJ, Dowling NF, Gallagher M, Moonesinghe R, Moore CA, Ned RM, Reichler MR, et al. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol 2009, 169(1):54-66. 10.1093/aje/kwn286, 2638878, 18936436.
43. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81(3):559-575. 10.1086/519795, 1950838, 17701901.
44. Purcell S. PLINK version 1.06. 2010, , http://pngu.mgh.harvard.edu/~purcell/plink/
45. Food Allergies: What you Need to Know. 2007, US UFDA., http://www.fda.gov/downloads/Food/ResourcesForYou/Consumers/UCM079428.pdf
46. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing. J Roy Stat Soc B Met 1995, 57(1):289-300.
47. R Development Core Team R: A Language and Environment for Statistical Computing. 2010, R Foundation for Statistical Computing, R Development Core Team., http://www.R-project.org/
48. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265. 10.1093/bioinformatics/bth457, 15297300.
49. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001, 68(4):978-989. 10.1086/319501, 1275651, 11254454.
50. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003, 73(5):1162-1169. 10.1086/379378, 1180495, 14574645.
51. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002, 70(2):425-434. 10.1086/338688, 384917, 11791212.
52. Cheng R, Ma JZ, Wright FA, Lin S, Gao X, Wang D, Elston RC, Li MD. Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers. Genetics 2003, 164(3):1175-1187. 1462627, 12871923.
53. Maldonado G, Greenland S. Simulation study of confounder-selection strategies. Am J Epidemiol 1993, 138(11):923-936.
54. De Miguel-Yanes JM, Shrader P, Sullivan LM, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PWF, D'Agostino RB, Cupples LA, et al. A Type 2 Diabetes (T2D) Genetic Risk Score Using 37 Single Nucleotide Polymorphisms (SNPs) Significantly Reclassifies T2D Risk beyond Clinical T2D Risk Factors. Diabetes 2010, 59:A334-A334.
55. Yiannakouris N. A Genetic Score for CHD Risk Prediction. J Nutrigenet Nutrige 2008, 1(6):280-281.
56. Dandona S, Roberts R. Creating a genetic risk score for coronary artery disease. Current Atherosclerosis Reports 2009, 11(3):175-181. 10.1007/s11883-009-0028-4, 19361348.
57. Pankow JS, Kao WH, North KE, Peacock JM, Folsom AR, Boerwinkle E. Prediction of type 2 diabetes by a genetic risk score: The ARIC study. Diabetes 2008, 57:A331-A332.
58. Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, Hunter DJ, Hu FB. Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med 2009, 150(8):541-550.
59. de Bakker PI, Burtt NP, Graham RR, Guiducci C, Yelensky R, Drake JA, Bersaglieri T, Penney KL, Butler J, Young S, et al. Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet 2006, 38(11):1298-1303. 10.1038/ng1899, 17057720.
60. He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 2010, 30(2):327-332. 10.1161/ATVBAHA.109.196196, 19910641.
61. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, Pankow JS, Devlin JJ, Willerson JT, Boerwinkle E. Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 2007, 166(1):28-35. 10.1093/aje/kwm060, 17443022.
62. Dandona S, Roberts R. Creating a genetic risk score for coronary artery disease. Curr Atheroscler Rep 2009, 11(3):175-181. 10.1007/s11883-009-0028-4, 19361348.
63. Shiffman D, Rowland CM, Sninsky JJ, Devlin JJ. Polymorphisms associated with coronary heart disease: better by the score. Curr Opin Mol Ther 2006, 8(6):493-499.
64. Horne BD, Anderson JL, Carlquist JF, Muhlestein JB, Renlund DG, Bair TL, Pearson RR, Camp NJ. Generating genetic risk scores from intermediate phenotypes for use in association studies of clinically significant endpoints. Ann Hum Genet 2005, 69(Pt 2):176-186. 10.1046/j.1469-1809.2005.00155.x, 15720299.
65. Gunjaca G, Boban M, Pehlic M, Zemunik T, Budimir D, Kolcic I, Lauc G, Rudan I, Polasek O. Predictive value of 8 genetic loci for serum uric acid concentration. Croat Med J 2010, 51(1):23-31. 10.3325/cmj.2010.51.23, 2829178, 20162742.
66. De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 2009, 8(12):1111-1119. 10.1016/S1474-4422(09)70275-3, 19879194.
67. Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM. Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis 2010,
68. Nishiyama C, Akizawa Y, Nishiyama M, Tokura T, Kawada H, Mitsuishi K, Hasegawa M, Ito T, Nakano N, Okamoto A, et al. Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy. J Immunol 2004, 173(10):6458-6464.
69. Ferreira MA, Zhao ZZ, Thomsen SF, James M, Evans DM, Postmus PE, Kyvik KO, Backer V, Boomsma DI, Martin NG, et al. Association and interaction analyses of eight genes under asthma linkage peaks. Allergy 2009, 64(11):1623-1628. 10.1111/j.1398-9995.2009.02091.x, 19824886.
70. Islam T, Berhane K, McConnell R, Gauderman WJ, Avol E, Peters JM, Gilliland FD. Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax 2009, 64(3):197-202. 10.1136/thx.2008.099366, 2738935, 18988661.
71. Timofeeva M, Kropp S, Sauter W, Beckmann L, Rosenberger A, Illig T, Jager B, Mittelstrass K, Dienemann H, Bartsch H, et al. Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. Int J Cancer 2010, 127(7):1547-1561.
72. Mathias RA, Freidhoff LR, Blumenthal MN, Meyers DA, Lester L, King R, Xu JF, Solway J, Barnes KC, Pierce J, et al. Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families. Genet Epidemiol 2001, 20(3):340-355. 10.1002/gepi.5, 11255243.