Double-blind, randomized, placebo-controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania

Journal of Affective Disorders

Volumn 129, Issue 1-3, 2011, Pages 327-331

  Amrollahi, Zohreh ^a   Rezaei, Farzin ^b   Salehi, Bahman ^c   Modabbernia, Amir Hossein ^a   Maroufi, Azad ^b   Esfandiari, Gholam Reza ^b   Naderi, Mehrangiz ^c   Ghebleh, Fariba ^c   Ahmadi Abhari, Seyed Ali ^a   Sadeghi, Majid ^a   Tabrizi, Mina ^d   Akhondzadeh, Shahin ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KURDISTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ARAK UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Lithium; Mania; Protein kinase C; Tamoxifen

Indexed keywords

LITHIUM; PLACEBO; TAMOXIFEN CITRATE;

ADULT; ARTICLE; BIPOLAR MANIA; BLURRED VISION; CONSTIPATION; DECREASED APPETITE; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; HAMILTON SCALE; HUMAN; INCREASED APPETITE; MALE; MOVEMENT (PHYSIOLOGY); NERVOUSNESS; OUTCOME ASSESSMENT; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; RIGIDITY; SIDE EFFECT; TREMOR; XEROSTOMIA;

ADULT; ANTIMANIC AGENTS; BIPOLAR DISORDER; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; LITHIUM COMPOUNDS; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; TAMOXIFEN; TIME FACTORS; TREATMENT OUTCOME;

EID: 79851512361     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2010.08.015     Document Type: Article

References (14)

1. S. Akhondzadeh, E.S. Emamian, A. Ahmadi-Abhari, O. Shabestari, and M. Dadgarnejad Is it time to have another look at lithium maintenance therapy in bipolar disorder? Prog. Neuropsychopharmacol. Biol. Psychiatry 23 1999 1011 1017 (Pubitemid 29468910)
2. S. Akhondzadeh, H. Mohajari, M.R. Mohammadi, and H. Amini Ritanserin as an adjunct to lithium and haloperidol for the treatment of medication-naive patients with acute mania: a double blind and placebo controlled trial BMC Psychiatry 19 2003 3 7
3. S. Akhondzadeh, M.R. Milajerdi, H. Amini, and M. Tehrani-Doost Allopurinol as an adjunct to lithium and haloperidol for treatment of patients with acute mania: a double-blind, randomized, placebo-controlled trial Bipolar Disord. 8 2006 485 489 (Pubitemid 44560222)
4. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders Fourth Edition 2000 American Psychiatric Association Washington, DC Text Revision
5. J.M. Bebchuk, C.L. Arfken, S. Dolan-Manji, J. Murphy, K. Hasanat, and H.K. Manji A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania Arch. Gen. Psychiatry 57 2000 95 97 (Pubitemid 30035669)
6. K.N. Chengappa, R.W. Baker, L. Shao, L.N. Yatham, M. Tohen, S. Gershon, and D.J. Kupfer Rates of response, euthymia and remission in two placebo-controlled olanzapine trials for bipolar mania Bipolar Disord. 5 2003 1 5 (Pubitemid 36621626)
7. N. DiazGranados, and C.A. Zarate Jr. A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder Curr. Psychiatry Rep. 10 2008 510 519
8. M. Hamilton A rating scale for depression J. Neurol. Neurosurg. Psychiatry 3 1960 62 66
9. S.R. Kay, A. Fiszbein, and L.A. Opler The positive and negative syndrome scale for schizophrenia Schizophr. Bull. 13 1987 261 276 (Pubitemid 18039085)
10. J. Kulkarni, K.A. Garland, A. Scaffidi, B. Headey, R. Anderson, A. de Castella, P. Fitzgerald, and S.R. Davis A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder Psychoneuroendocrinology 31 2006 543 547 (Pubitemid 43375956)
11. A. Yildiz, S. Guleryuz, D.P. Ankerst, D. Ongür, and P.F. Renshaw Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen Arch. Gen. Psychiatry 65 2008 255 263 (Pubitemid 351342442)
12. R.C. Young, J.T. Biggs, V.E. Ziegler, and D.A. Meyer A rating scale for mania: reliability, validity and sensitivity Br. J. Psychiatry 61 1978 638 642
13. C.A. Zarate, and H.K. Manji Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder CNS Drugs 23 2009 569 582
14. C.A. Zarate Jr., J.B. Singh, P.J. Carlson, J. Quiroz, L. Jolkovsky, D.A. Luckenbaugh, and H.K. Manji Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study Bipolar Disord. 9 2007 561