E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer

European Journal of Cancer

Volumn 47, Issue 4, 2011, Pages 631-639

  Corso, Giovanni ^a,b   Pedrazzani, Corrado ^a   Pinheiro, Hugo ^b   Fernandes, Eduardo ^c   Marrelli, Daniele ^a   Rinnovati, Andrea ^d   Pascale, Valeria ^a   Seruca, Raquel ^b,e   Oliveira, Carla ^b,e   Roviello, Franco ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF PORTO   (Portugal)

^c ROYAL MARSDEN HOSPITAL   (United Kingdom)

^d Unit of Surgery   (Italy)

^e University of Porto   (Portugal)

Author keywords

Diffuse gastric cancer; E cadherin; Early onset gastric cancer; Family history; Genetic screening; Germline mutations; Hereditary and sporadic cancer; Pathology; Promoter methylation; Second hit

Indexed keywords

GENOMIC DNA; UVOMORULIN;

ADULT; ARTICLE; CELL AGGREGATION; CELL INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA METHYLATION; EARLY CANCER; EPIGENETICS; EXON; FAMILY HISTORY; FEMALE; GENETIC SCREENING; GENETIC VARIABILITY; GERM LINE; HETEROZYGOSITY LOSS; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; ONSET AGE; PATHOGENICITY; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION; STOMACH CANCER; SYSTEMATIC REVIEW;

ADULT; CADHERINS; CELL ADHESION; DNA METHYLATION; EARLY DETECTION OF CANCER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GERM-LINE MUTATION; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; MUTATION, MISSENSE; NEOPLASM INVASIVENESS; STOMACH NEOPLASMS;

EID: 79851510776     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.10.011     Document Type: Article

References (64)

1. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Estimating the world cancer burden: Globocan 2000 Int J Cancer 94 2001 153 156 (Pubitemid 32911406)
2. C. La Vecchia, F. Lucchini, and E. Negri Trends of cancer mortality in Europe, 1955-1989: I. Digestive sites Eur J Cancer 28 1992 132 235
3. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Global cancer statistics, 2002 CA Cancer J Clin 55 2005 74 108 (Pubitemid 40372904)
4. J. Ferlay, D.M. Parkin, and E. Steliarova-Foucher Estimates of cancer incidence and mortality in Europe in 2008 Eur J Cancer 46 2010 765 781
5. E.M. El-Omar, M. Carrington, and W.H. Chow Interleukin-1 polymorphisms associated with increased risk of gastric cancer Nature 404 2000 398 402 (Pubitemid 30164342)
6. C. Figueiredo, J.C. Machado, and P. Pharoah Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma J Natl Cancer Inst 94 2002 1680 1687 (Pubitemid 35446836)
7. G. La Torre, G. Chiaradia, and F. Gianfagna Smoking status and gastric cancer risk: an updated meta-analysis of case-control studies published in the past ten years Tumori 95 2009 13 22
8. D. Palli, A. Russo, and L. Ottini Red meat, family history, and increased risk of gastric cancer with microsatellite instability Cancer Res 61 2001 5415 5419 (Pubitemid 32694920)
9. H. Brenner, G. Bode, and H. Boeing Helicobacter pylori infection among offspring of patients with stomach cancer Gastroenterology 118 2000 31 35 (Pubitemid 30020370)
10. B. Stewart, P. Kleihues, World cancer report: IARC Stomach cancer 2003 WHO-IRC Lyon 194 197
11. A.N. Milne, R. Sitarz, R. Carvalho, F. Carneiro, and G.J. Offerhaus Early onset gastric cancer: on the road to unraveling gastric carcinogenesis Curr Mol Med 7 2007 15 28 (Pubitemid 46322276)
12. J.B. Koea, M.S. Karpeh, and M.F. Brennan Gastric cancer in young patients: demographic, clinicopathological, and prognostic factors in 92 patients Ann Surg Oncol 7 2000 346 351 (Pubitemid 30397475)
13. R. Carvalho, A.N. Milne, and B.P. van Rees Early-onset gastric carcinomas display molecular characteristics distinct from gastric carcinomas occurring at a later age J Pathol 204 2004 75 83 (Pubitemid 39214484)
14. A.N. Milne, R. Carvalho, and F.M. Morsink Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers Mod Pathol 19 2006 564 572
15. K. Umeyama, M. Sowa, K. Kamino, Y. Kato, and K. Satake Gastric carcinoma in young adults in Japan Anticancer Res 2 1982 283 286 (Pubitemid 13156002)
16. A. Ramos-De la Medina, N. Salgado-Nesme, G. Torres-Villalobos, and H. Medina-Franco Clinicopathologic characteristics of gastric cancer in a young patient population J Gastrointest Surg 8 2004 240 244 (Pubitemid 38340597)
17. S. Lim, H.S. Lee, H.S. Kim, Y.I. Kim, and W.H. Kim Alteration of E-cadherin-mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers Histopathology 42 2003 128 136 (Pubitemid 36237844)
18. M. Mori, K. Sugimachi, and T. Ohiwa Early gastric carcinoma in Japanese patients under 30 years of age Br J Surg 72 1985 289 291 (Pubitemid 15090959)
19. T. Nakamura, T. Yao, Y. Niho, and M. Tsuneyoshi A clinicopathological study in young patients with gastric carcinoma J Surg Oncol 71 1999 214 219 (Pubitemid 29388016)
20. T.W. McGill, E.C. Downey, J. Westbrook, D. Wade, and J. de la Garza Gastric carcinoma in children J Pediatr Surg 28 1993 1620 1621 (Pubitemid 23360459)
21. C. Dellavecchia, A. Guala, and C. Olivieri Early onset of gastric carcinoma and constitutional deletion of 18p Cancer Genet Cytogenet 113 1999 96 99 (Pubitemid 29354103)
22. P. Guilford, J. Hopkins, and J. Harraway E-cadherin germline mutations in familial gastric cancer Nature 392 1998 402 405 (Pubitemid 28168738)
23. G. Suriano, M.J. Oliveira, and D. Huntsman Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands Hum Mol Genet 12 2003 575 582 (Pubitemid 36305595)
24. C. Oliveira, J. Senz, and P. Kaurah Germline CDH1 deletions in hereditary diffuse gastric cancer families Hum Mol Genet 18 2009 1545 1555
25. C. Caldas, F. Carneiro, and H.T. Lynch Familial gastric cancer: overview and guidelines for management J Med Genet 36 1999 873 880 (Pubitemid 30003842)
26. R.C. Fitzgerald, R. Hardwick, and D. Huntsman Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research J Med Genet 47 2010 436 444
27. F. Carneiro, C. Oliveira, and R. Seruca Pathology and genetics of familial gastric cancer Int J Surg Pathol 18 2010 33S 36S
28. C. Pedrazzani, G. Corso, D. Marrelli, and F. Roviello E-cadherin and hereditary diffuse gastric cancer Surgery 142 2007 645 657 (Pubitemid 350018845)
29. P. Lauren The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification Acta Pathol Microbiol Scand 64 1965 31 49
30. C. Oliveira, P. Ferreira, and S. Nabais E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients Eur J Cancer 40 2004 1897 1903 (Pubitemid 39036766)
31. C. Oliveira, S. Sousa, and H. Pinheiro Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression Gastroenterology 136 2009 2137 2148
32. C. Oliveira, J. de Bruin, and S. Nabais Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour Oncogene 23 2004 2236 2240 (Pubitemid 38482539)
33. G. Suriano, S. Seixas, J. Rocha, and R. Seruca A model to infer the pathogenic significance of CDH1 germline missense variants J Mol Med 84 2006 1023 1031
34. M. Takeichi Cadherin cell adhesion receptors as a morphogenetic regulator Science 251 1991 1451 1455 (Pubitemid 121000430)
35. M. Takeichi Cadherins in cancer: implications for invasion and metastasis Curr Opin Cell Biol 5 1993 806 811
36. G. Christofori, and H. Semb The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene Trends Biochem Sci 24 1999 73 76 (Pubitemid 29346577)
37. K.F. Becker, M.J. Atkinson, and U. Reich E-cadherin gene mutations provide clues to diffuse type gastric carcinomas Cancer Res 54 1994 3845 3852 (Pubitemid 24241205)
38. J.C. Machado, C. Oliveira, and R. Carvalho E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma Oncogene 20 2001 1525 1528 (Pubitemid 32291203)
39. P.J. Guilford, J.B. Hopkins, and W.M. Grady E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer Hum Mutat 14 1999 249 255 (Pubitemid 29407266)
40. J.T. Bacani, M. Soares, and R. Zwingerman CDH1/E-cadherin germline mutations in early-onset gastric cancer J Med Genet 43 2006 867 872 (Pubitemid 44787113)
41. G. Keller, H. Vogelsang, and I. Becker J Med Genet 41 2004 e89
42. G. Suriano, S. Yew, and P. Ferreira Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management Clin Cancer Res 11 2005 5401 5409 (Pubitemid 41060814)
43. A.R. Brooks-Wilson, P. Kaurah, and G. Suriano Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria J Med Genet 41 2004 508 517 (Pubitemid 38932110)
44. T.C. Windham, P.M. Termuhlen, J.A. Ajani, and P.F. Mansfield Adenocarcinoma of the stomach in patients age 35 years and younger: no impact of early diagnosis on survival outcome J Surg Oncol 81 2002 118 124 (Pubitemid 35253621)
45. I.R. Lai, W.J. Lee, and C.N. Chen Gastric cancer in the young Hepatogastroenterology 44 1997 1641 1645
46. M. Maeta, H. Yamashiro, and A. Oka Gastric cancer in the young, with special reference to 14 pregnancy-associated cases: analysis based on 2, 325 consecutive cases of gastric cancer J Surg Oncol 58 1995 191 195
47. A. Kokkola, and P. Sipponen Gastric carcinoma in young adults Hepatogastroenterology 48 2001 1552 1555 (Pubitemid 34003473)
48. P. Guilford, B. Humar, and V. Blair Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice Gastric Cancer 13 2010 1 10
49. C.P. Theuer, T. Kurosaki, T.H. Taylor, and H. Anton-Culver Unique features of gastric carcinoma in the young: a population-based analysis Cancer 83 1998 25 33 (Pubitemid 28299625)
50. K.E. Bani-Hani Clinicopathological comparison between young and old age patients with gastric adenocarcinoma Int J Gastrointest Cancer 35 2005 43 52 (Pubitemid 40458579)
51. P. Correa, and Y.H. Shiao Phenotypic and genotypic events in gastric carcinogenesis Cancer Res 54 1994 1941s 1943s (Pubitemid 24132151)
52. H. Furukawa, T. Iwanaga, and S. Imaoka Multifocal gastric cancer in patients younger than 50 years of age Eur Surg Res 21 1989 313 318 (Pubitemid 20179621)
53. J.H. Choi, H.C. Chung, and N.C. Yoo Gastric cancer in young patients who underwent curative resection. Comparative study with older patients Am J Clin Oncol 19 1996 45 48 (Pubitemid 26037672)
54. P.J. Matley, D.M. Dent, M.V. Madden, and S.K. Price Gastric carcinoma in young adults Ann Surg 208 1988 593 596 (Pubitemid 18267700)
55. P.L. Tso, W.L. Bringaze 3rd, A.H. Dauterive, P. Correa, and I. Cohn Jr. Gastric carcinoma in the young Cancer 59 1987 1362 1365 (Pubitemid 17035485)
56. H. Medina-Franco, M.J. Heslin, and R. Cortes-Gonzalez Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study Ann Surg Oncol 7 2000 515 519 (Pubitemid 30666491)
57. R. Santoro, F. Carboni, P. Lepiane, G.M. Ettorre, and E. Santoro Clinicopathological features and prognosis of gastric cancer in young European adults Br J Surg 94 2007 737 742 (Pubitemid 46910068)
58. T. Eguchi, Y. Takahashi, M. Yamagata, M. Kasahara, and M. Fujii Gastric cancer in young patients J Am Coll Surg 188 1999 22 26 (Pubitemid 29031966)
59. K. Sugano Gastric cancer: pathogenesis, screening, and treatment Gastrointest Endosc Clin N Am 18 2008 513 522
60. C.P. Theuer, C. de Virgilio, and G. Keese Gastric adenocarcinoma in patients 40 years of age or younger Am J Surg 172 1996 473 476
61. G. Maconi, H. Kurihara, and V. Panizzo Italian Research Group for Gastric Cancer: Gastric cancer in young patients with no alarm symptoms: focus on delay in diagnosis, stage of neoplasm and survival Scand J Gastroenterol 38 2003 1249 1255 (Pubitemid 38096083)
62. J.F. Lai, S. Kim, and C. Li Clinicopathologic characteristics and prognosis for young gastric adenocarcinoma patients after curative resection Ann Surg Oncol 15 2008 1464 1469
63. A. Saito, Y. Kanai, and C. Maesawa Disruption of E-cadherin-mediated cell adhesion systems in gastric cancers in young patients Jpn J Cancer Res 90 1999 993 999 (Pubitemid 29500440)
64. Y. Zhang, X. Liu, and Y. Fan Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China Int J Cancer 119 2006 2592 2596 (Pubitemid 44691312)