HER-2/neu expression is consistent in primary and metastatic lung adenocarcinoma

Lung Cancer

Volumn 71, Issue 3, 2011, Pages 371-372

  Fassan, Matteo ^a   Rea, Federico ^a   Pizzi, Marco ^a   Rugge, Massimo ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

Adenocarcinoma; HER 2 neu; Immunohistochemistry; Lung cancer; Targeted therapy

Indexed keywords

ADULT; AGED; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LETTER; LUNG ADENOCARCINOMA; LYMPH NODE METASTASIS; MALE; ONCOGENE NEU; PRIORITY JOURNAL;

ADENOCARCINOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; RECEPTOR, ERBB-2;

EID: 79851501899     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2010.12.024     Document Type: Letter

References (5)

1. Hirsch F.R., Varella-Garcia M., Franklin W.A., et al. Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. Br J Cancer 2002, 86:1449-1456.
2. Kuyama S., Hotta K., Tabata M., et al. Impact of HER2 gene and protein status on the treatment outcome of cisplatin-based chemoradiotherapy for locally advanced non-small cell lung cancer. J Thorac Oncol 2008, 3:477-482.
3. Tan D., Deeb G., Wang J., et al. HER-2/neu protein expression and gene alteration in stage I-IIIA non-small-cell lung cancer: a study of 140 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in situ hybridization. Diagn Mol Pathol 2003, 12:201-211.
4. Sun M., Behrens C., Feng L., et al. HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res 2009, 15:4829-4837.
5. Akita K., Inagaki H., Sato S., et al. p185HER-2/neu and p21CIP1/WAF1 expression in primary tumors and lymph node metastases in non-small cell lung cancer. Jpn J Cancer Res 2002, 93:1007-1011.