Efficacy of mood stabilisers in the treatment of impulsive or repetitive aggression: Systematic review and meta-analysis

British Journal of Psychiatry

Volumn 198, Issue 2, 2011, Pages 93-98

  Jones, Roland M ^a,b   Arlidge, James ^a   Gillham, Rebecca ^a   Reagu, Shuja ^a   Van Den Bree, Marianne ^a   Taylor, Pamela J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b Llanarth Court Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; ETIRACETAM; LITHIUM; MOOD STABILIZER; OXCARBAZEPINE; PHENYTOIN; PLACEBO; VALPROATE SEMISODIUM; VALPROIC ACID;

AGGRESSIVENESS; APPETITE; ASTHENIA; BEHAVIOR DISORDER; DEPRESSION; DISEASE SEVERITY; DIZZINESS; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG WITHDRAWAL; HUMAN; IMPULSIVENESS; INTELLECTUAL IMPAIRMENT; META ANALYSIS; NAUSEA; NERVOUSNESS; ORGANIC BRAIN SYNDROME; PSYCHOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEDATION; SIDE EFFECT; SYSTEMATIC REVIEW; TREMOR;

ADULT; AGGRESSION; ANTICONVULSANTS; ANTIMANIC AGENTS; HUMANS; IMPULSE CONTROL DISORDERS; LITHIUM COMPOUNDS; MALE; PLACEBOS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECURRENCE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 79851494287     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.110.083030     Document Type: Review

References (39)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). APA, 1994.
2. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. WHO, 1992.
3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-IIII). APA, 1980.
4. Mayes R, Horwitz AV. DSM-III and the revolution in the classification of mental illness. J Hist Behav Sci 2005; 41: 249-67. (Pubitemid 41311768)
5. Ross AT, Jackson V. Dilantin sodium: its influence on conduct and on ratings of institutionalized epileptics. Ann Intern Med 1940; 14: 770-3.
6. Worrall EP, Moody JP, Naylor GJ. Lithium in non-manic-depressives: antiaggressive effect and red blood cell lithium values. Br J Psychiatry 1975; 136: 464-8.
7. Dale PG. Lithium therapy in aggressive mentally subnormal patients. Br J Psychiatry 1980; 137: 469-74. (Pubitemid 10030112)
8. Haw C, Stubbs J. A survey of the off-label use of mood stabilizers in a large psychiatric hospital. J Psychopharmacol 2005; 19: 402-7. (Pubitemid 41003137)
9. Mercer D, Douglass AB, Links PS. Meta-analyses of mood stabilizers, antidepressants and antipsychotics in the treatment of borderline personality disorder: effectiveness for depression and anger symptoms. J Pers Disord 2009; 23: 156-74.
10. Nose M, Cipriani A, Biancosino B, Grassi L, Barbui C. Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials. Int Clin Psychopharmacol 2006; 21: 345-53. (Pubitemid 44498276)
11. Huband N, Ferriter M, Nathan R, Jones H. Antiepileptics for aggression and associated impulsivity. Cochrane Database Syst Rev 2010; 2: CD003499.
12. Berkowitz L. Aggression: It's Causes, Consequences, and Control. McGraw-Hill, 1993.
13. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12.
14. Altman DG, Bland JM. Detecting skewness from summary information. BMJ 1996 313: 1200.
15. Higgins JP, White IR, Anzures-Cabrera J. Meta-analysis of skewed data: combining results reported on log-transformed or raw scales. Stat Med 2008; 27: 6072-92.
16. Maletzky BM, Klotter J. Episodic dyscontrol: a controlled replication. Dis Nerv Syst 1974; 35: 175-9.
17. Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol 1991; 17: 341-9.
18. Barratt ES, Stanford MS, Kent TA, Felthous A. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry 1997; 41: 1045-61. (Pubitemid 27225992)
19. Stanford MS, Houston RJ, Mathias CW, Greve KW, Villemarette-Pittman NR, Adams D. A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression. Psychiatry Res 2001; 10: 193-203. (Pubitemid 32817080)
20. Houston RJ, Standford MS. Characterisation of aggressive behaviour and phenytoin response. Aggress Behav 2006; 32: 38-43. (Pubitemid 43470571)
21. Stanford MS, Helfritz LE, Conklin SM, Villemarette-Pittman NR, Greve KW, Adams D, et al. A comparison of anticonvulsants in the treatment of impulsive aggression. Exp Clin Psychopharmacol 2005; 13: 72-7. (Pubitemid 40261832)
22. Sheard MH, Marini JL, Bridges CI, Wagner E. The effect of lithium on impulsive aggressive behavior in man. Am J Psychiatry 1976; 133: 1409-13.
23. Hollander E, Tracy KA, Swann AC, Coccaro EF, McElroy SL, Wozniak P, et al. Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders. Neuropsychopharmacology 2003; 28: 1186-97.
24. Mattes JA. Oxcarbazepine in patients with impulsive aggression: a double-blind, placebo-controlled trial. J Clin Psychopharmacol 2005; 25: 575-9. (Pubitemid 41669053)
25. Mattes JA. Levetiracetam in patients with impulsive aggression: a double-blind, placebo-controlled trial. J Clin Psychiatry 2008; 69: 310-5. (Pubitemid 351469275)
26. Tyrer P, Bateman AW. Drug treatment for personality disorders. Adv Psychiatr Treat 2004; 10: 389-98. (Pubitemid 39232445)
27. Gardner DL, Cowdry RW. Positive effects of carbamazepine on behavioural dyscontrol in borderline personality disorder. Am J Psychiatry 1986; 143: 519-22. (Pubitemid 16119761)
28. Cowdry RW, Gardner DL. Pharmacotherapy of borderline personality disorder: alprazolam, carbamazepine, trifluoperazine, tranylcypromine. Arch Gen Psychiatry 1988; 45: 111-9. (Pubitemid 18052841)
29. Mattes JA. Comparative effectiveness of carbamazepine and propranolol for rage outbursts. J Neuropsychiatry Clin Neurosci 1990; 2: 159-64. (Pubitemid 20168650)
30. De la Fuente JM, Lotstra F. A trial of carbamazepine in borderline personality disorder. Eur Neuropsychopharmacol 1994; 4: 479-86.
31. Nickel MK, Nickel C, Mitterlehner FO, Tritt K, Lahmann C, Leiberich PK, et al. Topiramate treatment of aggression in female borderline personality disorder patients: a double-blind, placebo-controlled study. J Clin Psychiatry 2004; 65: 1515-9.
32. Nickel C, Lahmann C, Tritt K, Muehlbacher M, Kaplan P, Kettler C, et al. Topiramate in treatment of depressive and anger symptoms in female depressive patients: a randomized, double-blind, placebo-controlled study. J Affect Disord 2005; 87: 243-52. (Pubitemid 41039946)
33. Nickel MK, Nickel C, Kaplan P, Lahmann C, Muhlbacher M, Tritt K, et al. Treatment of aggression with topiramate in male borderline patients: a double-blind, placebo-controlled study. Biol Psychiatry 2005; 57: 495-9. (Pubitemid 40311984)
34. Loew TH, Nickel MK, Muehlbacher M, Kaplan P, Nickel C, Kettler C, et al. Topiramate treatment for women with borderline personality disorder: a double-blind, placebo-controlled study. J Clin Psychopharmacol 2006; 26: 61-6. (Pubitemid 43167093)
35. Tritt K, Nickel C, Lahmann C, Leiberich PK, Rother WK, Loew TH, et al. Lamotrigine treatment of aggression in female borderline-patients: a randomized, double-blind, placebo-controlled study. J Psychopharmacol 2005; 19: 287-91. (Pubitemid 40694947)
36. Hollander E, Allen A, Lopez RP, Bienstock CA, Grossman R, Siever LJ, et al. A preliminary double-blind, placebo-controlled trial of divalproex sodium in borderline personality disorder. J Clin Psychiatry 2001; 62: 199-203. (Pubitemid 32270095)
37. Frankenburg FR, Zanarini MC. Divalproex sodium treatment of women with borderline personality disorder and bipolar II disorder: a double-blind placebo-controlled pilot study. J Clin Psychiatry 2002; 63: 442-6. (Pubitemid 34507223)
38. Marini JL, Sheard MH. Sustained-release lithium carbonate in a double-blind study: serum lithium levels, side effects and placebo response. J Clin Pharmacol 1976; 16: 276-83.
39. Links PS, Steiner M, Boiago I, Irwin D. Lithium therapy for borderline patients: preliminary findings. J Personal Disord 1990; 4: 173-81. (Pubitemid 20339898)