Cerebrovascular pathophysiology following mild traumatic brain injury

Clinical Physiology and Functional Imaging

Volumn 31, Issue 2, 2011, Pages 85-93

  Len, T K ^a   Neary, J P ^a  

^a UNIVERSITY OF REGINA   (Canada)

Author keywords

Cerebral autoregulation; Cerebral blood flow; Cerebrovascular reactivity; Concussion; Neuroautonomic regulation

Indexed keywords

AUTOREGULATION; BRAIN BLOOD FLOW; CONCUSSION; DOPPLER FLOWMETRY; HUMAN; MEAN ARTERIAL PRESSURE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; OXYGENATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TRAUMATIC BRAIN INJURY;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; BRAIN; BRAIN CONCUSSION; BRAIN INJURIES; CARDIOVASCULAR SYSTEM; CEREBROVASCULAR CIRCULATION; HOMEOSTASIS; HUMANS; OXYGEN; OXYGEN CONSUMPTION; TERMINOLOGY AS TOPIC;

EID: 79851476017     PISSN: 14750961     EISSN: 1475097X     Source Type: Journal    
DOI: 10.1111/j.1475-097X.2010.00990.x     Document Type: Review

References (77)

1. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol (2009); 296: 1473-1495.
2. Akca O. Optimizing the intraoperative management of carbon dioxide concentration. Curr Opin Anaesthesiol (2006); 19: 19-25.
3. Alexander MP. Mild traumatic brain injury: pathophysiology, natural history, and clinical management. Neurology (1995); 45: 1253-1260.
4. American Academy of Neurology. Practice parameter: the management of concussion in sports (summary statement). Report of the Quality Standards Subcommittee. Neurology (1997); 48: 581-585.
5. American College of Sports Medicine. Concussion (mild traumatic brain injury) and the team physician: a consensus statement. Med Sci Sports Exerc (2006); 38: 395-399.
6. Armstead WM, Kurth CD. Different cerebral hemodynamic responses following fluid percussion brain injury in the newborn and juvenile pig. J Neurotrauma (1994); 11: 487-497.
7. Aubry M, Cantu R, Dvorak J, Graf-Baumann T, Johnston KM, Kelly J, Lovell M, McCrory P, Meeuwisse WH, Schamasch P. Summary and agreement statement of the 1st International Symposium on Concussion in Sport, Vienna 2001. Clin J Sport Med (2002); 12: 6-11.
8. Becelewski J, Pierzchala K. Cerebrovascular reactivity in patients with mild head injury. Neurol Neurochir Pol (2003); 37: 339.
9. Bhambhani Y, Maikala R, Farag M, Rowland G. Reliability of near-infrared spectroscopy measures of cerebral oxygenation and blood volume during handgrip exercise in nondisabled and traumatic brain-injured subjects. J Rehabil Res Dev (2006); 43: 845-856.
10. Biasca N, Maxwell WL. Minor traumatic brain injury in sports: a review in order to prevent neurological sequelae. Prog Brain Res (2007); 161: 263-291.
11. Bonne O, Gilboa A, Louzoun Y, Kempf-Sherf O, Katz M, Fishman Y, Ben-Nahum Z, Krausz Y, Bocher M, Lester H, Chisin R, Lerer B. Cerebral blood flow in chronic symptomatic mild traumatic brain injury. Psychiatry Res (2003); 124: 141-152.
12. Buchner K, Meixensberger J, Dings J, Roosen K. Near-infrared spectroscopy: not useful to monitor cerebral oxygenation after severe brain injury. Zentralbl Neurochir (2000); 61: 69-73.
13. Carrera E, Lee LK, Giannopoulos S, Marshall RS. Cerebrovascular reactivity and cerebral autoregulation in normal subjects. J Neurol Sci (2009); 285: 191-194.
14. Cassidy JD, Carroll LJ, Peloso PM, Borg J, von Holst H, Holm L, Kraus J, Coronado VG. Incidence, risk factors and prevention of mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J Rehabil Med (2004); 36 (Suppl. 43): 28-60.
15. Centers for Disease Control and Prevention. Sports-related recurrent brain injuries - United States. JAMA (1997); 277: 1190-1191.
16. Centers for Disease Control and Prevention. Heads Up: Facts for Physicians About Mild Traumatic Brain Injury (2007). Centers for Disease Control and Prevention, Atlanta, GA.
17. Chan KH, Dearden NM, Miller JD. The significance of posttraumatic increase in cerebral blood flow velocity: a transcranial Doppler ultrasound study. Neurosurgery (1992); 30: 697-700.
18. Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage (2004); 22: 68-82.
19. Congress of Neurological Surgeons. Committee on head injury nomenclature: glossary of head injury. Clin Neurosurg (1966); 12: 386-394.
20. Cote C, Neary JP, Goodman D, Parkhouse W, Bhambhani YN. Cerebral oxygenation and blood volume changes during exercise following sport-induced concussion. Appl Physiol Nutr Metab (2006); 31(Suppl.): S14.
21. Czosnyka M, Smielewski P, Piechnik S, Steiner LA, Pickard JD. Cerebral autoregulation following head injury. J Neurosurg (2001); 95: 756-763.
22. Daugherty WP, Levasseur JE, Sun D, Rockswold GL, Bullock MR. Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats. J Neurosurg (2004); 101: 499-504.
23. Davis KL, Jenkins LW, DeWitt DS, Prough DS. Mild traumatic brain injury does not modify the cerebral blood flow profile of secondary forebrain ischemia in Wistar rats. J Neurotrauma (1998); 15: 615-625.
24. Davis GA, Iverson GL, Guskiewicz KM, Ptito A, Johnston KM. Contributions of neuroimaging, balance testing, electrophysiology and blood markers to the assessment of sport-related concussion. Br J Sports Med (2009); 43(Suppl.): i36-i45.
25. Defense and Veterans Brain Injury Center Working Group. Clinical practice guideline and recommendations. (2006).
26. DeWitt DS, Prough DS. Traumatic cerebral vascular injury: the effects of concussive brain injury on the cerebral vasculature. J Neurotrauma (2003); 20: 795-825.
27. DeWitt DS, Prough DS, Taylor CL, Whitley JM. Reduced cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and mild hemorrhage in cats. J Neurosurg (1992); 76: 812-821.
28. 2-reactivity after severe head injury. Acta Neurochir (Wien) (1996); 138: 425-434.
29. Edvinsson L, Krause DN. Cerebral Blood Flow and Metabolism (2002). Lippincott, Williams & Wilkins, Philadelphia.
30. Ellemberg D, Henry LC, Macciocchi SN, Guskiewicz KM, Broglio SP. Advances in sport concussion assessment: from behavioral to brain imaging measures. J Neurotrauma (2009); 26: 2365-2382.
31. 2 responses of cerebral blood flow in patients with acute severe head injury. J Neurosurg (1978); 48: 689-703.
32. Gaetz M, Goodman D, Weinberg H. Electrophysiological evidence for the cumulative effects of concussion. Brain Inj (2000); 14: 1077-1088.
33. Gall B, Parkhouse W, Goodman D. Heart rate variability of recently concussed athletes at rest and exercise. Med Sci Sports Exerc (2004a); 36: 1269-1274.
34. Gall B, Parkhouse WS, Goodman D. Exercise following a sport induced concussion. Br J Sports Med (2004b); 38: 773-777.
35. Giza CC, Hovda DA. The neurometabolic cascade of concussion. J Athl Train (2001); 36: 228-235.
36. Golding EM, Robertson CS, Bryan RM Jr. The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertens (1999a); 21: 299-332.
37. 2 and hypotension after mild cortical impact injury. Am J Physiol Heart Circ Physiol (1999b); 277: H1457-H1466.
38. Goldstein B, DeKing D, DeLong DJ, Kempski MH, Cox C, Kelly MM, Nichols DD, Woolf PD. Autonomic cardiovascular state after severe brain injury and brain death in children. Crit Care Med (1993); 21: 228-233.
39. Goldstein B, Toweill D, Lai S, Sonnenthal K, Kimberly B. Uncoupling of the autonomic and cardiovascular systems in acute brain injury. Am J Physiol (1998); 275: R1287-R1292.
40. Gommer ED, Staals J, van Oostenbrugge RJ, Lodder J, Mess WH, Reulen JP. Dynamic cerebral autoregulation and cerebrovascular reactivity: a comparative study in lacunar infarct patients. Physiol Meas (2008); 29: 1293-1303.
41. Grindel SH. Epidemiology and pathophysiology of minor traumatic brain injury. Curr Sports Med Rep (2003); 2: 18-23.
42. Guskiewicz KM, Bruce SL, Cantu RC, Ferrara MS, Kelly JP, McCrea M, Putukian M, Valovich McLeod TC. National Athletic Trainers' Association position statement: management of sport-related concussion. J Athl Train (2004); 39: 280-297.
43. Hanna-Pladdy B, Berry ZM, Bennett T, Phillips HL, Gouvier WD. Stress as a diagnostic challenge for postconcussive symptoms: sequelae of mild traumatic brain injury or physiological stress response. Clin Neuropsychol (2001); 15: 289-304.
44. Hovda DA, Lee SM, Smith ML, Von Stuck S, Bergsneider M, Kelly D, Shalmon E, Martin N, Caron M, Mazziotta J, Phelps M, Becker DP. The neurochemical and metabolic cascade following brain injury: moving from animal models to man. J Neurotrauma (1995); 12: 903-906.
45. 2 in the hypocapnic-hypercapnic range in humans. J Appl Physiol (2003); 95: 129-137.
46. Jaffee MS, Helmick KM, Girard PD, Meyer KS, Dinegar K, George K. Acute clinical care and care coordination for traumatic brain injury within Department of Defense. J Rehabil Res Dev (2009); 46: 655-666.
47. Jantzen KJ, Anderson B, Steinberg FL, Kelso JA. A prospective functional MR imaging study of mild traumatic brain injury in college football players. AJNR Am J Neuroradiol (2004); 25: 738-745.
48. Johnston KM, McCrory P, Mohtadi NG, Meeuwisse W. Evidence-Based review of sport-related concussion: clinical science. Clin J Sport Med (2001); 11: 150-159.
49. Junger EC, Newell DW, Grant GA, Avellino AM, Ghatan S, Douville CM, Lam AM, Aaslid R, Winn HR. Cerebral autoregulation following minor head injury. J Neurosurg (1997); 86: 425-432.
50. Kay T, Harrington DE, Adams R, Berrol S, Cicerone K, Dahlberg C, Gerber D, Goka R, Harley P, Hilt J, Horn L, Lehmkul D, Malec J. Definition of mild traumatic brain injury. J Head Trauma Rehabil (1993); 8: 86-87.
51. Kleinschmidt A, Obrig H, Requardt M, Merboldt KD, Dirnagl U, Villringer A, Frahm J. Simultaneous recording of cerebral blood oxygenation changes during human brain activation by magnetic resonance imaging and near-infrared spectroscopy. J Cereb Blood Flow Metab (1996); 16: 817-826.
52. Kutner K, Barth J. Sports related head injury. The NAN Bulletin (1998); 14: 19-23.
53. Lang EW, Czosnyka M, Mehdorn HM. Tissue oxygen reactivity and cerebral autoregulation after severe traumatic brain injury. Crit Care Med (2003a); 31: 267-271.
54. Lang EW, Lagopoulos J, Griffith J, Yip K, Yam A, Mudaliar Y, Mehdorn HM, Dorsch NW. Cerebral vasomotor reactivity testing in head injury: the link between pressure and flow. J Neurol Neurosurg Psychiatry (2003b); 74: 1053-1059.
55. Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil (2006); 21: 375-378.
56. Leddy JJ, Kozlowski K, Fung M, Pendergast DR, Willer B. Regulatory and autoregulatory physiological dysfunction as a primary characteristic of post concussion syndrome: implications for treatment. NeuroRehabilitation (2007); 22: 199-205.
57. Len TK, Neary JP, Goodman DG, Asmundson GJG. Effect of mild traumatic brain injury on cerebrovascular response. Br J Sports Med (2009); 43(Suppl.): i103-i104.
58. Lewelt W, Jenkins LW, Miller JD. Autoregulation of cerebral blood flow after experimental fluid percussion injury of the brain. J Neurosurg (1980); 53: 500-511.
59. Lovell MR, Pardini JE, Welling J, Collins MW, Bakal J, Lazar N, Roush R, Eddy WF, Becker JT. Functional brain abnormalities are related to clinical recovery and time to return-to-play in athletes. Neurosurgery (2007); 61: 352-360.
60. Mandera M, Larysz D, Wojtacha M. Changes in cerebral hemodynamics assessed by transcranial Doppler ultrasonography in children after head injury. Childs Nerv Syst (2002); 18: 124-128.
61. McCrory P, Johnston K, Meeuwisse W, Aubry M, Cantu R, Dvorak J, Graf-Baumann T, Kelly J, Lovell M, Schamasch P. Summary and agreement statement of the 2nd International Conference on Concussion in Sport, Prague 2004. Br J Sports Med (2005); 39: 196-204.
62. rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med (2009); 19: 185-200.
63. McQuire JC, Sutcliffe JC, Coats TJ. Early changes in middle cerebral artery blood flow velocity after head injury. J Neurosurg (1998); 89: 526-532.
64. Mihalik JP, Stump JE, Collins MW, Lovell MR, Field M, Maroon JC. Posttraumatic migraine characteristics in athletes following sports-related concussion. J Neurosurg (2005); 102: 850-855.
65. Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA. Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J Neurosurg (1984); 61: 241-253.
66. Panerai RB, Simpson DM, Deverson ST, Mahony P, Hayes P, Evans DH. Multivariate dynamic analysis of cerebral blood flow regulation in humans. IEEE Trans Biomed Eng (2000); 47: 419-423.
67. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev (1990); 2: 161-192.
68. Rangel-Castilla L, Gasco J, Nauta HJ, Okonkwo DO, Robertson CS. Cerebral pressure autoregulation in traumatic brain injury. Neurosurg Focus (2008); 25: E7.
69. Singhal S, Markus HS. Cerebrovascular reactivity and dynamic autoregulation in nondemented patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). J Neurol (2005); 252: 163-167.
70. Strebel S, Lam AM, Matta BF, Newell DW. Impaired cerebral autoregulation after mild brain injury. Surg Neurol (1997); 47: 128-131.
71. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation (1996); 93: 1043-1065.
72. Thompson J, Sebastianelli W, Slobounov S. EEG and postural correlates of mild traumatic brain injury in athletes. Neurosci Lett (2005); 377: 158-163.
73. Vavilala MS, Muangman S, Tontisirin N, Fisk D, Roscigno C, Mitchell P, Kirkness C, Zimmerman JJ, Chesnut R, Lam AM. Impaired cerebral autoregulation and 6-month outcome in children with severe traumatic brain injury: preliminary findings. Dev Neurosci (2006); 28: 348-353.
74. Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth (2007); 99: 4-9.
75. Wilberger J, Ortega J, Slobounov S. Concussion mechanisms and pathophysiology. In: Foundations of Sport-Related Brain Injuries (eds Slobounov, S, Sebastianelli, W) (2006), pp. 45-64. Springer, New York.
76. Wright JK, Zant E, Groom K, Schlegel RE, Gilliland K. Case report: treatment of mild traumatic brain injury with hyperbaric oxygen. Undersea Hyperb Med (2009); 36: 391-399.
77. Zhang R, Zuckerman JH, Iwasaki K, Wilson TE, Crandall CG, Levine BD. Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation (2002); 106: 1814-1820.