-
1
-
-
75149188853
-
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs
-
10.1158/0008-5472.CAN-09-2676, 2802734, 20028868
-
Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res 2010, 70:12-13. 10.1158/0008-5472.CAN-09-2676, 2802734, 20028868.
-
(2010)
Cancer Res
, vol.70
, pp. 12-13
-
-
Wolkenhauer, O.1
Auffray, C.2
Baltrusch, S.3
Blüthgen, N.4
Byrne, H.5
Cascante, M.6
Ciliberto, A.7
Dale, T.8
Drasdo, D.9
Fell, D.10
Ferrell, J.E.11
Gallahan, D.12
Gatenby, R.13
Günther, U.14
Harms, B.D.15
Herzel, H.16
Junghanss, C.17
Kunz, M.18
van Leeuwen, I.19
Lenormand, P.20
Levi, F.21
Linnebacher, M.22
Lowengrub, J.23
Maini, P.K.24
Malik, A.25
Rateitschak, K.26
Sansom, O.27
Schäfer, R.28
Schürrle, K.29
Sers, C.30
Schnell, S.31
Shibata, D.32
Tyson, J.33
Vera, J.34
White, M.35
Zhivotovsky, B.36
Jaster, R.37
more..
-
2
-
-
33750125308
-
Pancreatic cancer: a review of recent advances
-
10.1517/13543784.15.11.1395, 17040199
-
Eckel F, Schneider G, Schmid RM. Pancreatic cancer: a review of recent advances. Expert Opin Investig Drugs 2006, 15:1395-1410. 10.1517/13543784.15.11.1395, 17040199.
-
(2006)
Expert Opin Investig Drugs
, vol.15
, pp. 1395-1410
-
-
Eckel, F.1
Schneider, G.2
Schmid, R.M.3
-
3
-
-
18844431062
-
Pancreatic cancer: basic and clinical aspects
-
10.1053/j.gastro.2005.04.001, 15887154
-
Schneider G, Siveke JT, Eckel F, Schmid RM. Pancreatic cancer: basic and clinical aspects. Gastroenterology 2005, 128:1606-1625. 10.1053/j.gastro.2005.04.001, 15887154.
-
(2005)
Gastroenterology
, vol.128
, pp. 1606-1625
-
-
Schneider, G.1
Siveke, J.T.2
Eckel, F.3
Schmid, R.M.4
-
4
-
-
4644317795
-
Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
-
10.1097/00006676-200410000-00002, 15367883
-
Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, Keogh G, Merrett N, Pirola R, Wilson JS. Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 2004, 29:179-187. 10.1097/00006676-200410000-00002, 15367883.
-
(2004)
Pancreas
, vol.29
, pp. 179-187
-
-
Apte, M.V.1
Park, S.2
Phillips, P.A.3
Santucci, N.4
Goldstein, D.5
Kumar, R.K.6
Ramm, G.A.7
Buchler, M.8
Friess, H.9
McCarroll, J.A.10
Keogh, G.11
Merrett, N.12
Pirola, R.13
Wilson, J.S.14
-
5
-
-
38149070150
-
Crucial role of fibrogenesis in pancreatic diseases
-
10.1016/j.bpg.2007.10.004, 18206810
-
Jaster R, Emmrich J. Crucial role of fibrogenesis in pancreatic diseases. Best Pract Res Clin Gastroenterol 2008, 22:17-29. 10.1016/j.bpg.2007.10.004, 18206810.
-
(2008)
Best Pract Res Clin Gastroenterol
, vol.22
, pp. 17-29
-
-
Jaster, R.1
Emmrich, J.2
-
6
-
-
17144404527
-
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
-
10.1053/j.gastro.2004.12.036, 15825074
-
Bachem MG, Schunemann M, Ramadani M, Siech M, Beger H, Buck A, Zhou S, Schmid-Kotsas A, Adler G. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 2005, 128:907-921. 10.1053/j.gastro.2004.12.036, 15825074.
-
(2005)
Gastroenterology
, vol.128
, pp. 907-921
-
-
Bachem, M.G.1
Schunemann, M.2
Ramadani, M.3
Siech, M.4
Beger, H.5
Buck, A.6
Zhou, S.7
Schmid-Kotsas, A.8
Adler, G.9
-
7
-
-
10744221950
-
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta
-
Müerköster S, Wegehenkel K, Arlt A, Witt M, Sipos B, Kruse ML, Sebens T, Klöppel G, Kalthoff H, Fölsch UR, Schäfer H. Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. Cancer Res 2004, 64:1331-1337.
-
(2004)
Cancer Res
, vol.64
, pp. 1331-1337
-
-
Müerköster, S.1
Wegehenkel, K.2
Arlt, A.3
Witt, M.4
Sipos, B.5
Kruse, M.L.6
Sebens, T.7
Klöppel, G.8
Kalthoff, H.9
Fölsch, U.R.10
Schäfer, H.11
-
8
-
-
0346157370
-
Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins
-
10.1097/00006676-200401000-00006, 14707728
-
Miyamoto H, Murakami T, Tsuchida K, Sugino H, Miyake H, Tashiro S. Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas 2004, 28:38-44. 10.1097/00006676-200401000-00006, 14707728.
-
(2004)
Pancreas
, vol.28
, pp. 38-44
-
-
Miyamoto, H.1
Murakami, T.2
Tsuchida, K.3
Sugino, H.4
Miyake, H.5
Tashiro, S.6
-
9
-
-
33645046890
-
Inhibitory effects of interferons on pancreatic stellate cell activation
-
Baumert JT, Sparmann G, Emmrich J, Liebe S, Jaster R. Inhibitory effects of interferons on pancreatic stellate cell activation. World J Gastroenterol 2006, 12:896-901.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 896-901
-
-
Baumert, J.T.1
Sparmann, G.2
Emmrich, J.3
Liebe, S.4
Jaster, R.5
-
10
-
-
70349992872
-
Mathematical modelling of interferon-γ signalling in pancreatic stellate cells reflects and predicts dynamics of STAT1 pathway activity
-
10.1016/j.cellsig.2009.09.019, 19781632
-
Rateitschak K, Karger A, Fitzner B, Lange F, Wolkenhauer O, Jaster R. Mathematical modelling of interferon-γ signalling in pancreatic stellate cells reflects and predicts dynamics of STAT1 pathway activity. Cell Signal 2010, 22:97-105. 10.1016/j.cellsig.2009.09.019, 19781632.
-
(2010)
Cell Signal
, vol.22
, pp. 97-105
-
-
Rateitschak, K.1
Karger, A.2
Fitzner, B.3
Lange, F.4
Wolkenhauer, O.5
Jaster, R.6
-
11
-
-
0031657551
-
How cells respond to interferons
-
10.1146/annurev.biochem.67.1.227, 9759489
-
Stark GR, Kerr IM, Williams BRG, Silverman RH, Schreiber RD. How cells respond to interferons. Annu Rev Biochem 1998, 67:227-264. 10.1146/annurev.biochem.67.1.227, 9759489.
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 227-264
-
-
Stark, G.R.1
Kerr, I.M.2
Williams, B.R.G.3
Silverman, R.H.4
Schreiber, R.D.5
-
12
-
-
0034656872
-
Interferon-based adjuvant chemoradiation therapy improves survival after pancreaticoduodenectomy for pancreatic adenocarcinoma
-
10.1016/S0002-9610(00)00369-X, 10930481
-
Nukui Y, Picozzi VJ, Traverso LW. Interferon-based adjuvant chemoradiation therapy improves survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am J Surg 2000, 179:367-371. 10.1016/S0002-9610(00)00369-X, 10930481.
-
(2000)
Am J Surg
, vol.179
, pp. 367-371
-
-
Nukui, Y.1
Picozzi, V.J.2
Traverso, L.W.3
-
13
-
-
0037406666
-
Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma
-
10.1016/S0002-9610(03)00051-5, 12727570
-
Picozzi VJ, Kozarek RA, Traverso LW. Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am J Surg 2003, 185:476-480. 10.1016/S0002-9610(03)00051-5, 12727570.
-
(2003)
Am J Surg
, vol.185
, pp. 476-480
-
-
Picozzi, V.J.1
Kozarek, R.A.2
Traverso, L.W.3
-
14
-
-
59449106165
-
Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cells
-
10.1007/s10620-008-0366-z, 18612819
-
Fitzner B, Brock P, Holzhüter SA, Nizze H, Sparmann G, Emmrich J, Liebe S, Jaster R. Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cells. Dig Dis Sci 2009, 54:309-320. 10.1007/s10620-008-0366-z, 18612819.
-
(2009)
Dig Dis Sci
, vol.54
, pp. 309-320
-
-
Fitzner, B.1
Brock, P.2
Holzhüter, S.A.3
Nizze, H.4
Sparmann, G.5
Emmrich, J.6
Liebe, S.7
Jaster, R.8
-
15
-
-
37349108815
-
Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis
-
10.1053/j.gastro.2007.09.034, 2923436, 18166357
-
Jeong WI, Park O, Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 2008, 134:248-258. 10.1053/j.gastro.2007.09.034, 2923436, 18166357.
-
(2008)
Gastroenterology
, vol.134
, pp. 248-258
-
-
Jeong, W.I.1
Park, O.2
Gao, B.3
-
16
-
-
33749339608
-
Interferon-gamma 1b for the treatment of idiopathic pulmonary fibrosis
-
10.1517/14712598.6.10.1051, 16989587
-
Bouros D, Antoniou KM, Tzouvelekis A, Siafakas NM. Interferon-gamma 1b for the treatment of idiopathic pulmonary fibrosis. Expert Opin Biol Ther 2006, 6:1051-1060. 10.1517/14712598.6.10.1051, 16989587.
-
(2006)
Expert Opin Biol Ther
, vol.6
, pp. 1051-1060
-
-
Bouros, D.1
Antoniou, K.M.2
Tzouvelekis, A.3
Siafakas, N.M.4
-
17
-
-
13344282731
-
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
-
10.1016/S0092-8674(00)81288-X, 8608597
-
Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996, 84:431-442. 10.1016/S0092-8674(00)81288-X, 8608597.
-
(1996)
Cell
, vol.84
, pp. 431-442
-
-
Meraz, M.A.1
White, J.M.2
Sheehan, K.C.3
Bach, E.A.4
Rodig, S.J.5
Dighe, A.S.6
Kaplan, D.H.7
Riley, J.K.8
Greenlund, A.C.9
Campbell, D.10
Carver-Moore, K.11
DuBois, R.N.12
Clark, R.13
Aguet, M.14
Schreiber, R.D.15
-
18
-
-
0030024563
-
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
-
10.1016/S0092-8674(00)81289-1, 8608598
-
Durbin JE, Hackenmiller R, Simon MC, Levy DE. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996, 84:443-450. 10.1016/S0092-8674(00)81289-1, 8608598.
-
(1996)
Cell
, vol.84
, pp. 443-450
-
-
Durbin, J.E.1
Hackenmiller, R.2
Simon, M.C.3
Levy, D.E.4
-
19
-
-
33847176982
-
Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression
-
10.1016/j.cellsig.2006.10.002, 17116388
-
Fitzner B, Brock P, Nechutova H, Glass A, Karopka T, Koczan D, Thiesen HJ, Sparmann G, Emmrich J, Liebe S, Jaster R. Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression. Cell Signal 2007, 19:782-790. 10.1016/j.cellsig.2006.10.002, 17116388.
-
(2007)
Cell Signal
, vol.19
, pp. 782-790
-
-
Fitzner, B.1
Brock, P.2
Nechutova, H.3
Glass, A.4
Karopka, T.5
Koczan, D.6
Thiesen, H.J.7
Sparmann, G.8
Emmrich, J.9
Liebe, S.10
Jaster, R.11
-
20
-
-
42049097658
-
Pancreatic stellate cells: partners in crime with pancreatic cancer cells
-
10.1158/0008-5472.CAN-07-2477, 18381413
-
Vonlaufen A, Joshi S, Qu C, Phillips PA, Xu Z, Parker NR, Toi CS, Pirola RC, Wilson JS, Goldstein D, Apte MV. Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res 2008, 68:2085-2093. 10.1158/0008-5472.CAN-07-2477, 18381413.
-
(2008)
Cancer Res
, vol.68
, pp. 2085-2093
-
-
Vonlaufen, A.1
Joshi, S.2
Qu, C.3
Phillips, P.A.4
Xu, Z.5
Parker, N.R.6
Toi, C.S.7
Pirola, R.C.8
Wilson, J.S.9
Goldstein, D.10
Apte, M.V.11
-
21
-
-
38849141696
-
Cancer-associated stromal fibroblasts promote pancreatic tumor progression
-
10.1158/0008-5472.CAN-07-5714, 2519173, 18245495
-
Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB, Logsdon CD. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res 2008, 68:918-926. 10.1158/0008-5472.CAN-07-5714, 2519173, 18245495.
-
(2008)
Cancer Res
, vol.68
, pp. 918-926
-
-
Hwang, R.F.1
Moore, T.2
Arumugam, T.3
Ramachandran, V.4
Amos, K.D.5
Rivera, A.6
Ji, B.7
Evans, D.B.8
Logsdon, C.D.9
-
22
-
-
0021330445
-
Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice
-
Corbett TH, Roberts BJ, Leopold WR, Peckham JC, Wilkoff LJ, Griswold DP, Schabel FM. Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. Cancer Res 1984, 4:717-726.
-
(1984)
Cancer Res
, vol.4
, pp. 717-726
-
-
Corbett, T.H.1
Roberts, B.J.2
Leopold, W.R.3
Peckham, J.C.4
Wilkoff, L.J.5
Griswold, D.P.6
Schabel, F.M.7
-
23
-
-
0036785330
-
Extracellular signal-regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells
-
10.1136/gut.51.4.579, 1773393, 12235084
-
Jaster R, Sparmann G, Emmrich J, Liebe S. Extracellular signal-regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut 2002, 51:579-584. 10.1136/gut.51.4.579, 1773393, 12235084.
-
(2002)
Gut
, vol.51
, pp. 579-584
-
-
Jaster, R.1
Sparmann, G.2
Emmrich, J.3
Liebe, S.4
-
24
-
-
6344284114
-
Bacteriolytic therapy can generate a potent immune response against experimental tumors
-
10.1073/pnas.0406242101, 523456, 15471990
-
Agrawal N, Bettegowda C, Cheong I, Geschwind JF, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz LA, Pomper M, Abusedera M, Wahl RL, Kinzler KW, Zhou S, Huso DL, Vogelstein B. Bacteriolytic therapy can generate a potent immune response against experimental tumors. Proc Natl Acad Sci USA 2004, 101:15172-15177. 10.1073/pnas.0406242101, 523456, 15471990.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15172-15177
-
-
Agrawal, N.1
Bettegowda, C.2
Cheong, I.3
Geschwind, J.F.4
Drake, C.G.5
Hipkiss, E.L.6
Tatsumi, M.7
Dang, L.H.8
Diaz, L.A.9
Pomper, M.10
Abusedera, M.11
Wahl, R.L.12
Kinzler, K.W.13
Zhou, S.14
Huso, D.L.15
Vogelstein, B.16
-
25
-
-
0036731485
-
Stats: transcriptional control and biological impact
-
10.1038/nrm909, 12209125
-
Levy DE, Darnell JE. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 2002, 3:651-662. 10.1038/nrm909, 12209125.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 651-662
-
-
Levy, D.E.1
Darnell, J.E.2
-
27
-
-
0034641751
-
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain
-
10.1073/pnas.190318397, 27039, 10973496
-
Begitt A, Meyer T, van Rossum M, Vinkemeier U. Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc Natl Acad Sci USA 2000, 97:10418-10423. 10.1073/pnas.190318397, 27039, 10973496.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10418-10423
-
-
Begitt, A.1
Meyer, T.2
van Rossum, M.3
Vinkemeier, U.4
-
28
-
-
33744963148
-
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
-
10.1074/jbc.M509595200, 16473883
-
Wormald S, Zhang JG, Krebs DL, Mielke LA, Silver J, Alexander WS, Speed TP, Nicola NA, Hilton DJ. The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J Biol Chem 2006, 281:11135-11143. 10.1074/jbc.M509595200, 16473883.
-
(2006)
J Biol Chem
, vol.281
, pp. 11135-11143
-
-
Wormald, S.1
Zhang, J.G.2
Krebs, D.L.3
Mielke, L.A.4
Silver, J.5
Alexander, W.S.6
Speed, T.P.7
Nicola, N.A.8
Hilton, D.J.9
-
29
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
10.1038/43213, 9202126
-
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 1997, 387:921-924. 10.1038/43213, 9202126.
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
Masuhara, M.2
Yokouchi, M.3
Suzuki, R.4
Sakamoto, H.5
Mitsui, K.6
Matsumoto, A.7
Tanimura, S.8
Ohtsubo, M.9
Misawa, H.10
Miyazaki, T.11
Leonor, N.12
Taniguchi, T.13
Fujita, T.14
Kanakura, Y.15
Komiya, S.16
Yoshimura, A.17
-
31
-
-
51749122228
-
Dynamical Modeling and multi-experiment fitting with PottersWheel
-
10.1093/bioinformatics/btn350, 2530888, 18614583
-
Maiwald T, Timmer J. Dynamical Modeling and multi-experiment fitting with PottersWheel. Bioinformatics 2008, 24:2037-2043. 10.1093/bioinformatics/btn350, 2530888, 18614583.
-
(2008)
Bioinformatics
, vol.24
, pp. 2037-2043
-
-
Maiwald, T.1
Timmer, J.2
-
32
-
-
41849116690
-
Roles of unphosphorylated STATs in signalling
-
10.1038/cr.2008.41, 18364677
-
Yang J, Stark GR. Roles of unphosphorylated STATs in signalling. Cell Res 2008, 18:443-451. 10.1038/cr.2008.41, 18364677.
-
(2008)
Cell Res
, vol.18
, pp. 443-451
-
-
Yang, J.1
Stark, G.R.2
-
33
-
-
29144434998
-
Computational processing and error reduction strategies for standardized quantitative data in biological networks
-
10.1111/j.1742-4658.2005.05037.x, 16336276
-
Schilling M, Maiwald T, Bohl S, Kollmann M, Kreutz C, Timmer J, Klingmüller U. Computational processing and error reduction strategies for standardized quantitative data in biological networks. FEBS J 2005, 272:6400-6411. 10.1111/j.1742-4658.2005.05037.x, 16336276.
-
(2005)
FEBS J
, vol.272
, pp. 6400-6411
-
-
Schilling, M.1
Maiwald, T.2
Bohl, S.3
Kollmann, M.4
Kreutz, C.5
Timmer, J.6
Klingmüller, U.7
|