메뉴 건너뛰기




Volumn 3, Issue , 2010, Pages 81-89

Tocilizumab: A review of its safety and efficacy in rheumatoid arthritis

Author keywords

Clinical trials; Interleukin 6; Rheumatoid; Therapy

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; METHOTREXATE; PLACEBO; TOCILIZUMAB; TUMOR NECROSIS FACTOR INHIBITOR;

EID: 79751520384     PISSN: 11795441     EISSN: 11795441     Source Type: Journal    
DOI: 10.4137/CMAMD.S4864     Document Type: Review
Times cited : (87)

References (25)
  • 1
    • 0037244694 scopus 로고    scopus 로고
    • The effect of treatment on radiological progression in rheumatoid arthritis: A systematic review of randomized placebo- controlled trials
    • Jones G, Halbert J, Crotty M, et al. The effect of treatment on radiological progression in rheumatoid arthritis: a systematic review of randomized placebo- controlled trials. Rheumatology (Oxford). 2003;42:6-13.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 6-13
    • Jones, G.1    Halbert, J.2    Crotty, M.3
  • 2
    • 43249100959 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseases
    • Ding C, Jones G. Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseases. Rev Recent Clin Trials. 2006;1:193-200.
    • (2006) Rev Recent Clin Trials , vol.1 , pp. 193-200
    • Ding, C.1    Jones, G.2
  • 3
    • 69549154893 scopus 로고    scopus 로고
    • Efficacy and safety of tocilizumab, an anti- IL-6 receptor monoclonal antibody; in patients with polyarticular or oligoarticular onset juvenile idiopathic arthritis
    • Imagawa T, Mori M, Takei S, et al. Efficacy and safety of tocilizumab, an anti- IL-6 receptor monoclonal antibody; in patients with polyarticular or oligoarticular onset juvenile idiopathic arthritis. Arthritis Rheum. 2006;54:S168.
    • (2006) Arthritis Rheum. , vol.54
    • Imagawa, T.1    Mori, M.2    Takei, S.3
  • 4
    • 23644442893 scopus 로고    scopus 로고
    • Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family
    • Mihara M, Kasutani K, Okazaki M, et al. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family. Int Immunopharmacol. 2005;5:1731-40.
    • (2005) Int Immunopharmacol. , vol.5 , pp. 1731-1740
    • Mihara, M.1    Kasutani, K.2    Okazaki, M.3
  • 5
    • 36048991069 scopus 로고    scopus 로고
    • Recent advances in immunopathophysiology of interleukin-6: An innovative therapeutic drug, tocilizumab (recombinant humanized anti- human interleukin-6 receptor antibody), unveils the mysterious etiology of immunemediated inflammatory diseases
    • Ohsugi Y. Recent advances in immunopathophysiology of interleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti- human interleukin-6 receptor antibody), unveils the mysterious etiology of immunemediated inflammatory diseases. Biol Pharm Bull. 2007;30:2001-6.
    • (2007) Biol Pharm Bull. , vol.30 , pp. 2001-2006
    • Ohsugi, Y.1
  • 6
    • 33748117796 scopus 로고    scopus 로고
    • Interleukin-6: Discovery of a pleiotropic cytokine
    • Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther. 2006;8:S2.
    • (2006) Arthritis Res Ther. , vol.8
    • Kishimoto, T.1
  • 7
    • 0038166958 scopus 로고    scopus 로고
    • Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti- interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study
    • Nishimoto N, Yoshizaki K, Maeda K, et al. Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti- interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. J Rheumatol. 2003;30:1426-35.
    • (2003) J Rheumatol. , vol.30 , pp. 1426-1435
    • Nishimoto, N.1    Yoshizaki, K.2    Maeda, K.3
  • 8
    • 60149105639 scopus 로고    scopus 로고
    • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
    • Nishimoto N, Miyasaka N, Yamamoto K, et al. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol. 2009;19:12-9.
    • (2009) Mod Rheumatol. , vol.19 , pp. 12-19
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3
  • 9
    • 34447300492 scopus 로고    scopus 로고
    • Study of Active Controlled Monotherapy Used for Rheumatoid Arthritis, an IL-6 inhibitor (SAMURAI):-Evidence of clinical and radiographic benefit from an X-Ray Reader-Blinded Randomized Controlled Trial of TCZ
    • Nishimoto N, Hashimoto J, Miyasaka N, et al. Study of Active Controlled Monotherapy Used for Rheumatoid Arthritis, an IL-6 inhibitor (SAMURAI):-Evidence of clinical and radiographic benefit from an X-Ray Reader-Blinded Randomized Controlled Trial of TCZ. Ann Rheum Dis. 2007;66:1162-7.
    • (2007) Ann Rheum Dis. , vol.66 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3
  • 10
    • 33749363027 scopus 로고    scopus 로고
    • Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini RN, Taylor PC, Szechinski J, et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 2006;54:2817-29.
    • (2006) Arthritis Rheum. , vol.54 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3
  • 11
    • 70349402169 scopus 로고    scopus 로고
    • Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and efficacy in a 5-year extension study
    • Nishimoto N, Miyasaka N, Yamamoto K, et al. Long-term safety and efficacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis. 2009;68:1580-4.
    • (2009) Ann Rheum Dis. , vol.68 , pp. 1580-1584
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3
  • 12
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with TCZ in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, et al. Effect of interleukin-6 receptor inhibition with TCZ in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet. 2008;371:987-97.
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 13
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with TCZ reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The TCZ in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL, et al. Interleukin-6 receptor inhibition with TCZ reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The TCZ in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58:2968-80.
    • (2008) Arthritis Rheum. , vol.58 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 14
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 Receptor inhibition with TCZ improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: Results from a 24-week multicentre Randomised Placebo Controlled Trial
    • Emery P, Keystone E, Tony HP, et al. IL-6 Receptor inhibition with TCZ improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: results from a 24-week multicentre Randomised Placebo Controlled Trial. Ann Rheum Dis. 2008;67:1516-22.
    • (2008) Ann Rheum Dis. , vol.67 , pp. 1516-1522
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 15
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of TCZ monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
    • Jones G, Sebba A, Gu J, et al. Comparison of TCZ monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study. Ann Rheum Dis. 2010;69:88-96.
    • (2010) Ann Rheum Dis. , vol.69 , pp. 88-96
    • Jones, G.1    Sebba, A.2    Gu, J.3
  • 16
    • 64049115766 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with an inadequate response to methotrexate: The LITHE study
    • Kremer JM, Fleischmann RM, Halland AM, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with an inadequate response to methotrexate: the LITHE study. Arthritis Rheum. 2008;58:S4031.
    • (2008) Arthritis Rheum. , vol.58
    • Kremer, J.M.1    Fleischmann, R.M.2    Halland, A.M.3
  • 17
    • 77949481509 scopus 로고    scopus 로고
    • The AMBITION trial: Tocilizumab monotherapy for rheumatoid arthritis
    • Jones G. The AMBITION trial: Tocilizumab monotherapy for rheumatoid arthritis. Exp Rev Clin Immunol. 2010;6:189-95.
    • (2010) Exp Rev Clin Immunol. , vol.6 , pp. 189-195
    • Jones, G.1
  • 18
    • 74849102659 scopus 로고    scopus 로고
    • Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: Results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone
    • Garnero P, Thompson E, Woodworth T, Smolen JS. Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone. Arthritis Rheum. 2010;62:33-43.
    • (2010) Arthritis Rheum. , vol.62 , pp. 33-43
    • Garnero, P.1    Thompson, E.2    Woodworth, T.3    Smolen, J.S.4
  • 19
    • 62549116770 scopus 로고    scopus 로고
    • Safety of tocilizumab in patients with rheumatoid arthritis: Pooled analysis of five phase 3 clinical trials
    • Smolen JS, Beaulieu AD, Dikranian A, et al. Safety of tocilizumab in patients with rheumatoid arthritis: pooled analysis of five phase 3 clinical trials. Arthritis Rheum. 2008;58:S784.
    • (2008) Arthritis Rheum. , vol.58
    • Smolen, J.S.1    Beaulieu, A.D.2    Dikranian, A.3
  • 20
    • 70349341720 scopus 로고    scopus 로고
    • Relationship between patient characteristics and the development of serious infections in patients receiving tocilizumab: Results from long-term extension studies with a follow- up duration of 1.5 years
    • Kremer JM, van Vollenhoven RF, Ridley DJ, et al. Relationship between patient characteristics and the development of serious infections in patients receiving tocilizumab: results from long-term extension studies with a follow- up duration of 1.5 years. Arthritis Rheum. 2008;58:S783-4.
    • (2008) Arthritis Rheum. , vol.58
    • Kremer, J.M.1    van Vollenhoven, R.F.2    Ridley, D.J.3
  • 21
    • 62549116770 scopus 로고    scopus 로고
    • Hepatic aminotransferases and bilirubin levels during tocilizumab treatment of patients with rheumatoid arthritis: Pooled analysis of five phase 3 clinical trials
    • Kremer JM, Joh AK, Malamet R, Keystone EC. Hepatic aminotransferases and bilirubin levels during tocilizumab treatment of patients with rheumatoid arthritis: pooled analysis of five phase 3 clinical trials. Arthritis Rheum. 2008;58:S783.
    • (2008) Arthritis Rheum. , vol.58
    • Kremer, J.M.1    Joh, A.K.2    Malamet, R.3    Keystone, E.C.4
  • 22
    • 75749151357 scopus 로고    scopus 로고
    • Lipid and inflammatory biomarker profiles in patients receiving tocilizumab for rheumatoid arthritis: Analysis of five phase 3 clinical trials
    • Genovese MC, Smolen JS, Emery P, et al. Lipid and inflammatory biomarker profiles in patients receiving tocilizumab for rheumatoid arthritis: analysis of five phase 3 clinical trials. Arthritis Rheum. 2008;58:S531.
    • (2008) Arthritis Rheum. , vol.58
    • Genovese, M.C.1    Smolen, J.S.2    Emery, P.3
  • 23
    • 75749127901 scopus 로고    scopus 로고
    • Concomitant use of statins in tocilizumab-treated patients with rheumatoid arthritis with elevated low density lipoprotein cholesterol: Analysis of five phase 3 clinical trials
    • Genovese MC, Smolen JS, Emery P, et al. Concomitant use of statins in tocilizumab-treated patients with rheumatoid arthritis with elevated low density lipoprotein cholesterol: analysis of five phase 3 clinical trials. Arthritis Rheum. 2008;58:S785.
    • (2008) Arthritis Rheum. , vol.58
    • Genovese, M.C.1    Smolen, J.S.2    Emery, P.3
  • 24
    • 64949111191 scopus 로고    scopus 로고
    • Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: A challenge to conventional cardiovascular risk actions
    • Choy E, Sattar N. Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions. Ann Rheum Dis. 2009;68:460-9.
    • (2009) Ann Rheum Dis. , vol.68 , pp. 460-469
    • Choy, E.1    Sattar, N.2
  • 25
    • 62549116770 scopus 로고    scopus 로고
    • Low immunogenic potential of tocilizumab in patients with rheumatoid arthritis: Analysis of four phase 3 clinical trials
    • Ramos-Remus C, Genovese MC, Harre RA, et al. Low immunogenic potential of tocilizumab in patients with rheumatoid arthritis: analysis of four phase 3 clinical trials. Arthritis Rheum. 2008;58:S534.
    • (2008) Arthritis Rheum. , vol.58
    • Ramos-Remus, C.1    Genovese, M.C.2    Harre, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.