Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia

Journal of Infectious Diseases

Volumn 203, Issue 3, 2011, Pages 430-435

  Schmidt, Stanislaw ^a   Tramsen, Lars ^a   Hanisch, Mitra ^a   Latgé, Jean Paul ^b   Huenecke, Sabine ^a   Koehl, Ulrike ^a   Lehrnbecher, Thomas ^a  

^a GOETHE UNIVERSITY   (Germany)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; PERFORIN; RANTES;

ADAPTIVE IMMUNITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CELL ACTIVITY; CONIDIUM; FUNGAL SPORE GERMINATION; FUNGUS HYPHAE; HUMAN; IN VITRO STUDY; INVASIVE ASPERGILLOSIS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ASPERGILLUS FUMIGATUS; CELLS, CULTURED; CHEMOKINE CCL5; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPHAE; INTERFERON-GAMMA; INTERLEUKIN-2; KILLER CELLS, NATURAL; SPORES, FUNGAL;

EID: 79751512293     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq062     Document Type: Article

References (24)

1. Dickinson AM, Harrold JL, Cullup H. Haematopoietic stem cell transplantation: can our genes predict clinical outcome? Expert Rev Mol Med 2007; 9:1-19.
2. Kontoyiannis DP, Marr KA, Park BJ, et al. Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) database. Clin Infect Dis 2010; 50:1091-100.
3. Passweg JR, Koehl U, Uharek L, Meyer-Monard S, Tichelli A. Naturalkiller-cell-based treatment in haematopoietic stem-cell transplantation. Best Pract Res Clin Haematol 2006; 19:811-24. (Pubitemid 44424290)
4. Gill S, Olson JA, Negrin RS. Natural killer cells in allogeneic transplantation: effect on engraftment, graft- versus-tumor, and graft-versus-host responses. Biol Blood Marrow Transplant 2009; 15:765-76.
5. Ruggeri L, Mancusi A, Capanni M, et al. Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value. Blood 2007; 110:433-40. (Pubitemid 47026866)
6. Newman KC, Riley EM. Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens. Nat Rev Immunol 2007; 7:279-91.
7. Morrison BE, Park SJ, Mooney JM, Mehrad B. Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. J Clin Invest 2003; 112:1862-70. (Pubitemid 38063709)
8. Park SJ, Hughes MA, Burdick M, Strieter RM, Mehrad B. Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis. J Immunol 2009; 182:4306-12.
9. Pagano L, Caira M, Nosari A, et al. Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study - Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne. Clin Infect Dis 2007; 45:1161-70. (Pubitemid 47580314)
10. Brill KJ, Li Q, Larkin R, et al. Human natural killer cells mediate killing of intracellular Mycobacterium tuberculosis H37Rv via granule-independent mechanisms. Infect Immun 2001; 69:1755-65. (Pubitemid 32187635)
11. Serbina NV, Cherny M, Shi C, et al. Distinct responses of human monocyte subsets to Aspergillus fumigatus conidia. J Immunol 2009; 183:2678-87.
12. Aimanianda V, Bayry J, Bozza S, et al. Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 2009; 460:1117-21.
13. Beck O, Topp MS, Koehl U, et al. Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus. Blood 2006; 107:2562-9. (Pubitemid 43345583)
14. Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH. NK cells use perforin rather than granulysin for anticryptococcal activity. J Immunol 2004; 173:3357-65.
15. Huenecke S, Zimmerman SY, Kloess S, et al. IL-2-driven regulation of NK cell receptors with regard to the distribution of CD161 and CD16-subpopulations and in vivo influence after haploidentical NK cell infusion. J Immunother 2010; 33:200-210.
16. Rubnitz JE, Inaba H, Ribeiro RC, et al. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol 2010; 28:955-9.
17. Miller JS, Soignier Y, Panoskaltsis-Mortari A, et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 2005; 105:3051-7.
18. Marr KJ, Jones GJ, Zheng C, et al. Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity. Infect Immun 2009; 77:2436-46.
19. Gil-Lamaignere C, Simitsopoulou M, Roilides E, Maloukou A, Winn RM, Walsh TJ. Interferon- gamma and granulocyte-macrophage colony-stimulating factor augment the activity of polymorphonuclear leukocytes against medically important zygomycetes. J Infect Dis 2005; 191:1180-7. (Pubitemid 40404378)
20. Uicker WC, Doyle HA, McCracken JP, Langlois M, Buchanan KL. Cytokine and chemokine expression in the central nervous system associated with protective cell-mediated immunity against Cryptococcus neoformans. Med Mycol 2005; 43:27-38. (Pubitemid 40192598)
21. Kawakami K, Koguchi Y, Qureshi MH, et al. NK cells eliminate Cryptococcus neoformans by potentiating the fungicidal activity of macrophages rather than by directly killing them upon stimulation with IL-12 and IL-18. Microbiol Immunol 2000; 44:1043-50. (Pubitemid 32011552)
22. Murciano C, Villamon E, O'Connor JE, Gozalbo D, Gil ML. Killed Candida albicans yeasts and hyphae inhibit gamma interferon release by murine natural killer cells. Infect Immun 2006; 74:1403-6. (Pubitemid 43185583)
23. Wichmann G, Herbarth O, Lehmann I. The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells. Environ Toxicol 2002; 17:211-8. (Pubitemid 34784966)
24. Safdar A, Rodriguez GH, Lichtiger B, et al. Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions. Cancer 2006; 106:2664-71.