Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans

European Journal of Applied Physiology

Volumn 111, Issue 2, 2011, Pages 203-210

  Rakobowchuk, Mark ^a   Crozier, Jennifer ^a   Glover, Elisa I ^a   Yasuda, Nobuo ^a   Phillips, Stuart M ^a   Tarnopolsky, Mark A ^a   MacDonald, Maureen J ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Blood flow; Deconditioning; Endothelial function

Indexed keywords

ADULT; ARTICLE; BLOOD FLOW; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FEMORAL ARTERY; HEART RATE; HEMODYNAMICS; HISTOLOGY; HUMAN; IMMOBILIZATION; LEG; MALE; ORGAN SIZE; PHYSIOLOGY; POPLITEAL ARTERY; RANDOMIZED CONTROLLED TRIAL; REST; TIME; VASCULAR RESISTANCE; VASCULARIZATION;

ADULT; BLOOD FLOW VELOCITY; BLOOD PRESSURE; FEMALE; FEMORAL ARTERY; HEART RATE; HEMODYNAMICS; HUMANS; IMMOBILIZATION; LEG; MALE; ORGAN SIZE; POPLITEAL ARTERY; REGIONAL BLOOD FLOW; REST; TIME FACTORS; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 79651472393     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-010-1636-y     Document Type: Article

References (23)

1. G Atkinson AM Batterham MA Black NT Cable ND Hopkins EA Dawson DH Thijssen H Jones TM Tinken DJ Green 2009 Is the ratio of flow-mediated dilation and shear rate a statistically sound approach to normalization in cross-sectional studies on endothelial function? J Appl Physiol 107 1893 1899 10.1152/japplphysiol.00779.2009 19833808
2. MW Bleeker PC De Groot F Poelkens GA Rongen P Smits MT Hopman 2005 Vascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension Am J Physiol Heart Circ Physiol 288 H1747 H1755 1:CAS:528: DC%2BD2MXjtlOrtLc%3D 10.1152/ajpheart.00966.2004 15576435 (Pubitemid 40418000)
3. MW Bleeker PC De Groot GA Rongen J Rittweger D Felsenberg P Smits MT Hopman 2005 Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin bed rest study J Appl Physiol 99 1293 1300 10.1152/japplphysiol.00118.2005 15932956 (Pubitemid 43014332)
4. MW Bleeker M Kooijman GA Rongen MT Hopman P Smits 2006 Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle J Physiol 565 685 694 10.1113/jphysiol.2005.085936
5. AM Dart BA Kingwell 2001 Pulse pressure-a review of mechanisms and clinical relevance J Am Coll Cardiol 37 975 984 1:STN:280:DC%2BD3M7mtlKruw%3D%3D 10.1016/S0735-1097(01)01108-1 11263624 (Pubitemid 32217593)
6. PC de Groot DH Van Kuppevelt C Pons G Snoek LH Van Der Woude MT Hopman 2003 Time course of arterial vascular adaptations to inactivity and paralyses in humans Med Sci Sports Exerc 35 1977 1985 10.1249/01.MSS.0000099088.21547.67 14652491 (Pubitemid 37509695)
7. PC de Groot F Poelkens M Kooijman MT Hopman 2004 Preserved flow-mediated dilation in the inactive legs of spinal cord-injured individuals Am J Physiol Heart Circ Physiol 287 H374 H380 10.1152/ajpheart.00958.2003 14988075 (Pubitemid 38802373)
8. P de Groot J Crozier M Rakobowchuk M Hopman M MacDonald 2005 Electrical stimulation alters FMD and arterial compliance in extremely inactive legs Med Sci Sports Exerc 37 1356 1364 10.1249/01.mss.0000174890.13395.e7 16118583 (Pubitemid 41209290)
9. FA Dinenno H Tanaka KD Monahan CM Clevenger I Eskurza CA DeSouza DR Seals 2001 Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men J Physiol 534 287 295 1:CAS:528: DC%2BD3MXltlejtLY%3D 10.1111/j.1469-7793.2001.00287.x 11433009 (Pubitemid 32631773)
10. GA Dudley MR Duvoisin GR Adams RA Meyer AH Belew P Buchanan 1992 Adaptations to unilateral lower limb suspension in humans Aviat Space Environ Med 63 678 683 1:STN:280:DyaK38znvVGmuw%3D%3D 1510640
11. C Giannattasio M Failla A Grappiolo M Bigoni S Carugo M Denti G Mancia 1998 Effects of prolonged immobilization of the limb on radial artery mechanical properties Hypertension 32 584 587 1:STN:280:DyaK1cvhtlaiug%3D%3D 9740631 (Pubitemid 28429154)
12. RA Harris SK Nishiyama DW Wray RS Richardson 2010 Ultrasound assessment of flow-mediated dilation Hypertension 55 1075 1085 1:CAS:528: DC%2BC3cXkslOjt70%3D 10.1161/HYPERTENSIONAHA.110.150821 20351340
13. JL Jasperse MH Laughlin 2006 Endothelial function and exercise training: evidence from studies using animal models Med Sci Sports Exerc 38 445 454 10.1249/01.mss.0000191187.24525.f2 16540831 (Pubitemid 43364119)
14. R Kelly C Hayward A Avolio M O'Rourke 1989 Noninvasive determination of age-related changes in the human arterial pulse Circulation 80 1652 1659 1:STN:280:DyaK3c%2FptV2hug%3D%3D 2598428 (Pubitemid 20031695)
15. M Miyachi M Iemitsu M Okutsu S Onodera 1998 Effects of endurance training on the size and blood flow of the arterial conductance vessels in humans Acta Physiol Scand 163 13 16 1:CAS:528:DyaK1cXksFymsrw%3D 10.1046/j.1365-201x.1998. 0337f.x 9648618 (Pubitemid 28264339)
16. P Norsk M Damgaard L Petersen M Gybel B Pump A Gabrielsen NJ Christensen 2006 Vasorelaxation in space Hypertension 47 69 73 1:CAS:528:DC%2BD2MXhtlSqu7fI 10.1161/01.HYP.0000194332.98674.57 16301338 (Pubitemid 43177817)
17. JL Olive GA Dudley KK McCully 2003 Vascular remodeling after spinal cord injury Med Sci Sports Exerc 35 901 907 10.1249/01.MSS.0000069755.40046.96 12783036 (Pubitemid 36706276)
18. M Rakobowchuk CL McGowan PC de Groot D Bruinsma JW Hartman SM Phillips MJ Macdonald 2005 Effect of whole body resistance training on arterial compliance in young healthy males Exp Physiol 90 645 651 1:STN:280:DC%2BD2MzktF2nsw%3D%3D 10.1113/expphysiol.2004.029504 15849230 (Pubitemid 40980166)
19. M Rakobowchuk S Tanguay KA Burgomaster KR Howarth MJ Gibala MJ Macdonald 2008 Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow mediated dilation in healthy humans Am J Physiol Regul Integr Comp Physiol 295 R236 R242 1:CAS:528:DC%2BD1cXoslyntrs%3D 18434437
20. J Sugawara K Hayashi F Kaneko H Yamada T Kizuka H Tanaka 2004 Reductions in basal limb blood flow and lumen diameter after short-term leg casting Med Sci Sports Exerc 36 1689 1694 10.1249/01.MSS.0000142410.45142.28 15595288 (Pubitemid 39332285)
21. H Tanaka FA Dinenno KD Monahan CM Clevenger CA DeSouza DR Seals 2000 Aging, habitual exercise, and dynamic arterial compliance Circulation 102 1270 1275 1:CAS:528:DC%2BD3cXntFCgt7w%3D 10982542
22. ML Urso PM Clarkson TB Price 2006 Immobilization effects in young and older adults Eur J Appl Physiol 96 564 571 1:STN:280:DC%2BD287ksFCmsA%3D%3D 10.1007/s00421-005-0109-1 16369818
23. N Yasuda EI Glover SM Phillips RJ Isfort MA Tarnopolsky 2005 Sex-based differences in skeletal muscle function and morphology with short-term limb immobilization J Appl Physiol 99 1085 1092 10.1152/japplphysiol.00247.2005 15860685 (Pubitemid 41214527)