CT imaging of acute pulmonary embolism

Journal of Cardiovascular Computed Tomography

Volumn 5, Issue 1, 2011, Pages 3-11

  Henzler, Thomas ^a,b   Barraza, J Michael ^a   Nance, John W ^a   Costello, Philip ^a   Krissak, Radko ^b   Fink, Christian ^b   Schoepf, U Joseph ^a,c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Computed tomography; Outcome studies; Pulmonary embolism; Pulmonary perfusion; Pulmonary thromboembolism; Right heart failure

Indexed keywords

ALGORITHM; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC TEST ACCURACY STUDY; HUMAN; LUNG ANGIOGRAPHY; LUNG EMBOLISM; LUNG PERFUSION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

EID: 79651471111     PISSN: 19345925     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcct.2010.10.001     Document Type: Review

References (68)

1. Geerts W.H., Pineo G.F., Heit J.A., Bergqvist D., Lassen M.R., Colwell C.W., Ray J.G. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004, 126(3 Suppl):338S-400S.
2. Goldhaber S.Z. Pulmonary embolism. Lancet 2004, 363:1295-1305.
3. Remy-Jardin M., Pistolesi M., Goodman L.R., Gefter W.B., Gottschalk A., Mayo J.R., Sostman H.D. Management of suspected acute pulmonary embolism in the era of CT angiography: a statement from the Fleischner Society. Radiology 2007, 245:315-329.
4. Schoepf U.J., Costello P. CT angiography for diagnosis of pulmonary embolism: state of the art. Radiology 2004, 230:329-337.
5. Ghaye B., Szapiro D., Mastora I., Delannoy V., Duhamel A., Remy J., Remy-Jardin M. Peripheral pulmonary arteries: how far in the lung does multi-detector row spiral CT allow analysis?. Radiology 2001, 219:629-636.
6. Schoepf U.J., Goldhaber S.Z., Costello P. Spiral computed tomography for acute pulmonary embolism. Circulation 2004, 109:2160-2167.
7. Torbicki A., Perrier A., Konstantinides S., Agnelli G., Galie N., Pruszczyk P., Bengel F., Brady A.J., Ferreira D., Janssens U., Klepetko W., Mayer E., Remy-Jardin m, Bassand J.P., Vahanian A., Camm J., De Caterina R., Dean V., Dickstein K., Filippatos G., Funch-Brentano C., Hellemans I., Kristensen S.D., McGregor K., Sechtern U., Silber S., Tendera M., Widimsky P., Zamorano J.L., Zamorano J.L., Andreotti F., Ascherman M., Athanassopoulos G., De Sutter J., Fitzmaurice D., Forster T., Heras M., Jondeau G., Kjeldsen K., Knuuti J., Lang I., Lenzen M., Lopez-Sendon J., Nihoyannopoulos P., Perez Isla I., Schwehr U., Torraca L., Vachiery L.J. Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology: Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2008, 29:2276-2315.
8. Kreit J.W. The impact of right ventricular dysfunction on the prognosis and therapy of normotensive patients with pulmonary embolism. Chest 2004, 125:1539-1545.
9. Leacche M., Unic D., Goldhaber S.Z., Rawn J.D., Aranki S.S.F., Couper G.S., Mihaljevic T., Rizzo R.J., Cohn L.H., Aklog L., Byrne J.G. Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach. J Thorac Cardiovasc Surg 2005, 129:1018-1023.
10. Remy-Jardin M., Remy J., Wattinne L., Giraud F. Central pulmonary thromboembolism: diagnosis with spiral volumetric CT with the single-breath-hold technique-comparison with pulmonary angiography. Radiology 1992, 185:381-387.
11. Ferretti G.R., Bosson J.L., Buffaz P.D., Ayanian D., Pison C., Blanc F., Carpentier F., Carpentier P., Coulomb M. Acute pulmonary embolism: role of helical CT in 164 patients with intermediate probability at ventilation-perfusion scintigraphy and normal results at duplex US of the legs. Radiology 1997, 205:453-458.
12. Garg K., Welsh C.H., Feyerabend A.J., Subber S.W., Russ P.D., Johnston R.J., Durham J.D., Lynch D.A. Pulmonary embolism: diagnosis with spiral CT and ventilation-perfusion scanning-correlation with pulmonary angiographic results or clinical outcome. Radiology 1998, 208:201-208.
13. Kim K.I., Muller N.L., Mayo J.R. Clinically suspected pulmonary embolism: utility of spiral CT. Radiology 1999, 210:693-697.
14. Remy-Jardin M., Remy J., Baghaie F., Fribourg M., Artaud D., Duhamel A. Clinical value of thin collimation in the diagnostic workup of pulmonary embolism. AJR Am J Roentgenol 2000, 175:407-411.
15. Perrier A., Howarth N., Didier D., Loubeyre P., Unger P.F., de Moerlosse P., Slosman D., Junod A., Bounameaux H. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism. Ann Intern Med 2001, 135:88-97.
16. Oser R.F., Zuckerman D.A., Gutierrez F.R., Brink J.A. Anatomic distribution of pulmonary emboli at pulmonary angiography: implications for cross-sectional imaging. Radiology 1996, 199:31-35.
17. Patriquin L., Khorasani R., Polak J.F. Correlation of diagnostic imaging and subsequent autopsy findings in patients with pulmonary embolism. AJR Am J Roentgenol 1998, 171:347-349.
18. Tillie-Leblond I., Marquette C.H., Perez T., Scherpereel A., Zanetti C., Tonnel A.B., Remy-Jardin M. Pulmonary embolism in patients with unexplained exacerbation of chronic obstructive pulmonary disease: prevalence and risk factors. Ann Intern Med 2006, 144:390-396.
19. Eng J., Krishnan J.A., Segal J.B., Bolger D.T., Tamariz L.J., Streiff M.B., Jenckes M.W., Bass E.B. Accuracy of CT in the diagnosis of pulmonary embolism: a systematic literature review. AJR Am J Roentgenol 2004, 183:1819-1827.
20. Safriel Y., Zinn H. CT pulmonary angiography in the detection of pulmonary emboli: a meta-analysis of sensitivities and specificities. Clin Imaging 2002, 26:101-105.
21. Qanadli S.D., Hajjam M.E., Mesurolle B., Barre O., Bruckert F., Joseph T., Mignon F., Vieillard-Baron A., Dubourg O., Lacombe P. Pulmonary embolism detection: prospective evaluation of dual-section helical CT versus selective pulmonary arteriography in 157 patients. Radiology 2000, 217:447-455.
22. Winer-Muram H.T., Rydberg J., Johnson M.S., Tarver R.D., Williams M.D., Shah H., Namyslowski J., Conces D., Jennings S.G., Ying J., Trerotola S.O., Kopecky K.K. Suspected acute pulmonary embolism: evaluation with multi-detector row CT versus digital subtraction pulmonary arteriography. Radiology 2004, 233:806-815.
23. Stein P.D., Fowler S.E., Goodman L.R., Gottschalk A., Hales C.A., Hull R.D., Leeper K.V., Popovich J., Quinn D.A., Sos T.A., Sostman H.D., Tapson V.F., Wakefield T.W., Weg J.G., Woodard P.K. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med 2006, 354:2317-2327. PIOPED II Investigators.
24. Ruiz Y., Caballero P., Caniego J.L., Friera A., Olivera M.J., Tagarro D., Alvarez-Sala R. Prospective comparison of helical CT with angiography in pulmonary embolism: global and selective vascular territory analysis. Interobserver agreement. Eur Radiol 2003, 13:823-829.
25. Douma R.A., Hofstee H.M., Schaefer-Prokop C., van Waesberghe J.H., Lely R.J., Kamphuisen P.W., Gerdes V.E., Kramer M.H., Büller H.R. Comparison of 4- and 64-slice CT scanning in the diagnosis of pulmonary embolism. Thromb Haemost 2010, 103:242-246.
26. Quiroz R., Kucher N., Zou K.H., Kipfmueller F., Costello P., Goldhaber S.Z., Schoepf U.J. Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic review. JAMA 2005, 293:2012-2017.
27. Perrier A., Roy P.M., Sanchez O., Le Gal G., Meyer G., Gourdier A.L., Furber A., Revel M.P., Howarth N., Davido A., Bounameaux H. Multidetector-row computed tomography in suspected pulmonary embolism. N Engl J Med 2005, 352:1760-1768.
28. Gurney J.W. No fooling around: direct visualization of pulmonary embolism. Radiology 1993, 188:618-619.
29. Hull R.D., Raskob G.E., Ginsberg J.S., Panju A.A., Brill-Edwards P., Coates G., Pineo G.F. A noninvasive strategy for the treatment of patients with suspected pulmonary embolism. Arch Intern Med 1994, 154:289-297.
30. Blachere H., Latrabe V., Montaudon M., Valli N., Couffinhal T., Raherisson C., Leccia F., Laurent F. Pulmonary embolism revealed on helical CT angiography: comparison with ventilation-perfusion radionuclide lung scanning. AJR Am J Roentgenol 2000, 174:1041-1047.
31. Remy-Jardin M., Tillie-Leblond I., Szapiro D., Ghaye B., Cotte L., Mastora I., Delannoy V., Remy J. CT angiography of pulmonary embolism in patients with underlying respiratory disease: impact of multislice CT on image quality and negative predictive value. Eur Radiol 2002, 12:1971-1978.
32. Goodman L.R., Lipchik R.J., Kuzo R.S., Liu Y., McAuliffe T.L., O'Brien D.J. Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram-prospective comparison with scintigraphy. Radiology 2000, 215:535-542.
33. Garg K., Sieler H., Welsh C.H., Johnston R.J., Russ P.D. Clinical validity of helical CT being interpreted as negative for pulmonary embolism: implications for patient treatment. AJR Am J Roentgenol 1999, 172:1627-1631.
34. Gottsater A., Berg A., Centergard J., Frennby B., Nirhov N., Nyman U. Clinically suspected pulmonary embolism: is it safe to withhold anticoagulation after a negative spiral CT?. Eur Radiol 2001, 11:65-72.
35. Ost D., Rozenshtein A., Saffran L., Snider A. The negative predictive value of spiral computed tomography for the diagnosis of pulmonary embolism in patients with nondiagnostic ventilation-perfusion scans. Am J Med 2001, 110:16-21.
36. Swensen S.J., Sheedy P.F., Ryu J.H., Pickett D.D., Schleck C.D., Ilstrup D.M., Heit J.A. Outcomes after withholding anticoagulation from patients with suspected acute pulmonary embolism and negative computed tomographic findings: a cohort study. Mayo Clin Proc 2002, 77:130-138.
37. Schoepf U.J., Holzknecht N., Helmberger T.K., Crispin A., Hong C., Becker C.R., Reiser M.F. Subsegmental pulmonary emboli: improved detection with thin-collimation multi-detector row spiral CT. Radiology 2002, 222:483-490.
38. Henzler T, Meyer M, Reichert M, Krissak R, Nance JW Jr, Haneder S, Schoenberg SO, Fink C: Dual-energy CT angiography of the lungs: Comparison of test bolus and bolus tracking techniques for the determination of scan delay [Prepublished ahead of print July 2, 2010]. Eur J Radiol. doi: doi:10.1016/j.ejrad.2010.06.023.
39. Kirchner J., Kickuth R., Laufer U., Noack M., Liermann D. Optimized enhancement in helical CT: experiences with a real-time bolus tracking system in 628 patients. Clin Radiol 2000, 55:368-373.
40. Krissak R., Henzler T., Reichert M., Krauss B., Schoenberg S.O., Fink C. Enhanced visualization of lung vessels for diagnosis of pulmonary embolism using dual energy CT angiography. Invest Radiol 2010, 45:341-346.
41. Fink C., Johnson T.R., Michaely H.J., Morhard D., Becker C., Reiser M., Nikolaou K. Dual-energy CT angiography of the lung in patients with suspected pulmonary embolism: initial results. Rofo 2008, 180:879-883.
42. Takakuwa K.M., Halpern E.J., Gingold E.L., Levin D.C., Shofer F.S. Radiation dose in a " triple rule-out" coronary CT angiography protocol of emergency department patients using 64-MDCT: the impact of ECG-based tube current modulation on age, sex, and body mass index. AJR Am J Roentgenol 2009, 192:866-872.
43. Resten A., Mausoleo F., Valero M., Musset D. Comparison of doses for pulmonary embolism detection with helical CT and pulmonary angiography. Eur Radiol 2003, 13:1515-1521.
44. Parker M.S., Hui F.K., Camacho M.A., Chung J.K., Broga D.W., Sethi N.N. Female breast radiation exposure during CT pulmonary angiography. AJR Am J Roentgenol 2005, 185:1228-1233.
45. Schoepf U.J., Bruening R., Konschitzky H., Becker C.R., Knez A., Weber J., Muehling O., Herzog P., Huber A., Haberl R., Reiser M.F. Pulmonary embolism: comprehensive diagnosis by using electron-beam CT for detection of emboli and assessment of pulmonary blood flow. Radiology 2000, 217:693-700.
46. Wildberger J.E., Niethammer M.U., Klotz E., Schaller S., Wein B.B., Gunther R.W. Multi-slice CT for visualization of pulmonary embolism using perfusion weighted color maps. Rofo 2001, 173:289-294.
47. Wildberger J.E., Klotz E., Ditt H., Spuntrup E., Mahnken A.H., Gunther R.W. Multislice computed tomography perfusion imaging for visualization of acute pulmonary embolism: animal experience. Eur Radiol 2005, 15:1378-1386.
48. Johnson T.R., Krauss B., Sedlmair M., Grasruck M., Bruder H., Morhard D., Fink C., Weckbach S., Lenhard M., Schmidt B., Flohr T., Reiser M.F., Becker C.R. Material differentiation by dual energy CT: initial experience. Eur Radiol 2007, 17:1510-1517.
49. Thieme S.F., Becker C.R., Hacker M., Nikolaou K., Reiser M.F., Johnson T.R. Dual energy CT for the assessment of lung perfusion-correlation to scintigraphy. Eur J Radiol 2008, 68:369-374.
50. Thieme S.F., Johnson T.R., Lee C., McWilliams J., Becker C.R., Reiser M.F., Nicolaou K. Dual-energy CT for the assessment of contrast material distribution in the pulmonary parenchyma. AJR Am J Roentgenol 2009, 193:144-149.
51. Pontana F., Faivre J.B., Remy-Jardin M., Flohr T., Schmidt B., Tacelli N., Pansini V., Remy J. Lung perfusion with dual-energy multidetector-row CT (MDCT): feasibility for the evaluation of acute pulmonary embolism in 117 consecutive patients. Acad Radiol 2008, 15:1494-1504.
52. Chae E.J., Seo J.B., Jang Y.M., Krauss B., Lee C.W., Lee H.J., Song K.S. Dual-energy CT for assessment of the severity of acute pulmonary embolism: pulmonary perfusion defect score compared with CT angiographic obstruction score and right ventricular/left ventricular diameter ratio. AJR Am J Roentgenol 2010, 194:604-610.
53. Araoz P.A., Gotway M.B., Harrington J.R., Harmsen W.S., Mandrekar J.N. Pulmonary embolism: prognostic CT findings. Radiology 2007, 242:889-897.
54. Ghaye B., Ghuysen A., Willems V., Lambermont B., Gerard P., D'Orio V., Gevenois P.A., Dondelinger R.F. Severe pulmonary embolism:pulmonary artery clot load scores and cardiovascular parameters as predictors of mortality. Radiology 2006, 239:884-891.
55. Ghuysen A., Ghaye B., Willems V., Lambermont B., Gerard P., Dondelinger R.F., D'Orio V. Computed tomographic pulmonary angiography and prognostic significance in patients with acute pulmonary embolism. Thorax 2005, 60:956-961.
56. Mansencal N, Joseph T, Vieillard-Baron A, Langlois S, El Hajjam M, Qanadli SD, Lacombe P, Dubourg O: Diagnosis of right ventricular dysfunction in acute pulmo. 2005;95:1260-1263.
57. Quiroz R., Kucher N., Schoepf U.J., Kipfmueller F., Solomon S.D., Costello P., Goldhaber S.Z. Right ventricular enlargement on chest computed tomography: prognostic role in acute pulmonary embolism. Circulation 2004, 109:2401-2404.
58. Schoepf U.J., Kucher N., Kipfmueller F., Quiroz R., Costello P., Goldhaber S.Z. Right ventricular enlargement on chest computed tomography: a predictor of early death in acute pulmonary embolism. Circulation 2004, 110:3276-3280.
59. van der Meer R.W., Pattynama P.M., van Strijen M.J., van den Berg-Huijsmans A.A., Hartmann I.J., Putter H., de Roos A., Hiusman M.V. Right ventricular dysfunction and pulmonary obstruction index at helical CT: prediction of clinical outcome during 3-month follow-up in patients with acute pulmonary embolism. Radiology 2005, 235:798-803.
60. Dogan H., Kroft L.J., Huisman M.V., van der Geest R.J., de Roos A. Right ventricular function in patients with acute pulmonary embolism: analysis with electrocardiography-synchronized multi-detector row CT. Radiology 2007, 242:78-84.
61. Henzler T., Krissak R., Reichert M., Sueselbeck T., Schoenberg S.O., Fink C. Volumetric analysis of pulmonary CTA for the assessment of right ventricular dysfunction in patients with acute pulmonary embolism. Acad Radiol 2010, 17:309-315.
62. Collomb D., Paramelle P.J., Calaque O., Bosson J.L., Vanzetto G., Barnoud D., Pison C., Coulomb M., Ferretti G. Severity assessment of acute pulmonary embolism: evaluation using helical CT. Eur Radiol 2003, 13:1508-1514.
63. Contractor S., Maldjian P.D., Sharma V.K., Gor D.M. Role of helical CT in detecting right ventricular dysfunction secondary to acute pulmonary embolism. J Comput Assist Tomogr 2002, 26:587-591.
64. Lim K.E., Chan C.Y., Chu P.H., Hsu Y.Y., Hsu W.C. Right ventricular dysfunction secondary to acute massive pulmonary embolism detected by helical computed tomography pulmonary angiography. Clin Imaging 2005, 29:16-21.
65. Gosselin M.V., Rubin G.D. Altered intravascular contrast material flow dynamics: clues for refining thoracic CT diagnosis. AJR Am J Roentgenol 1997, 169:1597-1603.
66. He H., Stein M.W., Zalta B., Haramati L.B. Computed tomography evaluation of right heart dysfunction in patients with acute pulmonary embolism. J Comput Assist Tomogr 2006, 30:262-266.
67. Araoz P.A., Gotway M.B., Trowbridge R.L., Bailey R.A., Auerbach A.D., Reddy G.P., Dawn S.K., Webb W.R., Higgins C.B. Helical CT pulmonary angiography predictors of in-hospital morbidity and mortality in patients with acute pulmonary embolism. J Thorac Imaging 2003, 18:207-216.
68. Lu M.T., Cai T., Ersoy H., Whitmore A.G., Levit N.A., Goldhaber S.Z., Rybicki F.J. Comparison of ECG-gated versus non-gated CT ventricular measurements in thirty patients with acute pulmonary embolism. Int J Cardiovasc Imaging 2009, 25:101-107.