Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B′s role in nitric oxide synthase

Journal of the American Chemical Society

Volumn 133, Issue 5, 2011, Pages 1172-1175

  Liu, Haining ^a   Walker, Larry A ^a,b   Nanayakkara, N P Dhammika ^a   Doerksen, Robert J ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8-AMINOQUINOLINE; ANTIMALARIAL DRUG; DFT CALCULATION; METHEMOGLOBINEMIA; NITRIC-OXIDE SYNTHASE;

IRON COMPOUNDS;

NITRIC OXIDE;

5 HYDROXY 6 NORPRIMAQUINE; 8 AMINOQUINOLINE DERIVATIVE; HEMOGLOBIN; METHEMOGLOBIN; NITRIC OXIDE SYNTHASE;

ARTICLE; BLOOD TOXICITY; CALCULATION; DENSITY FUNCTIONAL THEORY; DRUG DESIGN; ELECTRON; METHEMOGLOBINEMIA; PROTEIN FUNCTION;

AMINOQUINOLINES; ANTIMALARIALS; BIOPTERIN; HEMOGLOBINS; METHEMOGLOBINEMIA; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE; PROTEIN CONFORMATION; PROTONS; QUANTUM THEORY;

EID: 79551706067     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja107472c     Document Type: Article

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