Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core

Applied Radiation and Isotopes

Volumn 69, Issue 4, 2011, Pages 663-669

  Fernández Núñez, Eutimio Gustavo ^a   Linkowski Faintuch, Bluma ^a   Teodoro, Rodrigo ^a   Pereira Wiecek, Danielle ^a   da Silva, Natanael Gomes ^a   Papadopoulos, Minas ^b   Pelecanou, Maria ^b   Pirmettis, Ioannis ^b   de Oliveira Filho, Renato Santos ^c   Duatti, Adriano ^d   Pasqualini, Roberto ^e  

^a INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF FERRARA   (Italy)

^e CIS Bio International   (France)

Author keywords

99mTc(OH2)3(CO)3 + precursor; Dextran; Experimental design; Radiolabeling; Statistical analysis; Technetium

Indexed keywords

[99MTC(OH2)3(CO)3]+ PRECURSOR; EXPERIMENTAL DESIGN; PARAMETERS OPTIMIZATION; RADIOLABELING; SENTINEL LYMPH NODES; SPECIFIC ACTIVITY; STATISTICAL ANALYSIS; STATISTICAL APPROACH; THREE-LEVEL FACTORIAL DESIGN;

AMINO ACIDS; DESIGN; DEXTRAN; GLUCOSE; OPTIMIZATION; PROPYLENE; TECHNETIUM;

STATISTICS;

TECHNETIUM 2 PROPYLENE S CYSTEINE DEXTRAN TC 99M; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG PURITY; DRUG STABILITY; DRUG STRUCTURE; EX VIVO STUDY; FACTORIAL DESIGN; FEMALE; ISOTOPE ANALYSIS; ISOTOPE LABELING; LYMPHOSCINTIGRAPHY; MOLECULAR STABILITY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; RADIOACTIVITY; RADIOCHEMISTRY; RAT; SENTINEL LYMPH NODE; STATISTICAL ANALYSIS;

CHROMATOGRAPHY, GEL; CYSTEINE; DEXTRANS; ORGANOTECHNETIUM COMPOUNDS; QUALITY CONTROL;

EID: 79551690185     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2011.01.006     Document Type: Article

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