[11C]diclofenac sodium: Synthesis and PET assessment of transdermal penetration

Nuclear Medicine and Biology

Volumn 38, Issue 2, 2011, Pages 181-189

  Petroni, Debora ^a   Menichetti, Luca ^a   Sorace, Oreste ^a   Poli, Michela ^a   Vanasia, Massimo ^b   Salvadori, Piero A ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b GiEnne Pharma   (Italy)

Author keywords

Carbon 11; Diclofenac; PET; Transdermal penetration

Indexed keywords

CARBON 11; DICLOFENAC; CARBON; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEASIBILITY STUDY; HUMAN; HUMAN EXPERIMENT; ISOTOPE LABELING; ISOTOPE TRACING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKIN PENETRATION; CLINICAL TRIAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; SYNTHESIS;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICLOFENAC; FEASIBILITY STUDIES; HUMANS; POSITRON-EMISSION TOMOGRAPHY;

EID: 79551683046     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.08.005     Document Type: Article

References (11)

1. Özgüney I.S., Karasulu H.Y., Kantarci G., Sözer S., Güneri T., Ertan G. Transdermal delivery of diclofenac sodium through rat skin from various formulations. AAPS Pharma Sci Tech 2006, 7:E1-E7.
2. Piao H., Kamiya N., Hirata A., Fuji T., Goto M. A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium. Pharm Research 2008, 25(4):896-901.
3. Sallmann AR, Pfister R. Substituted derivatives of 2-anilino-phenylacetic acids and process of preparation. US Patent 3,558,690, 1971.
4. Sallmann AR, Pfister R. Chemical intermediates for the production of substituted 2-anilinophenyl-acetic acids and esters. US Patent 3,778,470, 1973.
5. Sallmann A.R. The history of diclofenac. Am J Med 1986, 80(Suppl 4B):29-33.
6. Todd P.A., Sorkin E.M. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1988, 35:244-285.
7. Leroy D., Richard J., Godbillon J. Synthesis of deuterium-labelled diclofenac sodium. J Label Comp Radiopharm 1993, 33(11):1019-1027.
8. 14C]diclofenac sodium). Chem Pharm Bull 1985, 33:5562-5564.
9. Nohara F. Process for preparation of o-(2,6-dichloroanilino)phenylacetic acid and novel intermediate for use in preparation of the same. US Patent 4,283,532, 1981.
10. Tamura Y., Uenishi J., Choi H.D., Haruta J., Ishibashi H. Synthesis of diclofenac. Chem. Pharm. Bull. 1983, 32(5):1995-1997.
11. Delacroix D., Guerre J., Leblanc P., Hickman C. Radionuclide and radiation protection data handbook 1998, radiation protection dosimetry. Vol. 76 Nos. 1-2 1998.