Suppression of intracellular calcium levels and inhibition of degranulation in RBL-2H3 mast cells by the sesquiterpene lactone parthenolide

Planta Medica

Volumn 77, Issue 3, 2011, Pages 252-256

  Hong, Jangja ^a,b   Aoyama, Suzue ^c   Hirasawa, Noriyasu ^c   Zee, Okpyo ^b   Ishihara, Kenji ^d   Hashida, Chika ^a   Kimura, Michio ^a   Seyama, Toshio ^a   Ohuchi, Kazuo ^a  

^a YASUDA WOMEN'S UNIVERSITY   (Japan)

^b Sungkyunkwan University   (South Korea)

^c TOHOKU UNIVERSITY   (Japan)

^d IBARAKI UNIVERSITY   (Japan)

Author keywords

hexosaminidase; Asteraceae; degranulation; intracellular calcium; parthenolide; RBL2H3 mast cells; Tanacetum parthenium (L.) Sch. Bip.

Indexed keywords

CALCIUM; PARTHENOLIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MAST CELL DEGRANULATION; NONHUMAN; RAT;

ANIMALS; ANTIGENS; CALCIUM; CELL DEGRANULATION; CELL LINE, TUMOR; IMMUNOLOGIC FACTORS; INHIBITORY CONCENTRATION 50; IONOMYCIN; MAST CELLS; PLANT EXTRACTS; RATS; SESQUITERPENES; TANACETUM;

ASTERACEAE; TANACETUM PARTHENIUM;

EID: 79551681382     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250221     Document Type: Article

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