Disseminated Mycobacterium genavense with pulmonary nodules in a kidney transplant recipient: Case report and review of the literature

Transplant Infectious Disease

Volumn 13, Issue 1, 2011, Pages 38-43

  Doggett, J S ^a   Strasfeld, L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

16S rRNA; Immunocompromised; Molecular diagnostics; Mycobacterium genavense; Non tuberculous mycobacteria; Pulmonary nodules; Transplant

Indexed keywords

AZITHROMYCIN; BASILIXIMAB; CREATININE; ETHAMBUTOL; GANCICLOVIR; MINOCYCLINE; MOXIFLOXACIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RIFABUTIN; TACROLIMUS;

ADULT; ARTICLE; BACTERIUM CULTURE; BLOOD CELL COUNT; BONE MARROW BIOPSY; BONE MARROW CULTURE; CASE REPORT; COLITIS; COMPUTER ASSISTED TOMOGRAPHY; CREATININE BLOOD LEVEL; CYTOMEGALOVIRUS INFECTION; DRUG WITHDRAWAL; FEVER; HEMATOCRIT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FAILURE; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; LEUKOPENIA; LUNG NODULE; LYMPHADENOPATHY; MALE; MYCOBACTERIOSIS; MYCOBACTERIUM GENAVENSE; MYCOBACTERIUM GENAVENSE INFECTION; NEUTROPENIA; NEUTROPHIL COUNT; NOCARDIOSIS; PNEUMONIA; PRIORITY JOURNAL; RNA ANALYSIS; TENDINITIS;

HUMANS; KIDNEY TRANSPLANTATION; LUNG; MALE; MIDDLE AGED; MULTIPLE PULMONARY NODULES; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA; TOMOGRAPHY SCANNERS, X-RAY COMPUTED;

EID: 79551679977     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2010.00545.x     Document Type: Article

References (32)

1. Tortoli E, Brunello F, Cagni AE, et al. Mycobacterium genavense in AIDS patients, report of 24 cases in Italy and review of the literature. Eur J Epidemiol 1998; 14 (3): 219-224.
2. Böttger EC, Teske A, Kirschner P, et al. Disseminated 'Mycobacterium genavense' infection in patients with AIDS. Lancet 1992; 340: 76-80.
3. Pechère M, Opravil M, Wald A, et al. Clinical and epidemiologic features of infection with Mycobacterium genavense. Swiss HIV Cohort Study. Arch Intern Med 1995; 155 (4): 400-404.
4. Thomsen VO, Dragsted UB, Bauer J, Fuursted K, Lundgren J. Disseminated infection with Mycobacterium genavense: a challenge to physicians and mycobacteriologists. J Clin Microbiol 1999; 37 (12): 3901-3905.
5. Liberek V, Soravia C, Ninet B, Hirschel B, Siegrist CA. Cervical lymphadenitis caused by Mycobacterium genavense in a healthy child. Pediatr Infect Dis J 1996; 15 (3): 269-270.
6. de Lastours V, Guillemain R, Mainardi JL, et al. Early diagnosis of disseminated Mycobacterium genavense infection. Emerg Infect Dis 2008; 14 (2): 346-347.
7. Nurmohamed S, Weenink A, Moeniralam H, Visser C, Bemelman F. Hyperammonemia in generalized Mycobacterium genavense infection after renal transplantation. Am J Transplant 2007; 7 (3): 722-723.
8. Lu KJ, Grigg A, Leslie D, Finlay M, Sasadeusz J. Mycobacterium genavense duodenitis following allogeneic peripheral blood stem cell transplantation. Transpl Infect Dis 2009; 11 (6): 534-536. [Epub 2009 July 28].
9. Bogdan C, Kern P, Richter E, et al. Systemic infection with Mycobacterium genavense following immunosuppressive therapy in a patient who was seronegative for human immunodeficiency virus. Clin Infect Dis 1997; 24 (6): 1245-1247.
10. Léautez S, Boutoille D, Bemer-Melchior P, Ponge T, Raffi F. Localized Mycobacterium genavense soft tissue infection in an immunodeficient HIV-negative patient. Eur J Clin Microbiol Infect Dis 2000; 19 (1): 51-52.
11. Krebs T, Zimmerli S, Bodmer T, Lämmle B. Mycobacterium genavense infection in a patient with long-standing chronic lymphocytic leukaemia. J Intern Med 2000; 248 (4): 343-348.
12. Lorenzen J, Meyer-Olson D, Haubitz M, et al. Infection with Mycobacterium genavense in a patient with systemic lupus erythematosus. Clin Rheumatol 2009; 28 (Suppl 1): S39-S41. [Epub 2009 February 28].
13. Sharifian A, Humphris J, Leong RW, Jones DB. Education and imaging. Gastrointestinal: Mycobacterium genavense enteritis in an immunosuppressed patient. J Gastroenterol Hepatol 2009; 24 (8): 1474.
14. Monill JM, Franquet T, Sambeat MA, Martínez-Noguera A, Villalba J. Mycobacterium genavense infection in AIDS: imaging findings in eight patients. Eur Radiol 2001; 11 (2): 193-196.
15. Dumonceau JM, Fonteyne PA, Realini L, Van Gossum A, Van Vooren JP, Portaels F. Species-specific Mycobacterium genavense DNA in intestinal tissues of individuals not infected with human immunodeficiency virus. J Clin Microbiol 1995; 33 (9): 2514-2515.
16. Kiehn TE, Hoefer H, Bottger EC, et al. Mycobacterium genavense infections in pet animals. J Clin Microbiol 1996; 34 (7): 1840-1842.
17. Hughes MS, Ball NW, Love DN, et al. Disseminated Mycobacterium genavense infection in a FIV-positive cat. J Feline Med Surg 1999; 1 (1): 23-29.
18. Lucas J, Lucas A, Furber H, et al. Mycobacterium genavense infection in two aged ferrets with conjunctival lesions. Aust Vet J 2000; 78 (10): 685-689.
19. Ludwig E, Reischl U, Janik D, Hermanns W. Granulomatous pneumonia caused by Mycobacterium genavense in a dwarf rabbit (Oryctolagus cuniculus). Vet Pathol 2009; 46 (5): 1000-1002. [Epub 2009 May 9].
20. Böttger EC. Mycobacterium genavense: an emerging pathogen. Eur J Clin Microbiol Infect Dis 1994; 13 (11): 932-936.
21. Yan JJ, Ko WC, Tsai HM, Jin YT, Su IJ. Disseminated Mycobacterium genavense infection in a patient with acquired immunodeficiency syndrome: first case report in Taiwan. J Formos Med Assoc 1999; 98 (1): 62-65.
22. Hirschel B, Chang HR, Mach N, et al. Fatal infection with a novel, unidentified mycobacterium in a man with the acquired immunodeficiency syndrome. N Engl J Med 1990; 323 (2): 109-113.
23. Fournier S, Pialoux G, Vincent V. Mycobacterium genavense and cutaneous disease in AIDS. Ann Intern Med 1998; 128 (5): 409.
24. Vergnaud M, Dauga C, Dompmartin A, Malbruny B, Bazin C, Grimont PA. Genital infection due to Mycobacterium genavense in a patient with AIDS. Clin Infect Dis 1998; 27 (6): 1531.
25. Berman SM, Kim RC, Haghighat D, Mulligan ME, Fierer J, Wyle FC. Mycobacterium genavense infection presenting as a solitary brain mass in a patient with AIDS: case report and review. Clin Infect Dis 1994; 19 (6): 1152-1154.
26. Douchette K, Fishman JA. Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients. Clin Infect Dis 2004; 38 (10): 1428-1439.
27. Matsiota-Bernard P, Vildé F, Nauciel C. Mycobacterium genavense infection in normal and immunodeficient mice. Microbes Infect 2000; 2 (6): 575-580.
28. Griffith DE, Aksamit T, Brown-Elliott BA, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007; 175 (4): 367-416.
29. Coyle MB, Carlson LC, Wallis CK, et al. Laboratory aspects of 'Mycobacterium genavense, ' a proposed species isolated from AIDS patients. J Clin Microbiol 1992; 30 (12): 3206-3212.
30. Realini L, De Ridder K, Palomino J, Hirschel B, Portaels F. Microaerophilic conditions promote growth of Mycobacterium genavense. J Clin Microbiol 1998; 36 (9): 2565-2570.
31. Realini L, Van Der Stuyft P, De Ridder K, Hirschel B, Portaels F. Inhibitory effects of polyoxyethylene stearate, PANTA, and neutral pH on growth of Mycobacterium genavense in BACTEC primary cultures. J Clin Microbiol 1997; 35 (11): 2791-2794.
32. Vrioni G, Nauciel C, Kerharo G, Matsiota-Bernard P. Treatment of disseminated Mycobacterium genavense infection in a murine model with ciprofloxacin, amikacin, ethambutol, clarithromycin and rifabutin. J Antimicrob Chemother 1998; 42 (4): 483-487.