Efficient aggregate removal from impure pharmaceutical active antibodies

BioProcess International

Volumn 9, Issue 2, 2011, Pages 36-42

  Ebert, Sybille ^a,b   Fischer Frühholz, Stefan ^a,b  

^a Rentschler Biotechnologie GmbHh ^*  (Germany)

^b SARTORIUS STEDIM BIOTECH GMBH   (Germany)

Author keywords

Disposables; Hydrophobic interaction chromatography; Laboratory scale; Polishing

Indexed keywords

ENDOTOXIN; MONOCLONAL ANTIBODY; PROTEIN A; RECOMBINANT DNA;

ANAPHYLAXIS; ANION EXCHANGE; ARTICLE; BINDING AFFINITY; CATION EXCHANGE; FIELD FLOW FRACTIONATION; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IMMUNOGLOBULIN AGGREGATE; LEACHING; PROCESS DEVELOPMENT; WASTE COMPONENT REMOVAL;

EID: 79551671058     PISSN: 15426319     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (6)

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3. Kuczewski M, et al. Development of a Polishing Step Using a Hydrophobic Interaction Membrane Adsorber with a PER.C6 - Derived Recombinant Antibody. Biotechnol. Bioeng. 105(2) 2010: 296-305.
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