Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.)

Phytotherapy Research

Volumn 25, Issue 2, 2011, Pages 195-201

  Saaby, Lasse ^a   Moesby, Lise ^a   Hansen, Erik Wind ^a   Christensen, Søren Brøgger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

interleukin 6; Mono Mac 6; Rosa canina L; rose hip powder; triterpene acid

Indexed keywords

BETULIC ACID; DEXAMETHASONE; DICHLOROMETHANE; IMMUNOMODULATING AGENT; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LITOMOVE; OLEANOLIC ACID; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; URSOLIC ACID;

ARTICLE; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; FRACTIONATION; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; POWDER; ROSE;

CELL LINE; CELL SURVIVAL; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; OLEANOLIC ACID; PLANT EXTRACTS; ROSA; TRITERPENES;

ROSA CANINA;

EID: 79551656280     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3241     Document Type: Article

References (24)

1. Barnes PJ, Adcock IM,. 2009. Glucocorticoid resistance in inflammatory diseases. Lancet 373: 1905-1917.
2. Bondeson J, Wainwright S, Lauder S, Amos N, Hughes C,. 2006. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther 8: R187.
3. Cha HJ, Park MT, Chung HY, et al. 1998. Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Oncogene 16: 771-778.
4. Christensen R, Bartels EM, Altman RD, Astrup A, Bliddal H,. 2008. Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 16: 965-972.
5. Chrubasik C, Duke RK, Chrubasik S,. 2006. The evidence for clinical efficacy of rose hip and seed: A systematic review. Phytother Res 20: 1-3.
6. Farahat MN, Yanni G, Poston R, Panayi GS,. 1993. Cytokine expression in synovial membranes of patients with rheumatoid-arthritis and osteoarthritis. Ann Rheum Dis 52: 870-875.
7. Goldring MB,. 2000. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2: 459-465.
8. Huang HC, Huang CY, Lin-Shiau SY, Lin JK,. 2009. Ursolic acid inhibits IL-1 beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression. Mol Carcinog 48: 517-531.
9. Jäger AK, Petersen KN, Thomasen G, Christensen SB,. 2008. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. Phytother Res 22: 982-984.
10. Larsen E, Kharazmi A, Christensen LP, Christensen SB,. 2003. An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 66: 994-995.
11. May MJ, Ghosh S,. 1998. Signal transduction through NF-kappa B. Immunol Today 19: 80-88.
12. Moesby L, Hansen EW, Christensen JD,. 1997. Pyrogen testing of lipid-based TPN using Mono Mac 6 monocyte cell line and DELFIA. J Clin Pharm Ther 22: 327-333.
13. Moesby L, Jensen S, Hansen EW, Christensen JD,. 1999. A comparative study of Mono Mac 6 cells, isolated mononuclear cells and Limulus amoebocyte lysate assay in pyrogen testing. Int J Pharm 191: 141-149.
14. Mosmann T,. 1983. Rapid colorimetric assay for cellular growth and survival-application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
15. Neustock P, Brand JM, Kruse A, Kirchner H,. 1993. Cytokine production of the human monocytic cell-line Mono Mac-6 in comparison to mature monocytes in peripheral-blood mononuclear-cells. Immunobiology 188: 293-302.
16. Pedersen MR, Hansen EW, Christensen JD,. 1994. Detection of lipopolysaccharide in the picogram range of tissue-culture media by a kinetic chromogenic limulus amebocyte lysate assay. J Clin Pharm Ther 19: 189-194.
17. Schwarz EM, Lu AP, Goater JJ, et al. 2000. Tumor necrosis factor-alpha/nuclear transcription factor-kappa B signaling in periprosthetic osteolysis. J Orthop Res 18: 472-480.
18. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB,. 2003. Ursolic acid inhibits nuclear factor-kappa B activation induced by carcinogenic agents through suppression of I kappa B alpha kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 63: 4375-4383.
19. Song CJ, Hsu K, Yamen E, et al. 2009. Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes. Atherosclerosis 207: 374-383.
20. Takada Y, Aggarwal BB,. 2003. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: Abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol 171: 3278-3286.
21. Wenzig EM, Widowitz U, Kunert O, et al. 2008. Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations. Phytomedicine 15: 826-835.
22. Wu MJ, Wang L, Ding HY, Weng CY, Yen JH,. 2004. Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappa B. J Biomed Sci 11: 186-199.
23. Yogeeswari P, Sriram D,. 2005. Betulinic acid and its derivatives: A review on their biological properties. Curr Med Chem 12: 657-666.
24. Ziegler-Heitbrock HWL, Thiel E, Futterer A, Herzog V, Wirtz A, Riethmuller G,. 1988. Establishment of a human cell-line (Mono Mac-6) with characteristics of mature monocytes. Int J Cancer 41: 456-461.