Significance of COX-2 and C/EBP β expression in hepatocellular carcinoma

World Chinese Journal of Digestology

Volumn 18, Issue 28, 2010, Pages 3040-3044

  Liang, Xi ^a   Hu, Ya Nan ^a   He, Shui Xiang ^a   Deng, Yuan ^a   Li, Xiao Feng ^a   Zhang, Ya Xin ^a   Hou, He Lei ^a   Zhu, Zhan Fang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

CCAAT enhancer binding protein ; Clinical pathological parameter; Cyclooxygenase 2; Hepatocellular carcinoma

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYCLOOXYGENASE 2;

ALCOHOL CONSUMPTION; ARTICLE; CANCER CLASSIFICATION; CANCER INVASION; CANCER SIZE; CANCER STAGING; CORRELATION ANALYSIS; DISTANT METASTASIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LYMPH NODE METASTASIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 79551649156     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: 10.11569/wcjd.v18.i27.3040     Document Type: Article

References (16)

1. Chi-Man Tang T, Tung-Ping Poon R, Fan ST. The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma. Biomed Pharmacother 2005; 59 Suppl 2: S311-S316
2. Kern MA, Schöneweiss MM, Sahi D, Bahlo M, Haugg AM, Kasper HU, Dienes HP, Käferstein H, Breuhahn K, Schirmacher P. Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice. Carcinogenesis 2004; 25: 1193-1199 (Pubitemid 38968047)
3. Liu W, Nakamura H, Tsujimura T, Cheng J, Yamamoto T, Iwamoto Y, Imanishi H, Shimomura S, Yamamoto T, Hirasawa T, Inagaki S, Nishiguchi S, Hada T. Chemoprevention of spontaneous development of hepatocellular carcinomas in fatty liver Shionogi mice by a cyclooxygenase-2 inhibitor. Cancer Sci 2006; 97: 768-773
4. Kern MA, Haugg AM, Eiteneuer E, Konze E, Drebber U, Dienes HP, Breuhahn K, Schirmacher P, Kasper HU. Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma. Liver Int 2006; 26: 604-612 (Pubitemid 43757123)
5. Yamanaka Y, Shiraki K, Inoue T, Miyashita K, Fuke H, Yamaguchi Y, Yamamoto N, Ito K, Sugimoto K, Nakano T. COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis. Int J Mol Med 2006; 18: 41-47
6. Bae SH, Jung ES, Park YM, Kim BS, Kim BK, Kim DG, Ryu WS. Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. Clin Cancer Res 2001; 7: 1410-1418
7. Kondo M, Yamamoto H, Nagano H, Okami J, Ito Y, Shimizu J, Eguchi H, Miyamoto A, Dono K, Umeshita K, Matsuura N, Wakasa K, Nakamori S, Sakon M, Monden M. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin Cancer Res 1999; 5: 4005-4012
8. Koga H, Sakisaka S, Ohishi M, Kawaguchi T, Taniguchi E, Sasatomi K, Harada M, Kusaba T, Tanaka M, Kimura R, Nakashima Y, Nakashima O, Kojiro M, Kurohiji T, Sata M. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 1999; 29: 688-696
9. Shiota G, Okubo M, Noumi T, Noguchi N, Oyama K, Takano Y, Yashima K, Kishimoto Y, Kawasaki H. Cyclooxygenase-2 expression in hepatocellular carcinoma. Hepatogastroenterology 1999; 46: 407-412
10. Qiu DK, Ma X, Peng YS, Chen XY. Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma. World J Gastroenterol 2002; 8: 815-817
11. Thomas B, Berenbaum F, Humbert L, Bian H, Béréziat G, Crofford L, Olivier JL. Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes. Eur J Biochem 2000; 267: 6798-6809
12. Isoda K, Koide H, Kojima M, Arita E, Ikkaku M, Higashiyama S, Tashiro F, Yamato E, Miyazaki J, Kawase M, Yagi K. Stimulation of hepatocyte survival and suppression of CCl4-induced liver injury by the adenovirally introduced C/EBPbeta gene. Biochem Biophys Res Commun 2005; 329: 182-187 (Pubitemid 40255438)
13. Casado M, Callejas NA, Rodrigo J, Zhao X, Dey SK, Boscá L, Martín-Sanz P. Contribution of cyclooxygenase 2 to liver regeneration after partial hepatectomy. FASEB J 2001; 15: 2016-2018