Synchrotron soft X-ray imaging and fluorescence microscopy reveal novel features of asbestos body morphology and composition in human lung tissues

Particle and Fibre Toxicology

Volumn 8, Issue , 2011, Pages

  Pascolo, Lorella ^a   Gianoncelli, Alessandra ^a   Kaulich, Burkhard ^a   Rizzardi, Clara ^b,c   Schneider, Manuela ^b   Bottin, Cristina ^b   Polentarutti, Maurizio ^a   Kiskinova, Maya ^a   Longoni, Antonio ^d   Melato, Mauro ^b,c,e  

^a SINCROTRONE TRIESTE   (Italy)

^b Hospital of Monfalcone   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

^d POLITECNICO DI MILANO   (Italy)

^e INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; IRON; MAGNESIUM; OXYGEN; SILICON; NANOPARTICLE;

ARTICLE; ASBESTOS BODY; ASBESTOSIS; CASE REPORT; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LUNG PARENCHYMA; MORPHOLOGY; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIOGRAPHY; SCANNING ELECTRON MICROSCOPY; SYNCHROTRON SOFT X RAY IMAGING; CHEMISTRY; LUNG; METHODOLOGY; PATHOLOGY; SPECTROMETRY; SYNCHROTRON; X RAY;

ASBESTOS; ASBESTOSIS; HUMANS; LUNG; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; SPECTROMETRY, X-RAY EMISSION; SYNCHROTRONS; X-RAYS;

EID: 79551633365     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-8-7     Document Type: Article

References (45)

1. Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009, 1:511-529. 10.1002/wnan.41, 2864601, 20049814.
2. Brims FJ. Asbestos--a legacy and a persistent problem. J R Nav Med Serv 2009, 95:4-11.
3. Bianchi C, Brollo A, Ramani L, Zuch C. Asbestos-related mesothelioma in Monfalcone, Italy. Am J Ind Med 1993, 24:149-160. 10.1002/ajim.4700240203, 8213843.
4. Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, . on behalf of the WHO International Agency for Research on Cancer Monograph Working Group A review of human carcinogens--Part C: metals, arsenic, dusts, and fibres. Lancet Oncol 2009, 10(5):453-454. 10.1016/S1470-2045(09)70134-2, 19418618, on behalf of the WHO International Agency for Research on Cancer Monograph Working Group.
5. Fubini B, Mollo L. Role of iron in the reactivity of mineral fibers. Toxicology Letters 1995, 82-83:951-960. 10.1016/0378-4274(95)03531-1, 8597167.
6. Kane A B. Asbestos bodies: clues to the mechanism of asbestos toxicity?. Human Pathology 2003, 34:735-736. 10.1016/S0046-8177(03)00420-9, 14506631.
7. Pezerat H, Guignard J, Cherrie JW. Man-made mineral fibers and lung cancer: an hypothesis. J Toxicol Ind Health 1992, 8:77-87.
8. Kamp DW. Asbestos-induced lung diseases: an update. Transl Res 2009, 153:143-152. 10.1016/j.trsl.2009.01.004, 19304273.
9. Lund LG, Williams MG, Dodson RF, Aust AE. Iron associated with asbestos bodies is responsible for the formation of single strand breaks in phi X174 RFI DNA. Occup Environ Med 1994, 51:200-204. 10.1136/oem.51.3.200, 1127940, 8130850.
10. Jaurand MC. Observations on the carcinogenicity of asbestos fibers. Ann N Y Acad Sci 1991, 643:258-270. 10.1111/j.1749-6632.1991.tb24470.x, 1809138.
11. Ghio AJ, Stonehuerner J, Richards J, Devlin RB. Iron homeostasis in the lung following asbestos exposure. Antioxid Redox Signal 2008, 10:371-377. 10.1089/ars.2007.1909, 17999626.
12. Hardy JA, Aust AE. The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks. Carcinogenesis 1995, 16:319-325. 10.1093/carcin/16.2.319, 7859364.
13. Borelli V, Brochetta C, Melato M, Rizzardi C, Polentarutti M, Busatto C, et al. A procedure for the isolation of asbestos bodies from lung tissue by exploiting their magnetic properties: a new approach to asbestos body study. J Toxicol Environ Health A 2007, 70:1232-1240. 10.1080/15287390701380906, 17573637.
14. Dodson RF, Hammar SP, Poye LW. A technical comparison of evaluating asbestos concentration by phase-contrast microscopy (PCM), scanning electron microscopy (SEM), and analytical transmission electron microscopy (ATEM) as illustrated from data generated from a case report. Inhal Toxicol 2008, 20:723-732. 10.1080/08958370701883250, 18464058.
15. Tuomi T. Fibrous minerals in the lungs of mesothelioma patients: comparison between data on SEM, TEM, and personal interview information. Am J Ind Med 1992, 21:155-162. 10.1002/ajim.4700210205, 1311147.
16. Dodson RF, Williams MG, O'Sullivan MF, Corn CJ, Greenberg SD, Hurst GA. A comparison of the ferruginous body and uncoated fiber content in the lungs of former asbestos workers. Am Rev Respir Dis 1985, 132:143-147.
17. Rinaudo C, Croce A, Musa M, Fornero E, Allegrina M, Trivero P, et al. Study of Inorganic Particles, Fibers, and Asbestos Bodies by Variable Pressure Scanning Electron Microscopy with Annexed Energy Dispersive Spectroscopy and Micro-Raman Spectroscopy in Thin Sections of Lung and Pleural Plaque. Appl Spectroscopy 2010, 6:571-577.
18. Nakamura E, Makishima A, Hagino K, Okabe K. Accumulation of radium in ferruginous protein bodies formed in lung tissue: association of resulting radiation hotspots with malignant mesothelioma and other malignancies. Proc Jpn Acad Ser B Phys Biol Sci 2009, 85:229-239. 10.2183/pjab.85.229, 19644223.
19. Shimizu Y, Dobashi K, Kusakbe T, Nagamine T, Oikawa M, Satoh T, et al. In-air micro-particle induced X-ray emission analysis of asbestos and metals in lung tissue. Int J Immunopathol Pharmacol 2008, 21:567-576.
20. Kaulich B, Thibault P, Gianoncelli A, Kiskinova M. Transmission and emission X-ray microscopy: operation modes, contrast mechanisms and applications. J Phys Condensed Matter
21. Kirz J, Jacobsen C, Howells M. Soft x-ray microscopes and their biological applications. 1995, 28:33-130.
22. Ide-Ektessabi A. Applications of Synchrotron Radiation: Microbeams in Cell Micro Biology and Medicine. 2007, Springer Verlag Berlin Heidelberg.
23. Fahrni CJ. Biological applications of X-ray fluorescence microscopy: exploring the subcellular topography and speciation of transition metals. Curr Opin Chem Biol 2007, 11:121-127. 10.1016/j.cbpa.2007.02.039, 17353139.
24. Kaulich B, Gianoncelli A, Beran A, Eichert D, Kreft I, Pongrac P, et al. Low-energy X-ray fluorescence microscopy opening new opportunities for bio-related research. J R Soc Interface 2009, 6(Suppl 5):S641-S647. 10.1098/rsif.2009.0157.focus, 2843971, 19570794.
25. Kaulich B, Susini J, David C, Di Fabrizio E, Morrison G, Charalambous P, et al. A European Twin X-ray Microscopy Station Commissioned at ELETTRA. Proceeding of 8th International Conference on X-ray micros, Conf Proc Series IPAP 2006, 7:22-25. Aoki S, Kagoshima Y, Suzuki Y.
26. Gianoncelli A, Morrison GR, Kaulich B, Bacescu D, Kovac J. A fast read-out CCD camera system for scanning X-ray microscopy. Appl Phys Lett 2006, 89:251117-251119.
27. Gianoncelli A, Kaulich B, Alberti R, Klatka T, Longoni A, de Marco A, et al. Simultaneous Soft X-ray Transmission and Emission Microscopy. Nuclear Instruments and Methods in Physics Research A 2009, 608:195-198.
28. Alberti R, Klatka T, Longoni A, Bacescu D, Marcello A, De Marco A, et al. Development of a low-energy x-ray fluorescence system with sub-micrometer spatial resolution. X-Ray Spectrometry 2009, 38:205-209.
29. Smith MJ, Naylor B. A method for extracting ferruginous bodies from sputum and pulmonary tissue. Am J Clin Pathol 1972, 58:250-254.
30. Sole A, Papillon E, Cotte M, Walter P, Susini J. A multiplatform code for the analysis of energy-dispersive X-ray fluorescence spectra. Spectrochim Acta B 2007, 62:63-68.
31. Ghio AJ, Churg A, Roggli VL. Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. Toxicol Pathol 2004, 32:643-649. 10.1080/01926230490885733, 15513907.
32. Ghio AJ, Roggli VL, Richards JH, Crissman KM, Stonehuerner JD, Piantadosi CA. Oxalate deposition on asbestos bodies. Hum Pathol 2003, 34:737-742. 10.1016/S0046-8177(03)00252-1, 14506632.
33. Ghio AJ, Funkhouser W, Pugh CB, Winters S, Stonehuerner JG, Mahar AM, et al. Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. Toxicol Pathol 2006, 34:723-729. 10.1080/01926230600932448, 17074740.
34. Seal S, Barr TL. Characterization of chemical interaction of asbestos surfaces during culturing with lung cells. J Vac Sci Technol A 1997, 15:1235-1245.
35. Yaman M. Comprehensive comparison of trace metal concentrations in cancerous and non-cancerous human tissues. Curr Med Chem 2006, 13:2513-2525. 10.2174/092986706778201620, 17017908.
36. Yaman M, Atici D, Bakirdere S, Akdeniz I. Comparison of trace metal concentrations in malign and benign human prostate. J Med Chem 2005, 48:630-634. 10.1021/jm0494568, 15658876.
37. Schroeder JA, Weingart C, Coras B, Hausser I, Reinhold S, Mack M, et al. Ultrastructural evidence of dermal gadolinium deposits in a patient with nephrogenic systemic fibrosis and end-stage renal disease. Clin J Am Soc Nephrol 2008, 3:968-975. 10.2215/CJN.00100108, 2440263, 18385397.
38. Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007, 458:48-56. 10.1016/j.abb.2006.03.031, 16712775.
39. Ullmer E, Borer H, Sandoz P, Mayr M, Dalquen P, Soler M. Diffuse pulmonary nodular infiltrates in a renal transplant recipient. Metastatic pulmonary calcification. Chest 2001, 120:1394-1398. 10.1378/chest.120.4.1394, 11591586.
40. Kowaltowski AJ, Naia-da-Silva ES, Castilho RF, Vercesi AE. Ca2+-stimulated mitochondrial reactive oxygen species generation and permeability transition are inhibited by dibucaine or Mg2+. Arch Biochem Biophys 1998, 359:77-81. 10.1006/abbi.1998.0870, 9799563.
41. Nielsen FH. Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 2010, 68:333-340. 10.1111/j.1753-4887.2010.00293.x, 20536778.
42. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008, 3:423-428. 10.1038/nnano.2008.111, 18654567.
43. Pacurari M, Castranova V, Vallyathan V. Single- and multi-wall carbon nanotubes versus asbestos: are the carbon nanotubes a new health risk to humans?. J Toxicol Environ Health A 2010, 73(5):378-395. 10.1080/15287390903486527, 20155580.
44. Donaldson K, Murphy F A, Duffin R, Poland C A. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 2010, 7:5. 10.1186/1743-8977-7-5, 2857820, 20307263.
45. Jaurand MC, Renier A, Daubriac J. Mesothelioma: Do asbestos and carbon nanotubes pose the same health risk?. Part Fibre Toxicol 2009, 6:16. 10.1186/1743-8977-6-16, 2706793, 19523217.