The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy

Indian Journal of Critical Care Medicine

Volumn 14, Issue 4, 2010, Pages 165-169

  Fuller, Brian M ^a   Gajera, Mithil ^b   Schorr, Christa ^b   Gerber, David ^b   Dellinger, R Phillip ^b   Parrillo, Joseph ^b   Zanotti, Sergio ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Anesthesiology   (United States)

Author keywords

Early goal directed therapy; packed red blood cell; septic shock; severe sepsis; transfusion

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; SEPTIC SHOCK; TREATMENT OUTCOME;

EID: 79551622907     PISSN: 09725229     EISSN: 1998359X     Source Type: Journal    
DOI: 10.4103/0972-5229.76078     Document Type: Article

References (16)

1. Consensus Conference (National Institutes of Health). Perioperative red blood cell transfusion. JAMA 1988;260:2700-3.
2. Gerber D. Transfusion of packed red blood cells in patients with ischemic heart disease. Crit Care Med 2008;36:1068-74.
3. Gould S, Cimino MJ, Gerber D. Packed Red Blood Cell Transfusion in the Intensive Care Unit: Limitations and Consequences. Am J Crit Care 2007;16:39-48.
4. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
5. Otero RM, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson KJ, et al. Early Goal-Directed Therapy in Severe Sepsis and Septic Shock Revisited: Concepts, Controversies, and Contemporary Findings. Chest 2006;130:1579-95.
6. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999;340:409-17.
7. Hebert PC, Tinmouth A, Corwin H. Controversies in RBC Transfusion in the Critically Ill. Chest 2007;131:1583-90.
8. Carson JL, Noveck H, Berlin JA, Gould SA. Mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion. Transfusion 2002;42:812-8.
9. Taylor RW, Manganaro L, O'Brien J, Trottier SJ, Parkar N, Veremakis C. Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient. Crit Care Med 2002;30: 2249-54.
10. Vamvakas EC, Carven JH. Allogeneic blood transfusion and postoperative duration of mechanical ventilation: effects of red cell supernatant, platelet supernatant, plasma components and total transfused fluid. Vox Sang 2002;82:141-9.
11. Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med 2005;33:1191-8.
12. Croce MA, Tolley EA, Coleridge JA, Fabian TC. Transfusions result in pulmonary morbidity and death after a moderate degree of injury. J Trauma 2005;59:19-23.
13. Yang X, Alexander KP, Chen AY, Roe MT, Brindis RG, Rao SV, et al. The implications of blood transfusions for patients with non- ST-segment elevation acute coronary syndromes: Results from the CRUSADE National Quality Improvement Initiative. J Am Coll Cardiol 2005;46:1490-5.
14. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 2003;54:898-905.
15. Palmieri TL, Caruso DM MD, Foster KN, Cairns BA, Peck MD, Gamelli RL, et al. Effect of blood transfusion on outcome after major burn injury: a multicenter study. Crit Care Med 2006;34:1602-7.
16. Fernandes CJ, Akamine N, De Marco F, De Souza J, Lagudis S, Knobel E. Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients. Crit Care Med 2001;5:362-7.