Comparison of pandemic (H1N1) 2009 and seasonal influenza viral loads, Singapore

Emerging Infectious Diseases

Volumn 17, Issue 2, 2011, Pages 287-291

  Lee, Chun K ^a   Lee, Hong K ^a   Loh, Tze P ^a   Lai, Florence Y L ^b   Tambyah, Paul A ^a,c   Chiu, Lily ^a   Koay, Evelyn S C ^a,c   Tang, Julian W ^a  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^b MINISTRY OF HEALTH   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

2009 H1N1 INFLUENZA; ADOLESCENT; ADULT; AGE; ARTICLE; CHILD; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; INFANT; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; SCHOOL CHILD; SEASONAL INFLUENZA; SINGAPORE; SYMPTOM; VIRUS LOAD;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; DISEASE OUTBREAKS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; MIDDLE AGED; PANDEMICS; RNA, VIRAL; SEASONS; SEVERITY OF ILLNESS INDEX; SINGAPORE; VIRAL LOAD; YOUNG ADULT;

EID: 79551618443     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid1702.100282     Document Type: Article

References (14)

1. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team; Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;360:2605-15. DOI: 10.1056/NEJMoa0903810
2. Tang JW, Tambyah PA, Lai FY, Lee HK, Lee CK, Loh TP, et al. Differing symptom patterns in early pandemic vs seasonal influenza infections. Arch Intern Med. 2010;170:861-7. DOI: 10.1001/archinternmed.2010.108
3. To KK, Chan KH, Li IW, Tsang TY, Tse H, Chan JF, et al. Viral load in patients infected with pandemic H1N1 2009 influenza A virus. J Med Virol. 2010;82:1-7. DOI: 10.1002/jmv.21664
4. Peiris JS, Cheung CY, Leung CY, Nicholls JM. Innate immune responses to influenza A H5N1: friend or foe? Trends Immunol. 2009;30:574-84. DOI: 10.1016/j.it.2009.09.004
5. Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, Ebihara H, et al. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 2007;445:319-23. DOI:10.1038/nature05495
6. Lee HK, Lee CK, Loh TP, Tang JW, Chiu L, Tambyah PA, et al. Diagnostic testing for pandemic influenza in Singapore: a novel dual-gene quantitative real-time RT-PCR for the detection of influenza A/H1N1/2009. J Mol Diagn. 2010;12:636-43. DOI: 10.2353/jmoldx.2010.100010
7. Bridges CB, Kuehnert MJ, Hall CB. Transmission of influenza: implications for control in health care settings. Clin Infect Dis. 2003;37:1094-101. DOI: 10.1086/378292
8. Hancock K, Veguilla V, Lu X, Zhong W, Butler EN, Sun H, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 2009;361:1945-52. DOI: 10.1056/ NEJMoa0906453
9. Chen H, Wang Y, Liu W, Zhang J, Dong B, Fan X, et al. Serologic survey of pandemic (H1N1) 2009 virus, Guanxi Province, China. Emerg Infect Dis. 2009;15:1849-50.
10. Tang JW, Tambyah PA, Wilder-Smith A, Puong KY, Shaw R, Barr IG, et al. Cross-reactive antibodies to pandemic (H1N1) 2009 virus, Singapore. Emerg Infect Dis. 2010;16:874-6.
11. Woo PC, Tung ET, Chan KH, Lau CC, Lau SK, Yuen KY. Cytokine profiles induced by the novel swine-origin influenza A/H1N1 virus: implications for treatment strategies. J Infect Dis. 2010;201:346-53. DOI: 10.1086/649785
12. Bermejo-Martin JF, Ortiz de Lejarazu R, Pumarola T, Rello J, Almansa R, Ramirez P, et al. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Crit Care. 2009;13:R201. DOI: 10.1186/cc8208
13. Bermejo-Martin JF, Martin-Loeches I, Rello J, Antón A, Almansa R, Xu L, et al. Host adaptive immunity deficiency in severe pandemic influenza. Crit Care. 2010;14:R167. DOI: 10.1186/cc9259
14. Gill JR, Sheng Z-M, Ely SF, Guinee DG, Beasley MB, Suh J, et al. Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections. Arch Pathol Lab Med. 2010;134:235-43.