Involvement of E2F1 transcriptional activity in cadmium-induced cell-cycle arrest at G1 in human lung fibroblasts

Environmental and Molecular Mutagenesis

Volumn 52, Issue 2, 2011, Pages 145-152

  Choi, You Jin ^a   Yin, Hu Quan ^a   Suh, Hyo Ryung ^a   Lee, Young Ju ^a   Park, So Ra ^a   Lee, Byung Hoon ^a  

^a Seoul National University   (South Korea)

Author keywords

Cadmium; E2F1; G1 phase arrest; Retinoblastoma protein; WI38 human lung fibroblast

Indexed keywords

CADMIUM; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DEATH; CELL GROWTH; COMPLEX FORMATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PROTEIN PHOSPHORYLATION; STATISTICAL SIGNIFICANCE; TRANSCRIPTION REGULATION;

CADMIUM; CELL LINE; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; E2F1 TRANSCRIPTION FACTOR; FIBROBLASTS; G1 PHASE; HUMANS; LUNG; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79551602229     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20593     Document Type: Article

References (32)

1. Ahn JD, Kim CH, Magae J, Kim YH, Kim HJ, Park KK, Hong S, Park KG, Lee IK, Chang YC. 2003. E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. Biochem Biophys Res Commun 310: 1048-1053.
2. Akiyama T, Sugiyama K, Shimizu M, Tamaoki T, Akinaga S. 1999. G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation. Jpn J Cancer Res 90: 1364-1372.
3. Arroyo M, Raychaudhuri P. 1992. Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein. Nucleic Acids Res 20: 5947-5954.
4. Bakshi S, Zhang X, Godoy-Tundidor S, Cheng RY, Sartor MA, Medvedovic M, Ho SM. 2008. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. Environ Health Perspect 116: 769-776.
5. Beyersmann D, Hartwig A. 2008. Carcinogenic metal compounds: Recent insight into molecular and cellular mechanisms. Arch Toxicol 82: 493-512.
6. Biagioli M, Wätjen W, Beyersmann D, Zoncu R, Cappellini C, Ragghianti M, Cremisi F, Bucci S. 2001. Cadmium-induced apoptosis in murine fibroblasts is suppressed by Bcl-2. Arch Toxicol 75: 313-320.
7. Chao JI, Yang JL. 2001. Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem Res Toxicol 14: 1193-1202.
8. Chatterjee S, Kundu S, Sengupta S, Bhattacharyya A. 2009. Divergence to apoptosis from ROS induced cell cycle arrest: Effect of cadmium. Mutat Res 663: 22-31
9. Dyson N. 1998. The regulation of E2F by pRB-family proteins. Gene Dev 12: 2245-2262.
10. Ginsberg D. 2002. E2F1 pathways to apoptosis. FEBS Lett 529: 122-125.
11. Hader C, Hadnagy W, Seemayer NH. 1996. A rapid method for detection of nongenotoxic carcinogens of environmental pollutants using synchronized V79 cells and flow cytometry. Toxicol Lett 88: 99-108.
12. Hahm ER, Singh SV. 2007. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity. Mol Cancer Ther 6: 2686-2695.
13. Hauck L, von Harsdorf R. 2005. E2F transcription factors and pRb pocket proteins in cell cycle progression. Methods Mol Biol 296: 239-245.
14. Johnson PF. 2005. Molecular stop signs: Regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 118: 2545-2555.
15. Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7: 331-342.
16. Kim J, Kim SH, Johnson VJ, Sharma RP. 2005. Extracellular signal-regulated kinase-signaling-dependent G2/M arrest and cell death in murine macrophages by cadmium. Environ Toxicol Chem 24: 3069-3077.
17. Lee KW, Kim HJ, Lee YS, Park HJ, Choi JW, Ha J, Lee KT. 2007. Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte. Carcinogenesis 28: 1928-1936.
18. Lee MH, Yang HY. 2001. Negative regulators of cyclin-dependent kinases and their roles in cancers. Cell Mol Life Sci 58: 1907-1922.
19. Li GY, Kim M, Kim JH, Lee MO, Chung JH, Lee BH. 2008. Gene expression profiling in human lung fibroblast following cadmium exposure. Food Chem Toxicol 46: 1131-1137.
20. Liu Q, Hilsenbeck S, Gazitt Y. 2003. Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL. Blood 101: 4078-4087.
21. Liu ZM, Chen GG, Ng EK, Leung WK, Sung JJ, Chung SC. 2004. Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells. Oncogene 23: 503-513.
22. Murillo G, Salti GI, Kosmeder JWII, Pezzuto JM, Mehta RG. 2002. Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer 38: 2446-2454.
23. Murphree AL, Benedict WF. 1984. Retinoblastoma: Clues to human oncogenesis. Science 223: 1028-1033.
24. Nohara K, Ao K, Miyamoto Y, Suzuki T, Imaizumi S, Tateishi Y, Omura S, Tohyama C, Kobayashi T. 2008. Arsenite-induced thymus atrophy is mediated by cell cycle arrest: A characteristic downregulation of E2F-related genes revealed by a microarray approach. Toxicol Sci 101: 226-238.
25. Ponce RA, Kavanagh TJ, Mottet NK, Whittaker SG, Faustman EM. 1994. Effects of methyl mercury on the cell cycle of primary rat CNS cells in vitro. Toxicol Appl Pharmacol 127: 83-90.
26. Powlin SS, Keng PC, Miller RK. 1997. Toxicity of cadmium in human trophoblast cells (JAr choriocarcinoma): Role of calmodulin and the calmodulin inhibitor, zaldaride maleate. Toxicol Appl Pharmacol 144: 225-234.
27. Puga A, Barnes SJ, Dalton TP, Chang C, Knudsen ES, Maier MA. 2000. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem 275: 2943-2950.
28. Sherr CJ. 1996. Cancer cell cycles. Science 274: 1672-1677.
29. Waalkes MP. 2003. Cadmium carcinogenesis. Mutat Res 533: 107-120.
30. Xie J, Shaikh ZA. 2006. Cadmium induces cell cycle arrest in rat kidney epithelial cells in G2/M phase. Toxicology 224: 56-65.
31. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704.
32. Yang PM, Chiu SJ, Lin KA, Lin LY. 2004. Effect of cadmium on cell cycle progression in Chinese hamster ovary cells. Chem Biol Interact 149: 125-136.