High α-defensin and S100A7 expression and missing DOC-1 down-regulation characterize irritation fibromas of the oral cavity and may counteract malignant transformation

Journal of Craniofacial Surgery

Volumn 22, Issue 1, 2011, Pages 100-104

  Winter, Jochen ^a   Pantelis, Annette ^a   Allam, Jean Pierre ^a   Novak, Natalija ^a   Reich, Rudolf ^a   Martini, Markus ^a   Bergé, Stefaan ^b   Deschner, James ^a   Jepsen, Soeren ^a   Wenghoefer, Matthias ^a  

^a UNIVERSITY OF BONN   (Germany)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Defensins; DOC 1; interleukin; irritation fibroma; matrix metalloproteases; S100A7

Indexed keywords

ALPHA DEFENSIN; DEFENSIN 1; DEFENSIN 3; DOC 1R PROTEIN, HUMAN; DOC-1R PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN S 100; S100A7 PROTEIN, HUMAN; STROMELYSIN; TUMOR MARKER;

ARTICLE; BIOPSY; CELL TRANSFORMATION; DOWN REGULATION; ENZYME IMMUNOASSAY; FIBROMA; GENE EXPRESSION REGULATION; GENETICS; GINGIVA TUMOR; HUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

ALPHA-DEFENSINS; BIOPSY; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; FIBROMA; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GINGIVAL NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; MATRIX METALLOPROTEINASE 3; ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S100 PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 79551598557     PISSN: 10492275     EISSN: None     Source Type: Journal    
DOI: 10.1097/SCS.0b013e3181f6c5e9     Document Type: Article

References (25)

1. Bouquot JE, Gorlin RJ. Leukoplakia, lichen planus and other oral keratoses in 23,616 white Americans over the age of 35 years. Oral Surg 1986;61:373-381
2. Bouquot JE, Gundlach KKH. Oral exophytic lesions in 23,616 white Americans over 35 years of age. Oral Surg Oral Med Oral Pathol 1986;62:284-291
3. Dayan D, Bodner L, Hammel I, et al. Histochemical characterization of collagen fibers in fibrous overgrowth (irritation fibroma) of the oral mucosa: Effect of age and duration of lesion. Arch Gerontol Geriatr 1994;18:53-57
4. Kim ST, Kim HJ, Park IS, et al. Chronic, reactive conditions of the oral cavity simulating mucosal carcinomas: CTandMR imaging findings with pathologic correlation in five patients. Clin Imaging 2005;29:406-411
5. Wenghoefer M, Pantelis A, Dommisch H, et al. Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. Int J Oral Maxillofac Surg 2008;37:660-663
6. Dommisch H, Steglich M, Eberhard J, et al. Phosphatidylinositol-3-kinase inhibitor LY 294002 blocks Streptococcus mutansYinduced interleukin (IL)-6 and IL-8 gene expression in odontoblast-like cells. Int Endod J 2008;41:763-771
7. Hieshima K, Imai T, Opdenakker G, et al. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem 1997;272:5846-5853
8. Takahashi K, Nakanishi T, Yumoto H, et al. CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines. Oral Microbiol Immunol 2008;23:320
9. Zhang S, Du Y, Tao J, et al. Expression of cytosolic phospholipase A2 and cyclooxygenase 2 and their significance in human oral mucosae, dysplasias and squamous cell carcinomas. ORL J Otorhinolaryngol Relat Spec 2008;70:242-248
10. Dommisch H, Acil Y, Dunsche A, et al. Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases. Oral Microbiol Immunol 2005;20:186-190
11. Froy O. Regulation of mammalian defensin expression by Toll-like receptorYdependent and independent signalling pathways [Review]. Cell Microbiol 2005;7:1387-1397
12. Lehrer RI, Lichtenstein AK, Ganz T. Defensins: Antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 1993; 11:105-128
13. Watson PH, Leygue ER, Murphy LC. Psoriasin (S100A7). Int J Biochem Cell Biol 1998;30:567-571
14. Murphy G, Nagase H. Progress in matrix metalloproteinase research. Mol Aspects Med 2008;29:290-308
15. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem 1999;274:21491-21494
16. Peng H, Shintani S, Kim Y, et al. Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-betaYSmad signaling pathway. Neoplasia 2006;8:1028-1036
17. Shintani S, Mihara M, Terakado N, et al. Reduction of p12DOC-1 expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Clin Cancer Res 2001;7:2776-2782
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:2002-2007
19. Leygue E, Snell L, Hiller T, et al. Differential expression of psoriasin messenger RNA between in situ and invasive human breast carcinoma. Cancer Res 1996;56:4606-4609
20. Higazzi AA, Nassar T, Ganz T, et al. The alpha-defensins stimulate proteoglycan-dependent catabolism of low density lipoprotein by vascular cells: A new class of inflammatory apolipoprotein and a possible contributor to atherogenesis. Blood 2000;96:1393-1398
21. Murphy CJ, Foster BA, Mannis MJ, et al. Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol 1993;155:408-413
22. Müller CA, Markovic-Lipkovski J, Klatt T, et al. Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: Influences on tumor cell proliferation. Am J Pathol 2002;160:1311-1324
23. Blons H, Gad S, Zinzindohoué F, et al. Matrix metalloproteinase 3 polymorphism: A predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma. Clin Cancer Res 2004;10:2594-2599
24. Ye H, Yu T, Temam S, et al. Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics 2008;9:69
25. Kim SG, Kim MH, Chae CH, et al. Downregulation of matrix metalloproteinases in hyperplastic dental follicles results in abnormal tooth eruption. BMB Rep 2008;41:322-327