Inhibition of the isoprenoid biosynthesis pathway; Detection of intermediates by UPLC-MS/MS

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1811, Issue 4, 2011, Pages 227-233

  Henneman, Linda ^a   Van Cruchten, Arno G ^a   Kulik, Willem ^a   Waterham, Hans R ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Farnesyl pyrophosphate; Geranylgeranyl pyrophosphate; Isoprenoid biosynthesis; Mass spectrometry; Mevalonate pathway

Indexed keywords

5 PYROPHOSPHOMEVALONATE; 6 FLUOROMEVALONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; DIMETHYLALLYLPYROPHOSPHATE; FARNESYL DIPHOSPHATE; FARNESYL PYROPHOSPHATE SYNTHASE; GERANYL PYROPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYACID; ISOPENTENYL DIPHOSPHATE; ISOPRENOID; MEVALONIC ACID; NITROGEN; PAMIDRONIC ACID; SYNTHETASE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG; ZARAGOZIC ACID A; ZOLEDRONIC ACID;

ARTICLE; BIOSYNTHESIS; CELL STRAIN HEPG2; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; INCUBATION TIME; LYMPHOBLAST; MASS SPECTROMETRY; PRIORITY JOURNAL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ALKYL AND ARYL TRANSFERASES; BICYCLO COMPOUNDS, HETEROCYCLIC; BONE DENSITY CONSERVATION AGENTS; CHROMATOGRAPHY, LIQUID; DIPHOSPHONATES; ENZYME INHIBITORS; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; FARNESYLTRANSTRANSFERASE; FIBROBLASTS; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMIDAZOLES; LYMPHOCYTES; MEVALONIC ACID; PRENYLATION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TERPENES; TRICARBOXYLIC ACIDS;

EID: 79551589438     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.01.002     Document Type: Article

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