Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6

Burns

Volumn 37, Issue 2, 2011, Pages 222-226

  Beffa, David C ^a   Fischman, Alan J ^a   Fagan, Shawn P ^a   Hamrahi, Victoria F ^a   Paul, Kasie W ^a   Kaneki, Masao ^a   Yu, Yong Ming ^a   Tompkins, Ronald G ^a   Carter, Edward A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Burn; Cecal ligation; Interleukin 6 (IL 6); Sepsis; Simvastatin; Survival

Indexed keywords

INTERLEUKIN 6; KETAMINE; PLACEBO; SIMVASTATIN; XYLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BURN INFECTION; CECUM; CONTROLLED STUDY; DOSE RESPONSE; LIGATION; MALE; MORTALITY; MOUSE; NONHUMAN; SCALD; SEPSIS; SURVIVAL;

ANIMALS; BURNS; DISEASE MODELS, ANIMAL; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-6; MALE; MICE; SEPSIS; SIMVASTATIN; SURVIVAL ANALYSIS;

EID: 79551580130     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.burns.2010.10.010     Document Type: Article

References (22)

1. G.S. Martin, D.M. Mannino, S. Eaton, and M. Moss The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 2003 1546 1554
2. R.S. Hotchkiss, and I.E. Karl The pathophysiology and treatment of sepsis N Engl J Med 348 2 2003 138 150
3. B.A. Pruitt Jr. Infection and the burn patient Br J Surg 77 1990 1081
4. S.T. O'Sullivan, and T.P.F. O'Conner Immunosuppression following thermal injury: the pathogenesis of immunocysfunction Br J Plastic Surg 50 1997 615 623
5. M.G. Schwacha, C.P. Schneider, and I.H. Chaudry Differential expression and tissue compartmentalization of the inflammatory responses following thermal injury Cytokine 17 2002 266 274
6. E.M. Mortensen, M.I. Restrepo, A. Anzueto, and J. Pugh The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia Respir Res 6 2005 82
7. P. Kruger, K. Fitzsimmons, D. Cook, M. Jones, and G. Nimmo Statin therapy is associated with fewer deaths in patients with bacteraemia Intensive Care Med 32 1 2006 75 79
8. Y. Almog, A. Shefer, V. Novack, N. Maimon, L. Barski, and M. Eizinger Prior statin therapy is associated with a decreased rate of severe sepsis Circulation 110 7 2004 880 885
9. Y. Almog, V. Novack, M. Eisinger, A. Porath, L. Novack, and H. Gilutz The effect of statin therapy on infection-related mortality in patients with atherosclerotic diseases Crit Care Med 35 2 2007 372 378
10. D.G. Hackam, M. Mamdani, P. Li, and D.A. Redelmeier Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis Lancet 367 9508 2006 413 418
11. P.P. Dobesh, D.G. Klepser, T.R. McGuire, C.W. Morgan, and K.M. Olsen Reduction in mortality associated with statin therapy in patients with severe sepsis Pharmacotherapy 29 2009 621 630
12. T.M. Pawley, E.A. Carter, B.P. Bode, A. Hirschman, and R.A.G. Tompkins Central role of interleukin-6 in burned induced stimulation of hepatic amino acid transport Int J Mol Med 12 2003 541 554
13. M.W. Merx, E.A. Liehn, U. Janssens, R. Lutticken, J. Schrader, and P. Hanrath HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis Circulation 109 21 2004 2560 2565
14. D. Rittirsch, M.S. Huber-Lang, M.A. Flier, and P.A. Ward Immunodesign of experimental sepsis by cecal ligation and puncture Nat Protocol 4 1 2009 31 36
15. S. Arbabi, I. Garcia, G.J. Bauer, and R. Maier Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway J Immunol 162 1999 7441 7445
16. O. Shelley, T. Murphay, H. Paterson, J. Mannick, and J. Lederer Interaction between the innate and adaptive immune systems is required to survive sepsis and control inflammation after injury Shock 20 2003 123 129
17. M.J. Garcia, R.F. Reinoso, A.S. Navarrok, and J.R. Prous Clincal pharmacokinetics of statins Methods Find Exp Clin Pharmacol 25 2003 457 460
18. E.A. Carter, R.A. Hatz, W.A. Walker, and R.G. Tompkins Injury-induced inhibition of small intestinal protein and nucleic acid synthesis Gastroenterology 98 1990 1445 1451
19. B. Schluter, B. Konig, U. Bergmann, F.E. Muller, and W. Kong Interleukin 6 - a potential marker of lethal sepsis after major thermal injury: evidence for increased IL-6 production by peripheral blood mononuclear cells J Trauma 31 1991 1663 1670
20. F. Montecucco, and F. Mach Update on statin-meidated anti-inflammatory activities in atherosclerosis Semin Immunopathol 31 2009 127 142
21. D.G. Remick, G. Bolgos, S. Copeland, and J. Siddiqui Role of interleukin-6 in mortality from and physiologica response to sepsis Infect Immun 73 2005 2751 2757
22. M.D. Fogerty, D. Efron, A. Morandi, J. Guy, N. Abumrad, and A. Barbul The effect of preinjury statin use on mortality and septic shock in elderly burn patients J Trauma 69 1 2010 99 103