Genotoxicity detection of five medicinal plants in Nigeria

Journal of Toxicological Sciences

Volumn 36, Issue 1, 2011, Pages 87-93

  Hong, Chang Eui ^a   Lyu, Su Yun ^b  

^a Yeungnam University   (South Korea)

^b Daegu Haany University   (South Korea)

Author keywords

Alchornea cordifolia; Bacterial reverse mutation test; Cnestis ferruginea; Lonchocarpus sericeus; Senna alata; Trema orientalis

Indexed keywords

ALCHORNEA CORDIFOLIA EXTRACT; CNESTIS FERRUGINEA EXTRACT; LONCHOCARPUS SERICEUS EXTRACT; PLANT EXTRACT; SENNA ALATA EXTRACT; TREMA ORIENTALIS EXTRACT; UNCLASSIFIED DRUG;

ADDITION REACTION; AFRICA; ALCHORNEA CORDIFOLIA; AMES TEST; ANIMAL CELL; ARTICLE; BACTERIAL MUTATION; CNESTIS FERRUGINEA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG SAFETY; ESCHERICHIA COLI; GENOTOXICITY; IN VITRO STUDY; INFLAMMATORY DISEASE; LONCHOCARPUS SERICEUS; MEDICINAL PLANT; MUTAGEN TESTING; MUTATIONAL ANALYSIS; NIGERIA; NONHUMAN; REVERTANT; SALMONELLA TYPHIMURIUM; SENNA ALATA; TRADITIONAL MEDICINE; TREMA ORIENTALIS;

ALCHORNEA CORDIFOLIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LONCHOCARPUS SERICEUS; SALMONELLA TYPHIMURIUM; SENNA ALATA; TREMA ORIENTALIS;

EID: 79551579369     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.36.87     Document Type: Article

References (24)

1. Adewunmi, C.O., Agbedahunsi, J.M., Adebajo, A.C., Aladesanmi, A.J., Murphy, N. and Wando, J. (2001): Ethno-veterinary medicine: screening of Nigerian medicinal plants for trypanocidal properties. J. Ethnopharmacol., 77, 19-24.
2. Akintonwa, A., Awodele, O., Afolayan, G. and Coker, H.A. (2009): Mutagenic screening of some commonly used medicinal plants in Nigeria. J. Ethnopharmacol., 125, 461-470.
3. Alencar, N.M., Cavalcante, C.F., Vasconcelos, M.P., Leite, K.B., Aragao, K.S., Assreuy, A.M., Nogueira, N.A., Cavada, B.S. and Vale, M.R. (2005): Anti-inflammatory and antimicrobial effect of lectin from Lonchocarpus sericeus seeds in an experimental rat model of infectious peritonitis. J. Pharm. Pharmacol., 57, 919-922.
4. Ames, B.N., Durston, W.E., Yamasaki, E. and Lee, F.D. (1973): Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. USA, 70, 2281-2285.
5. Ames, B.N., McCann, J. and Yamasaki, E. (1975): Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res., 31, 347-364.
6. Aschfalk, A., Steingass, H., Müller, W. and Drochner, W. (2000): Acceptance and digestibility of some selected browse feeds with varying tannin content as supplements in sheep nutrition in West Africa. J. Vet. Med. A Physiol. Pathol. Clin. Med., A47, 523-524.
7. Atere, T.G. and Ajao, A.T. (2009): Toxicological implications of crude alkaloidal fraction from Cnestis ferruginea D.C. root on liver function indices of male Wistar rats. IJBHS, 5, 145-155.
8. Dimo, T., Ngueguim, F.T., Kamtchouing, P., Dongo, E. and Tan, PV. (2006): Glucose lowering efficacy of the aqueous stem bark extract of Trema orientalis (Linn) Blume in normal and streptozotocin diabetic rats. Pharmazie, 61, 233-236.
9. Garon, D., Chosson, E., Rioult, J.-P., Eldin de Pecoulas, P., Brasseur, P. and Vérité, P. (2007): Poisoning by Cnestis ferruginea in Casamance (Senegal): An etiological approach. Toxicon, 50, 189-195.
10. Gehlot, D. and Bohra, A. (2000): Toxic effect of various plant part extracts on the causal organism of typhoid fever. Cur. Sci., 78, 780-781.
11. Girón, L.M., Freire, V., Alonzo, A. and Cáceres, A. (1991): Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala. J. Ethnopharmacol., 34, 173-187.
12. Gomes-Carneiro, M.R., Viana, M.E.S., Felzenszwalb, I. and Paumgartten, F.J.R. (2005): Evaluation of β-myrcene, α-terpinene and (+)- and (-)-α-pinene with the Salmonella/microsome assay. Food Chem. Toxicol., 43, 247-252.
13. Hennebelle, T., Weniger, B., Joseph, H., Sahpaz, S. and Bailleul, F. (2009): Senna alata. Fitoterapia, 80, 385-393.
14. Longuefosse, J.-L. andNossin, E. (1996): Medical ethnobotany survey in Martinique. J. Ethnopharmacol., 53, 117-142.
15. Magassouba, F.B., Diallo, A., Kouyaté, M., Mara, F., Mara, O., Bangoura, O., Camara, A., Traoré, S., Diallo, A.K., Zaoro, M., Lamah, K., Diallo, S., Camara, G, Traoré, S., Kéita, A., Camara, M.K., Barry, R., Kéita, S., Oularé, K., Barry, M.S., Donzo, M., Camara, K., Toté, K., Berghe, D.V., Totté, J., Pieters, L., Vlietinck, A.J. and Balde, A.M. (2007): Ethnobotanical survey and antibacterial activity of some plants used in Guinean traditional medicine. J. Ethnopharmacol., 114, 44-53.
16. Maron, D.M. and Ames, B.N. (1983): Revised methods for the Salmonella mutagenicity test. Mutat. Res., 113, 173-215.
17. Ogungbamila, F.O. and Samuelsson, G. (1999): Smooth muscle relaxing flavonoids from Alchornea cordifolia. Acta Pharm. Nord., 2, 421-422.
18. Okwu, D.E. and Iroabuchi, F. (2004): Phytochemical analysis and antimicrobial activity screening of aqueous and ethanolic root extracts of Uvaria chamae Beuv and Cnestis ferruginea D. C. J. Chem. Soc. Nigeria, 29, 112-114.
19. Olugbade, T.A., Oluwadiya, J.O. and Yisak, W.A. (1982): Chemical constituents of Cnestis ferruginea DC. I. Petroleum ether fraction. J. Ethnopharmacol., 6, 365-370.
20. Pesewu, G.A., Cutler, R.R. and Humber, D.P. (2008): Antibacterial activity of plants used in traditional medicines of Ghana with particular reference to MRSA. J. Ethnopharmacol., 116, 102-111.
21. Saad, B., Azaizeh, H., Abu-Hijleh, G. and Said, O. (2006): Safety of Traditional Arab Herbal Medicine. Evid. Based Complement Alternat. Med., 3, 433-439.
22. Sodipo, O.A., Effraim, K.D. and Emmagun, E. (1998): Effect of aqueous leaf extract of Cassia alata (Linn.) on some haematological indices in albino rats. Phytother. Res., 12, 431-433.
23. Tona, L., Kambu, K., Ngimbi, T., Mesia, K., Penge, O., Lusakibanza, M., Cimanga, K., De Bryne, T., Apers, S., Totte, J., Pieters, L. and Vlietinck, A.J. (2000): Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa Congo. Phytomedicine, 7, 31-38.
24. Yagi, S.M., El Tigani, S. and Adam, S.E.I. (1998): Toxicity of Senna obtusifolia fresh and fermented leaves (kawal), Senna alata leaves and some products from Senna alata on rats. Phytother. Res., 12, 324-330.