MALDI imaging as a specific diagnostic tool for routine cervical cytology specimens

International Journal of Molecular Medicine

Volumn 27, Issue 3, 2011, Pages 417-421

  Schwamborn, Kristina ^a   Krieg, René C ^a   Uhlig, Sandra ^a   Ikenberg, Hans ^b   Wellmann, Axel ^c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b CytoMol   (Germany)

^c Institute of Pathology   (Germany)

Author keywords

Cervical cytology; Diagnostics; Human papilloma virus; Matrix assisted laser desorption ionization imaging; Pathology; Proteomics; Screening

Indexed keywords

VIRUS DNA;

ARTICLE; CANCER GRADING; CANCER INVASION; CLINICAL ARTICLE; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; HUMAN TISSUE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PAPANICOLAOU TEST; PATIENT CODING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY; VIRUS DETECTION; WART VIRUS;

ALPHAPAPILLOMAVIRUS; CARCINOMA, SQUAMOUS CELL; CERVIX UTERI; DIAGNOSTIC IMAGING; FEMALE; HUMANS; NEOPLASM INVASIVENESS; PAPILLOMAVIRUS INFECTIONS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 79551575580     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2010.587     Document Type: Article

References (24)

1. Guidozzi F: Screening for cervical cancer. Obstet Gynecol Surv 4: 247-252, 1996.
2. Birley HD: Human papillomaviruses, cervical cancer and the developing world. Ann Trop Med Parasitol 5: 453-463, 1995.
3. Tkeshelashvili VT, Bokhman JV, Kuznetzov VV, Maximov SJ and Chkuaseli GT: Geographic peculiarities of endometrial and cervical cancer incidence in five continents (Review). Eur J Gynaecol Oncol 2: 89-94, 1993.
4. DeMay RM: Cytopathology of false negatives preceding cervical carcinoma. Am J Obstet Gynecol 175: 1110-1113, 1996.
5. Wright TC, Kurman RJ and Ferenczy A: Precancerous lesions of the cervix. In: Blaustein's Pathology of the Female Genital Tract. 4th edition. Kurman RJ (ed). Springer-Verlag, New York, pp229-232, 1994.
6. Wright TC, Sun XW and Koulos J: Comparison of management algorithms for the evaluation of women with low-grade cytologic abnormalities. Obstet Gynecol 2: 202-210, 1995.
7. Hatch KD, Schneider A and Abdel-Nour MW: An evaluation of human papillomavirus testing for intermediate- and high-risk types as triage before colposcopy. Am J Obstet Gynecol 172: 1150-1155, 1995.
8. zur Hausen H: Papillomavirus infections - a major cause of human cancers. Biochim Biophys Acta 1288: F55-F78, 1996.
9. zur Hausen H: Papillomaviruses in human cancers. Proc Assoc Am Physicians 111: 581-587, 1999.
10. Wolf JK and Ramirez PT: The molecular biology of cervical cancer. Cancer Invest 19: 621-629, 2001.
11. Solomon D, Schiffman M, Tarone R and the ALTS study group: Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst 93: 293-299, 2001. (Pubitemid 32219816)
12. Lesnikova I, Lidang M, Hamilton-Dutoit S and Koch J: p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens. Diagn Pathol 4: 22, 2009.
13. Wentzensen N and Klug SJ: Early detection of cervical carcinomas: finding an overall approach. Dtsch Arztebl Int 37: 617-622, 2008.
14. Celis JE and Gromov P: Proteomics in translational cancer research: toward an integrated approach. Cancer Cell 3: 9-15, 2003.
15. Hanash S: Disease proteomics. Nature 422: 226-232, 2003.
16. Chaurand P, Sanders ME, Jensen RA and Caprioli RM: Proteomics in diagnostic pathology. Am J Pathol 165: 1057-1068, 2004.
17. Chaurand P, Stoeckli M and Caprioli RM: Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry. Anal Chem 71: 5263-5270, 1999.
18. Stoeckli M, Chaurand P, Hallahan DE and Caprioli RM: Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat Med 7: 493-496, 2001.
19. Caldwell RL and Caprioli RM: Tissue profiling by mass spectrometry. Mol Cell Proteomics 4: 394-401, 2005.
20. Seeley EH and Caprioli RM: Special feature: molecular imaging of proteins in tissues by mass spectrometry. Proc Natl Acad Sci USA 47: 18126-18131, 2008.
21. Bauer JA, Chakravarthy AB, Rosenbluth JM, Mi D, Seeley EH, De Matos Granja-Ingram N, Olivares MG, Kelley MC, Mayer IA, Meszoely IM, Means-Powell JA, Johnson KN, Tsai CJ, Ayers GD, Sanders ME, Schneider RJ, Formenti SC, Caprioli RM and Pietenpol JA: Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Clin Cancer Res 2: 681-690, 2010.
22. Albrethsen J, Bogebo R, Gammeltoft S, Olsen J, Winther B and Raskov H: Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study. BMC Cancer 5: 8, 2005.
23. Roesch-Ely M, Nees M, Karsai S, et al: Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer. Oncogene 26: 54-64, 2007
24. Ganz T: Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3: 710-720, 2003.