Early-onset breast cancer in a Lebanese family with Lynch syndrome due to MSH2 gene mutation

Hereditary Cancer in Clinical Practice

Volumn 7, Issue 1, 2009, Pages

  Akoum, Riad ^a   Ghaoui, Albert ^b   Brihi, Emile ^a   Ghabash, Maroun ^b   Hajjar, Nicolas ^a  

^a RIZK HOSPITAL   (Lebanon)

^b Notre Dame du Rosaire Hospital   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ADULT; BREAST CANCER; BREAST CARCINOGENESIS; CANCER SCREENING; CASE REPORT; FEMALE; GENE INACTIVATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOTE; HUMAN; LEBANON; LETTER; MICROSATELLITE INSTABILITY; ONSET AGE; PHENOTYPE; POINT MUTATION; PREGNANT WOMAN;

EID: 79551571391     PISSN: 17312302     EISSN: 18974287     Source Type: Journal    
DOI: 10.1186/1897-4287-7-10     Document Type: Letter

References (9)

1. Vasen HF, Möslein G, Alonso A, Bernstein I, Bertario L, Blanco I, Burn J, Capella G, Engel C, Frayling I, Friedl W, Hes FJ, Hodgson S, Mecklin JP, Møller P, Nagengast F, Parc Y, Renkonen-Sinisalo L, Sampson JR, Stormorken A, Wijnen J. Guidelines for the clinical management of lynch syndrome (hereditary non-polyposis colorectal cancer). J Med Genet 2007, 44:353-362. 10.1136/jmg.2007.048991, 17327285.
2. Aarnio M, Mecklin JP, Aaltonen LA, Nyström-Lahti M, Järvinen HJ. Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer 1995, 64(6):430-433. 10.1002/ijc.2910640613, 8550246.
3. Müller A, Edmonston TB, Corao DA, Rose DG, Palazzo JP, Becker H, Fry RD, Rueschoff J, Fishel R. Exclusion of breast cancer as an integral tumor of Hereditary Non-Polyposis Colorectal Cancer. Cancer Res 2002, 62:1014-1019.
4. Scott RJ, McPhillips M, Meldrum CJ, Fitzgerald PE, Adams K, Spigelman AD, du Sart D, Tucker K, Kirk J. Hereditary Non-Polyposis Colorectal Cancer in 95 families: Differences and Similarities between Mutation-positive and Mutation-negative Kindreds. Am J Hum Genet 2001, 68:118-127. 1234904, 11112663, 10.1086/316942.
5. Wong EM, Tesoriero AA, Pupo GM, McCredie MR, Giles GG, Hopper JL, Mann GJ, Goldgar DE, Southey MC. kConFab; ABCFS Is MSH2 a breast cancer susceptibility gene?. Fam Cancer 2008, 7(2):151-155. 10.1007/s10689-007-9162-8, 17922223, kConFab; ABCFS.
6. Khilko N, Bourne P, Qi Y, Ping T. Mismatch repair genes hMLH1 and hMSH2 may not play an essential role in breast carcinogenesis. Int J Surg Pathol 2007, 15(3):233-241. 10.1177/1066896907302116, 17652529.
7. Akoum R, Ghaoui A, Brihi E, Ghabash M, Abou Atme J. Gynecological tumors revealing hereditary non-polyposis colorectal cancer: analysis of a large Lebanese pedigree. Int J Gyn Cancer 2006, 16(4):1516-1521.
8. Risinger JI, Barrett JC, Watson P, Lynch HT, Boyd J. Molecular genetic evidence of the occurrence of breast cancer as an integral tumor in patients with the hereditary nonpolyposis colorectal carcinoma syndrome. Cancer 1996, 77(9):1836-1843. 10.1002/(SICI)1097-0142(19960501)77:9<1836::AID-CNCR12>3.0.CO;2-0, 8646682.
9. Westenend PJ, Schütte R, Hoogmans MM, Wagner A, Dinjens WN. Breast cancer in an MSH2 gene mutation carrier. Hum Pathol 2005, 36(12):1322-1326. 10.1016/j.humpath.2005.08.025, 16311127.