Role of Ocimum sanctum as a genoprotective agent on chlorpyrifos-induced genotoxicity

Toxicology International

Volumn 18, Issue 1, 2011, Pages 9-13

  Khanna, Asha ^a   Shukla, Poonam ^b   Tabassum, Shajiya ^c  

^a ST ALOYSIUS COLLEGE   (India)

^b GOVERNMENT SCIENCE COLLEGE   (India)

^c Mata Gujri Women's College   (India)

Author keywords

Chlorpyrifos; chromosomal aberration; comet assay; Ocimum sanctum

Indexed keywords

CHLORPYRIFOS; DNA; OCIMUM SANCTUM EXTRACT;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME STRUCTURE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE; MITOSIS INDEX; NONHUMAN; RAT;

OCIMUM TENUIFLORUM; RATTUS;

EID: 79551564876     PISSN: 09716580     EISSN: None     Source Type: Journal    
DOI: 10.4103/0971-6580.75845     Document Type: Article

References (21)

1. WHO specifications and evaluations for public health pesticides, Evaluation Report 221, Chlorpyrifos. Geneva: WHO; 2002. p. 13.
2. Satyawati GV, Gupta KA, Tandon N. Ocimum sanctum (Linn.) in Medicinal Plants of India. New Delhi: Indian Council for Medical Research; 1987.
3. Aruna K, Shivaramakrishnan VM. Plant products as protective agents against cancer. Indian J Exp Biol 1990;28:1008-11.
4. Uma Devi P. Radio protective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulsi). Indian J Exp Biol 2001;39:185-90.
5. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Radiation protection by the Ocimum flavonoids orientin and vicenin: Mechanism of action. Radiat Res 2000;154:455-60.
6. Balaji M, Sasikala K. Cytogenetic effects of malathion in in vitro culture of human peripheral blood. Mutat Res 1993;301:13-7.
7. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91.
8. Nadin SB, Vargas-Roig LM, Ciocca DZ. A silver staining method for single-cell Gel Assay. J Histochem Cytochem 2001;49:1183-6.
9. Silva J, Freitas TR, Marinho JR, Speit G, Erdtmann B. An alkaline single-cell gel electrophoresis (comet) assay for environmental biomonitoring with native rodents. Genetics Mol Biol 2000;23:241-5.
10. Uma Devi P, Ganasoundari A. Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian J Exp Biol 1995;33:205-8.
11. Moorhead PS, Nowell PC, Mellman WJ, Battips DM, Hungerford DA. Chromosome preparations of Leucocytes Cultured from Human Peripheral Blood. Exp Cell Res 1960;20:613-6.
12. Rahman MF, Mahboob M, Danadevi K, Saleha Banu B, Grover P. Assessment of genotoxic effects of chlorpyrifos and acephate by comet assay in mice leukocytes. Mutat Res 2002;516:139-47.
13. Ribas G, Frenzilli G, Barale R, Marcos R. Herbicide-induced DNA damage in human lymphocytes evaluated by the single-cell gel electrophoresis (SCGE) assay, Mutat Res 1995;344:41-54.
14. Mehta A, Verma RS, Srivastava N. Chlorpyrifos induced DNA damage in rat liver and brain cells. Environ Mol Mutagen 2008;49:426-33.
15. Vigreux C, Poul JM, Deslandes E, Lebailly P, Godard T, Sichel F, et al. DNA damaging effects of pesticides measured by the single cell gel electrophoresis assay (comet assay) and the chromosomal aberration test, in CHOK1 cells. Mutat Res 1998;419:79-90.
16. Paramjit G, Danadevi K, Mahboob M, Rozati R, Banu BS, Rahman MF. Evaluation of genetic damage in workers employed in pesticide production utilizing the comet assay. Mutagenesis 2003;18:201-5.
17. Bolognesi C. Genotoxicity of pesticides: A review of human biomonitoring studies. Mutat Res 2003;543:251-72.
18. Awa AA.Chromosome damage in atomic bomb survivors and their offspring-Hiroshima and Nagasaki. In Radiation-induced cytogenetic damage in Man. T. Ishihara and M.S. Sasaki, ed. New York: Alan R. Liss; 1983;433-453
19. Au WW, Cantelli-Forti G, Hrelia, P, Legator MS. Cytogenetic assays in genotoxic studies, somatic cell effects of benzene and germinal cell effects of dibromochloropropane. Teratog Carcinog Mutagen 1990;10:125-34.
20. Von Sontag C. The chemical basis for Radiation Biology. London: Taylor and Francis; 1987.
21. Bagchi D, Bagchi M, Hassoun EA, Stohs SS. In vitro and in vivo generation of reactive oxygen species, DNA damage and LDH leakage by selected pesticides. Toxicol 1999;104:129-30.