Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients

Journal of Thoracic Oncology

Volumn 6, Issue 2, 2011, Pages 395-396

  Tibaldi, Carmelo ^a   Giovannetti, Elisa ^b,c   Vasile, Enrico ^a   Boldrini, Laura ^c   Gallegos Ruiz, Marielle I ^b   Bernardini, Ilaria ^a   Incensati, Roberto ^a   Danesi, Romano ^c   Cappuzzo, Federico ^a   Peters, Godefridus J ^b   Fontanini, Gabriella ^c  

^a Istituto Toscano Tumori   (Italy)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; K RAS PROTEIN;

AGED; BONE METASTASIS; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER STAGING; CASE REPORT; CODON; DISEASE COURSE; DNA ISOLATION; DRUG EFFICACY; EXON; FEMALE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CARCINOMA; LUNG LESION; LUNG NON SMALL CELL CANCER; NOTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC MUTATION; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR DIFFERENTIATION;

EID: 79551550773     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3182059a6f     Document Type: Article

References (4)

1. Girard N, Lou E, Azzoli CG, et al. Analysis of genetic variants in neversmokers with lung cancer facilitated by an internet-based blood collection protocol: a preliminary report. Clin Cancer Res 2010;16:755-763.
2. Bell DW, Gore I, Okimoto RA, et al. Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Nat Genet 2005;37:1315-1316.
3. Vikis H, Sato M, James M, et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res 2007;67:4665-4670.
4. Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005;97:643-655.