Effects of cross-sectional change on the isotachphoresis process for protein-separation chip design

Microsystem Technologies

Volumn 16, Issue 11, 2010, Pages 1931-1938

  Choi, Hongsoo ^a   Jeon, Youngwon ^b   Cho, Migyung ^c   Lee, Dong Yeon ^b   Shim, Jaesool ^b  

^a Korea Institute of Machine and Materials   (South Korea)

^b Yeungnam University   (South Korea)

^c Tongmyong University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BACK GROUND ELECTROLYTE; BENZOIC ACID; CAPROIC ACID; CHANNEL SHAPE; CHARGE CONSERVATION; CHARGED COMPONENTS; COMPUTER SIMULATION MODEL; DISPERSION ANALYSIS; MASS CONSERVATION; MOMENT ANALYSIS; PHYSICOCHEMICAL PROPERTY; PROTEIN SEPARATIONS; QUASI-STEADY STATE; SEPARATION CHIP; STRAIGHT CHANNEL;

ACETIC ACID; AMINO ACIDS; CHEMICAL PROPERTIES; ELECTRIC FIELDS; FINITE VOLUME METHOD; HYDROCHLORIC ACID;

COMPUTER SIMULATION;

EID: 79551549657     PISSN: 09467076     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00542-010-1105-x     Document Type: Article

References (16)

1. Bier M, Palusinski OA, Mosher RA, Saville DA (1983) Electropho-resis: mathematical modeling and computer simulation. Science 219:1281-1297
2. Cho M (2009) A simulation of advanced multi-dimensional isotach-ophoretic protein separation for optimal lab-on-a chip design. J Korea Inst Marit Inf Commun Sci 13:1475-1482
3. Everaerts FM, Beckers JL, Verheggen ThPEM (1976) Isotachophoresis: theory, instrumentation and applications. Elsevier, Amsterdam
4. Gebauer P, Boček P, Deml M, Janák J (1980) Isotachophoresis of kinetically labile complexes. J Chromatogr 199:81-94
5. Godkin JD, Bazer FW, Moffatt J, Sessions F, Roberts RM (1982) Purification and properties of a major, low molecular weight protein released by the trophoblast of sheep blastocysts at Day 13-21. J Reprod Fertil 65:141-150
6. Herr AE, Molho JI, Drouvalakis KA, Mikkelsen JC, Utz PJ, Santiago JG, Kenny TW (2003) On-chip coupling of isoelectric focusing and free solution electrophoresis for multidimensional separations. Anal Chem 75:1180-1187
7. Hruka V, Jaros M, Gas B (2006) Simul 5-Free dynamic simulator of electrophoresis. Electrophoresis 27:984-991
8. Hu S, Zhang Z, Cook LM, Carpenter EJ, Dovichi NJ (2000) Separation of proteins by sodium dodecylsulfate capillary electrophoresis in hydroxypropylcellulose sieving matrix with laser-induced fluorescence detection. J Chromatogr A 894:291-296
9. Jung B, Bharadwaj R, Santiago JG (2006) On-chip millionfold sample stacking using transient isotachophoresis. Anal Chem 78:2319-2327
10. Kendall J, Crittende ED (1923) The separation of isotopes. Proc Natl Acad Sci USA 9(3):75-78
11. Mikkers FEP, Everaerts FM, Peek JAF (1979) Isotachophoresis: the concepts of resolution, load capacity and separation efficiency. J Chromatogr 168:293-315
12. Shim J, Dutta P, Ivory CF (2007) Modeling and simulation of IEF in 2-D microgeometries. Electrophoresis 28:572-586
13. Thormann W, Mosher RA (2006) High-resolution computer simulation of the dynamics of isoelectric focusing using carrier ampholytes: focusing with concurrent electrophoretic mobilization is an isotachophoretic process. Electrophoresis 27:968-983
14. Thormann W, Mosher RA (2008) High-resolution computer simulation of electrophretic mobilization in isoelectric focusing. Electrophoresis 29:1676-1686
15. Walker PA III, Morris MD, Burns MA, Johnson BN (1998) Isotachophoretic separations on a Microchip. Normal Raman Spectroscopy detection. Anal Chem 70:3766-3769
16. Wang J, Zhang Y, Mohamadi MR, Kaji N, Tokeshi M, Baba Y (2009) Exceeding 20000-fold concentration of protein by the on-line isotachophoresis concentration in poly (methyl methacrylate) microchip. Electrophoresis 30:3250-3256