Radiosensitization and production of DNA double-strand breaks in U87MG brain tumor cells induced by tetraiodothyroacetic acid (tetrac)

Cell Cycle

Volumn 10, Issue 2, 2011, Pages 352-357

  Hercbergs, Aleck H ^a   Lin, Hung Yun ^b   Davis, Faith B ^b   Davis, Paul J ^b   Leith, John T ^c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b ORDWAY RESEARCH INSTITUTE   (United States)

^c Rhode Island Nuclear Science Center   (United States)

Author keywords

Comet assay; DNA double strand breaks; Radiation sensitivity; Tetrac; U87MG glioblastoma cells

Indexed keywords

DOUBLE STRANDED DNA; TETRAIODOTHYROACETIC ACID; TIRATRICOL; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TUMOR; CELL CYCLE; COMET ASSAY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IONIZING RADIATION; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOSENSITIZATION; X RAY;

MURINAE;

EID: 79551545359     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.2.14641     Document Type: Article

References (37)

1. Davis FB, Tang HY, Shih A, Keating T, Lansing L, Hercbergs AH, et al. Acting via a cell surface receptor, thyroid hormone is a growth factor for glioma cells. Cancer Res 2006; 66:7270-5. (Pubitemid 44197708)
2. Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev 2010; 31:139-70.
3. Bergh JJ, Lin HY, Lansing L, Mohamed SN, Davis FB, Mousa SA, Davis PJ. Integrin αvβ3 contains a cell surface receptor site for thyroid hormone that is linked to the activation of mitogen-activated protein kinase and induction of angiogenesis. Endocrinology 2005; 146:2864-71.
4. Cody V, Davis PJ, Davis FB. Molecular modeling of the thyroid hormone interactions with αvβ3 integrin. Steroids 2007; 72:165-70.
5. Davis FB, Mousa SA, O'Connor L, Mohamed S, Lin HY, Cao HJ, Davis PJ. Proangiogenic action of thyroid hormone is fibroblast-growth factor-dependent and is initiated at the cell surface. Circ Res 2004; 94:1500-13. (Pubitemid 38780323)
6. Mousa SA, Bergh JJ, Dier E, Rebbaa A, O'Connor LJ, Yalcin M, et al. Tetraiodothyroacetic acid, a small molecular weight integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor. Angiogenesis 2008; 11:183-90.
7. Yalcin M, Bharali DJ, Lansing L, Dyskin E, Mousa SS, Davis FB, et al. Tetraiodothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma. Anticancer Res 2009; 29:3825-31.
8. Yalcin M, Dyskin E, Lansing L, Mousa SS, Bridoux A, Hercbergs AH, et al. Tetraiodothyroacetic acid (tetrac) and nanoparticle tetrac arrest growth of human medullary carcinoma of the thyroid. J Clin Endocrinol Metab 2010; 95:1972-80.
9. Lin HY, Sun M, Tang HY, Lin C, Mousa SA, Incerpi S, et al. L-thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol-3-kinase. Am J Physiol Cell Physiol 2009; 296:980-91.
10. Yalcin M, Bharali DJ, Dyskin E, Dier E, Lansing L, Mousa SS, et al. Tetraiodothyroacetic acid and tetraiodothyroacetic acid nanoparticle effectively inhibit the growth of human follicular thyroid carcinoma. Thyroid 2010; 20:281-6.
11. Glinskii AB, Glinsky GV, Lin HY, Tang HY, Sun M, Davis FB, et al. Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac). Cell Cycle 2009; 8:3554-62.
12. Gladson CL. Expression of integrin αvβ3 in small blood vessels of glioblastoma tumors. J Neuropathol Exp Neurol 1996; 55:1143-9.
13. Schnell O, Krebs B, Wagner E, Beer AJ, Grau SJ, Goldbrunner RH, et al. Expression of alphavbeta3 integrin in patients with high and low grade gliomas. Proc Amer Assoc Cancer Res 2006; 47:226.
14. Hercbergs AH, Goyal LK, Suh JH, Reddy CA, Cohen BH, Stevens GH, et al. Propylthiouracil-induced chemical hypothyroidism with high-dose tamoxifen prolongs survival in recurrent high grade glioma: a phase I/II study. Anticancer Res 2003; 23:617-26.
15. Mishkin S, Morris HP, Yalovsky MA, Murthy PVN. Increased survival of rats bearing Morris hepatoma 7800 after induction of hypothyroidism. Cancer Res 1979; 39:2371-5. (Pubitemid 9203424)
16. Schmidinger M, Vogl UM, Bojie M, Lamm W, Heinzl M, Haitel A, et al. Hypothyroidism in patients with renal cell carcinoma: blessing or curse? Cancer 2010; Sept 15 (Epub ahead of print).
17. Baldazzi V, Tassi R, Lapini A, Santomaggio C, Carini M, Mazzanti R. The impact of sunitinib-induced hypothyroidism on progression-free survival of metastatic renal cancer patients: a prospective single-center study. Urol Oncol 2010; Sept 28 (Epub ahead of print).
18. Riesenbeck LM, Bierer S, Hoffmeister I, Kopke T, Paravassilis P, Hertle L, et al. Hypothyroidism correlates with a better prognosis in metastatic renal cancer patients treated with sorafenib or sunitinib. World J Urol 2010; Dec 14 (Epub ahead of print).
19. Rebbaa A, Chu F, Davis FB, Davis PJ, Mousa SA. Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent. Angiogenesis 2008; 11:269-76.
20. Hercbergs AH, Davis PJ, Davis FB, Cieslieski M, Leith JT. Radiosensitization of GL261 glioma cells by tetraiodothyroacetic acid (tetrac). Cell Cycle 2009; 8:2586-91.
21. Olive PL, Banath JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells using the "comet" assay. Radiation Res 1990; 122:86-94.
22. Olive PL, Durand RE, Riche IA, Olivetotto IA, Jackson SM. Gel electrophoresis of individual cells to quantify hypoxic fractions in human breast cancer. Cancer Res 1993; 53:733-6.
23. Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res 2001; 156:577-83.
24. Terato H, Tanaka TR, Hirayama R, Furusawa Y, Ide H. Analysis of complex DNA lesions generated by heavy ion beams. Nucleic Acids Symp Ser (Oxf ) 2007; 51:221-2.
25. Redon CE, Dickey JS, Nakamura AJ, Kareva IG, Naf D, Nowsheen S, et al. Tumor-induced complex DNA damage in distant proliferative tissues in vivo. Proc Natl Acad Sci (USA) 2010; 107:17992-7.
26. Pandita TK, Lieberman HB, Lim DS, Dhar S, Zheng W, Taya Y, Kastan MB. Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene 2001; 19:1386-91.
27. Rainey MD, Charlton ME, Stanton RV, Kastan MB. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity of ionizing radiation. Cancer Res 2008; 68:7466-74
28. Ponten J, MacIntyre EH. Long term culture of normal and neoplastic human glia. Acta Pathol Microbiol Scand 1968; 74:465-86.
29. Woo HK, Cho KK, Rha HK, Lee KJ, Park SC, Cho JK, et al. Photodynamic therapy with photofrin reduces invasiveness of U87 malignant glioma cells. J Korean Neurosurg Soc (Supplement) 2001; 30:189-96.
30. Fujiwara JM, Iwado E, Mills GB, Sawaya R, Kondo S, Kondo Y. Akt inhibitor shows anticancer and radiosensitizing effects in malignant cells by inducing autophagy. Int J Oncol 2007; 31:753-60.
31. Djuzenova CS, Guttler T, Berger S, Kartzer A, Flentje M. Differential response of human glioblastoma cell lines to combined campothecin and ionizing radiation treatment. Cancer Biol Ther 2008; 7:1-10.
32. Szalad A, Katakowski M, Zheng X, Jiang F, Chopp M. Transcription factor Sp1 induced ADAM17 and contributes to tumor cell invasiveness under hypoxia. J Exp Clin Cancer Res 2009; 28:129-40.
33. ATCC Catalogue of Cell Lines & Hybridomas, Rockville, MD 1992; 7:215-6.
34. Van Meir EG, Kikuchi T, Tada M, Li H, Diserens AC, Wojcik BE, et al. Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res 1994; 54:649-52.
35. O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 1997; 57:4285-300.
36. Gomez-Manzano C, Fueyo J, Kyritsis AP, Steck PA, Roth JA, McDonnel TJ, et al. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996; 56:694-9. (Pubitemid 26055454)
37. Goldstein A. Biostatistics, Academic Press 1995.