메뉴 건너뛰기




Volumn 107, Issue 4, 2011, Pages 562-570

Clinical and immunomodulatory effects of bevacizumab and low-dose interleukin-2 in patients with metastatic renal cell carcinoma: Results from a phase II trial

Author keywords

bevacizumab; immunomodulatory; low dose interleukin 2; phase II

Indexed keywords

BEVACIZUMAB; CD1C ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 8; TRANSCRIPTION FACTOR FOXP3;

EID: 79551541309     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2010.09573.x     Document Type: Article
Times cited : (18)

References (44)
  • 1
    • 0033514050 scopus 로고    scopus 로고
    • Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial
    • Medical Research Council Renal Cancer Collaborators.
    • Medical Research Council Renal Cancer Collaborators. Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial. Lancet 1999; 353: 14-7
    • (1999) Lancet , vol.353 , pp. 14-17
  • 2
    • 2442737061 scopus 로고    scopus 로고
    • Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
    • Pyrhönen S, Salminen E, Ruutu M, et al. Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J Clin Oncol 1999; 17: 2859-67
    • (1999) J Clin Oncol , vol.17 , pp. 2859-2867
    • Pyrhönen, S.1    Salminen, E.2    Ruutu, M.3
  • 3
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3
  • 4
    • 7144227930 scopus 로고    scopus 로고
    • Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie
    • Negrier S, Escudier B, Lasset C, et al. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N Engl J Med 1998; 338: 1272-8
    • (1998) N Engl J Med , vol.338 , pp. 1272-1278
    • Negrier, S.1    Escudier, B.2    Lasset, C.3
  • 6
    • 0042914703 scopus 로고    scopus 로고
    • Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
    • Yang JC, Sherry RM, Steinberg SM, et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol 2003; 21: 3127-32
    • (2003) J Clin Oncol , vol.21 , pp. 3127-3132
    • Yang, J.C.1    Sherry, R.M.2    Steinberg, S.M.3
  • 7
    • 16644401873 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • McDermott DF, Regan MM, Clark JI, et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 2005; 23: 133-41
    • (2005) J Clin Oncol , vol.23 , pp. 133-141
    • McDermott, D.F.1    Regan, M.M.2    Clark, J.I.3
  • 8
    • 0029812542 scopus 로고    scopus 로고
    • Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy
    • Fyfe GA, Fisher RI, Rosenberg SA, et al. Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy. J Clin Oncol 1996; 14: 2410-1
    • (1996) J Clin Oncol , vol.14 , pp. 2410-2411
    • Fyfe, G.A.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 9
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF,. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-80
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 10
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-34
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 11
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356: 125-34
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 12
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 13
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-11
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 14
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008; 33: 5422-8
    • (2008) J Clin Oncol , vol.33 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 15
    • 35648938219 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer
    • Bukowski RM, Kabbinavar FF, Figlin RA, et al. Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer. J Clin Oncol 2007; 25: 4536-41
    • (2007) J Clin Oncol , vol.25 , pp. 4536-4541
    • Bukowski, R.M.1    Kabbinavar, F.F.2    Figlin, R.A.3
  • 16
    • 4644224963 scopus 로고    scopus 로고
    • Effect of renal cell carcinomas on the development of type 1 T-cell responses
    • Rayman P, Wesa AK, Richmond AL, et al. Effect of renal cell carcinomas on the development of type 1 T-cell responses. Clin Cancer Res 2004; 10: 6360S-6S
    • (2004) Clin Cancer Res , vol.10
    • Rayman, P.1    Wesa, A.K.2    Richmond, A.L.3
  • 17
    • 34548162594 scopus 로고    scopus 로고
    • Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival
    • Griffiths RW, Elkord E, Gilham DE, et al. Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival. Cancer Immunol Immunother 2007; 56: 1743-53
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1743-1753
    • Griffiths, R.W.1    Elkord, E.2    Gilham, D.E.3
  • 18
    • 59249094500 scopus 로고    scopus 로고
    • Dysfunctional DC subsets in RCC patients: Ex vivo correction to yield an effective anti-cancer vaccine
    • Gigante M, Blasi A, Loverre A, et al. Dysfunctional DC subsets in RCC patients: ex vivo correction to yield an effective anti-cancer vaccine. Mol Immunol 2009; 46: 893-901
    • (2009) Mol Immunol , vol.46 , pp. 893-901
    • Gigante, M.1    Blasi, A.2    Loverre, A.3
  • 20
    • 33751512226 scopus 로고    scopus 로고
    • Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response
    • Sanarico N, Ciaramella A, Sacchi A, et al. Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response. J Leukoc Biol 2006; 80: 555-62
    • (2006) J Leukoc Biol , vol.80 , pp. 555-562
    • Sanarico, N.1    Ciaramella, A.2    Sacchi, A.3
  • 21
    • 33644784733 scopus 로고    scopus 로고
    • + regulatory T cells in cancer patients
    • + regulatory T cells in cancer patients. Blood 2006; 107: 2409-14
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 22
    • 0029842830 scopus 로고    scopus 로고
    • Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
    • Gabrilovich DI, Chen HL, Girgis KR, et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996; 2: 1096-103
    • (1996) Nat Med , vol.2 , pp. 1096-1103
    • Gabrilovich, D.I.1    Chen, H.L.2    Girgis, K.R.3
  • 23
    • 63549104097 scopus 로고    scopus 로고
    • Melanoma Study Group of the Mayo Clinic Cancer Center. Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma
    • Nevala WK, Vachon CM, Leontovich AA, Scott CG, Thompson MA, SN M,. Melanoma Study Group of the Mayo Clinic Cancer Center. Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma. Clin Cancer Res 2009; 15: 1931-9
    • (2009) Clin Cancer Res , vol.15 , pp. 1931-1939
    • Nevala, W.K.1    Vachon, C.M.2    Leontovich, A.A.3    Scott, C.G.4    Thompson, M.A.5    Sn, M.6
  • 24
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells
    • Oyama T, Ran S, Ishida T, et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol 1998; 160: 1224-32
    • (1998) J Immunol , vol.160 , pp. 1224-1232
    • Oyama, T.1    Ran, S.2    Ishida, T.3
  • 25
    • 33845343558 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
    • Li B, Lalani AS, Harding TC, et al. Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin Cancer Res 2006; 12: 6808-16
    • (2006) Clin Cancer Res , vol.12 , pp. 6808-6816
    • Li, B.1    Lalani, A.S.2    Harding, T.C.3
  • 26
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP,. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res 1999; 5: 2963-70
    • (1999) Clin Cancer Res , vol.5 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 27
    • 66849095271 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    • Sabatino M, Kim-Schulze S, Panelli MC, et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol 2009; 27: 2645-52
    • (2009) J Clin Oncol , vol.27 , pp. 2645-2652
    • Sabatino, M.1    Kim-Schulze, S.2    Panelli, M.C.3
  • 28
    • 0034946808 scopus 로고    scopus 로고
    • IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy
    • Wigginton JM, Gruys E, Geiselhart L, et al. IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy. J Clin Invest 2001; 108: 51-62
    • (2001) J Clin Invest , vol.108 , pp. 51-62
    • Wigginton, J.M.1    Gruys, E.2    Geiselhart, L.3
  • 29
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3
  • 30
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-16
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 31
    • 34547108341 scopus 로고    scopus 로고
    • Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    • Choueiri TK, Garcia JA, Elson P, et al. Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. Cancer 2007; 110 (3): 543-50
    • (2007) Cancer , vol.110 , Issue.3 , pp. 543-550
    • Choueiri, T.K.1    Garcia, J.A.2    Elson, P.3
  • 32
    • 34247524959 scopus 로고    scopus 로고
    • Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer
    • van der Vliet HJ, Koon HB, Yue SC, et al. Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin Cancer Res 2007; 13: 2100-8
    • (2007) Clin Cancer Res , vol.13 , pp. 2100-2108
    • Van Der Vliet, H.J.1    Koon, H.B.2    Yue, S.C.3
  • 33
    • 0034670053 scopus 로고    scopus 로고
    • A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment
    • Mosca PJ, Hobeika AC, Clay TM, et al. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood 2000; 96: 3499-504
    • (2000) Blood , vol.96 , pp. 3499-3504
    • Mosca, P.J.1    Hobeika, A.C.2    Clay, T.M.3
  • 34
    • 63149104648 scopus 로고    scopus 로고
    • Increased expression of IL-12p70 and IL-23 by multiple dendritic cell and macrophage subsets in plaque psoriasis
    • Yawalkar N, Tscharner GG, Hunger RE, Hassan AS,. Increased expression of IL-12p70 and IL-23 by multiple dendritic cell and macrophage subsets in plaque psoriasis. J Dermatol Sci 2009; 54: 99-105
    • (2009) J Dermatol Sci , vol.54 , pp. 99-105
    • Yawalkar, N.1    Tscharner, G.G.2    Hunger, R.E.3    Hassan, A.S.4
  • 35
    • 0343776164 scopus 로고    scopus 로고
    • Stimulatory and inhibitory maturation of human macrophage-derived dendritic cells
    • Chakraborty A, Li L, Chakraborty NG, Mukherji B,. Stimulatory and inhibitory maturation of human macrophage-derived dendritic cells. Pathobiology 1999; 67: 282-6
    • (1999) Pathobiology , vol.67 , pp. 282-286
    • Chakraborty, A.1    Li, L.2    Chakraborty, N.G.3    Mukherji, B.4
  • 36
    • 0033653874 scopus 로고    scopus 로고
    • Adherent dendritic cells expressing high levels of interleukin-10 and low levels of interleukin-12 induce antigen-specific tolerance to experimental autoimmune encephalomyelitis
    • Yang JS, Xu LY, Huang YM, Van Der Meide PH, Link H, Xiao BG,. Adherent dendritic cells expressing high levels of interleukin-10 and low levels of interleukin-12 induce antigen-specific tolerance to experimental autoimmune encephalomyelitis. Immunology 2000; 101: 397-403
    • (2000) Immunology , vol.101 , pp. 397-403
    • Yang, J.S.1    Xu, L.Y.2    Huang, Y.M.3    Van Der Meide, P.H.4    Link, H.5    Xiao, B.G.6
  • 37
    • 33644988431 scopus 로고    scopus 로고
    • + regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma
    • + regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma. J Clin Oncol 2006; 24: 1169-77
    • (2006) J Clin Oncol , vol.24 , pp. 1169-1177
    • Cesana, G.C.1    Deraffele, G.2    Cohen, S.3
  • 39
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Finke JH, Rini B, Ireland J, et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res 2009; 15: 2148-57
    • (2009) Clin Cancer Res , vol.15 , pp. 2148-2157
    • Finke, J.H.1    Rini, B.2    Ireland, J.3
  • 40
    • 65549141834 scopus 로고    scopus 로고
    • The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
    • Ozao-Choy J, Ma G, Kao J, et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res 2009; 69 (6): 2514-22
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2514-2522
    • Ozao-Choy, J.1    Ma, G.2    Kao, J.3
  • 41
    • 3242888623 scopus 로고    scopus 로고
    • Forecasting the cytokine storm following systemic interleukin (IL)-2 administration
    • Panelli MC, White R, Foster M, et al. Forecasting the cytokine storm following systemic interleukin (IL)-2 administration. J Transl Med 2004; 2: 17
    • (2004) J Transl Med , vol.2 , pp. 17
    • Panelli, M.C.1    White, R.2    Foster, M.3
  • 42
    • 0030798810 scopus 로고    scopus 로고
    • Clinical and immunomodulatory effects of repetitive 2-day cycles of high-dose continuous infusion IL-2
    • Engelhardt M, Wirth K, Mertelsmann R, Lindemann A, Brennscheidt U,. Clinical and immunomodulatory effects of repetitive 2-day cycles of high-dose continuous infusion IL-2. Eur J Cancer 1997; 3: 1050-4
    • (1997) Eur J Cancer , vol.3 , pp. 1050-1054
    • Engelhardt, M.1    Wirth, K.2    Mertelsmann, R.3    Lindemann, A.4    Brennscheidt, U.5
  • 43
    • 34249996750 scopus 로고    scopus 로고
    • Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets
    • Piccioli D, Tavarini S, Borgogni E, et al. Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets. Blood 2007; 109: 5371-9
    • (2007) Blood , vol.109 , pp. 5371-5379
    • Piccioli, D.1    Tavarini, S.2    Borgogni, E.3
  • 44
    • 37749004249 scopus 로고    scopus 로고
    • Basal cytokines profile in metastatic renal cell carcinoma patients treated with subcutaneous IL-2-based therapy compared with that of healthy donors
    • Guida M, Casamassima A, Monticelli G, Quaranta M, Colucci G,. Basal cytokines profile in metastatic renal cell carcinoma patients treated with subcutaneous IL-2-based therapy compared with that of healthy donors. J Transl Med 2007; 5: 51
    • (2007) J Transl Med , vol.5 , pp. 51
    • Guida, M.1    Casamassima, A.2    Monticelli, G.3    Quaranta, M.4    Colucci, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.