Feasibility of a liver transcriptomics approach to assess bovine treatment with the prohormone dehydroepiandrosterone (DHEA)

BMC Veterinary Research

Volumn 6, Issue , 2010, Pages

  Rijk, Jeroen C W ^a   Peijnenburg, Ad A C M ^a   Hendriksen, Peter J M ^a   Van Hende, Johan M ^b   Groot, Maria J ^a   Nielen, Michel W F ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BOVINAE;

PRASTERONE; RNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; CHEMISTRY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; LIVER; MALE; METABOLISM; METHODOLOGY; PRINCIPAL COMPONENT ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CATTLE; DEHYDROEPIANDROSTERONE; GENE EXPRESSION PROFILING; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 79551537507     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-6-44     Document Type: Article

References (28)

1. EEC Directive 96/22. Off J Eur Commun 1996, L125:3-9.
2. EEC Directive 96/23. Off J Eur Commun 1996, L125:10-32.
3. Stolker AAM, Zuidema T, Nielen MWF. Residue analysis of veterinary drugs and growth-promoting agents. Trends Anal Chem 2007, 26:967-979.
4. Simontacchi C, Perez De Altamirano T, Marinelli L, Angeletti R, Gabai G. Plasma steroid variations in bull calves repeatedly treated with testosterone, nortestosterone and oestradiol administered alone or in combination. Vet Res Comm 2004, 28:467-477.
5. Bovee TFH, Pikkemaat MG. Bioactivity-based screening of antibiotics and hormones. J Chromatogr A 2009, 1216:8035-8050. 10.1016/j.chroma.2009.03.045, 19342055.
6. Labrie F. Intracrinology. Mol Cell Endocrinol 1991, 78:113-118.
7. Labrie F, Belanger A, Luu-The V, Labrie C, Simard J, Cusan L, Gomez J-L, Candas B. DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: Its role during aging. Steroids 1998, 63:322-328. 10.1016/S0039-128X(98)00007-5, 9618795.
8. Dehennin L, Ferry M, Lafarge P, Peres G, Lafarge J-P. Oral administration of dehydroepiandrosterone to healthy men: Alteration of the urinary androgen profile and consequences for the detection of abuse in sport by gas chromatography-mass spectrometry. Steroids 1998, 63:80-87. 10.1016/S0039-128X(97)00138-4, 9516717.
9. Bahrke MS, Yesalis CE. Abuse of anabolic androgenic steroids and related substances in sport and exercise. Curr Opin Pharmacol 2004, 4:614-620. 10.1016/j.coph.2004.05.006, 15525553.
10. Reiter M, Walf VM, Christians A, Pfaffl MW, Meyer HHD. Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers. Anal Chim Acta 2007, 586:73-81. 10.1016/j.aca.2006.10.049, 17386698.
11. Toffolatti L, Rosa Gastaldo L, Patarnello T, Romualdi C, Merlanti R, Montesissa C, Poppi L, Castagnaro M, Bargelloni L. Expression analysis of androgen-responsive genes in the prostate of veal calves treated with anabolic hormones. Dom Anim Endocrinol 2005, 30:38-55.
12. Riedmaier I, Becker C, Pfaffl MW, Meyer HHD. The use of omic technologies for biomarker development to trace functions of anabolic agents. J Chromatogr A 2009, 1216:8192-8199. 10.1016/j.chroma.2009.01.094, 19233374.
13. Pfaffl MW, Daxenberger A, Hageleit M, Meyer HHD. Effects of synthetic progestagens on the mRNA expression of androgen receptor, progesterone receptor, oestrogen receptor α and ß, insulin-like growth factor-1 (IGF-1) and IGF-1 receptor in heifer tissues. J Vet Med A Physiol Pathol Clin Med 2002, 49:57-64.
14. White ME, Johnson BJ, Hathaway MR, Dayton WR. Growth factor messenger RNA levels in muscle and liver of steroid-implanted and nonimplanted steers. J Anim Sci 2003, 81:965-972.
15. Buterin T, Koch C, Naegeli H. Potential application of gene expression fingerprinting for food safety screening. Anal Chim Acta 2005, 529:33-39.
16. Carraro L, Ferraresso S, Cardazzo B, Romualdi C, Montesissa C, Gottardo F, Patarnello T, Castagnaro M, Bargelloni L. Expression profiling of skeletal muscle in young bulls treated with steroidal growth promoters. Physiol Genomics 2009, 38:138-148. 10.1152/physiolgenomics.00014.2009, 19383624.
17. Labrie F, Luu-The V, Calvo E, Martel C, Cloutier J, Gauthier S, Belleau P, Morisette J, Levesque M-H, Labrie C. Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid. J Endocrinol 2005, 184:427-433. 10.1677/joe.1.05997, 15684350.
18. Nuwaysir EF, Bittner M, Trent J, Barret JC, Afshari CA. Microarrays and toxicology: the advent of toxicogenomics. Mol Carcinog 1999, 24:153-159. 10.1002/(SICI)1098-2744(199903)24:3<153::AID-MC1>3.0.CO;2-P, 10204799.
19. Rijk JCW, Lommen A, Essers ML, Groot MJ, Van Hende JM, Doeswijk TG, Nielen MWF. Metabolomics approach to anabolic steroid urine profiling of bovines treated with prohormones. Anal Chem 2009, 81:6879-6888. 10.1021/ac900874m, 19618909.
20. Pellis L, Franssen-van Hal NLW, Burema J, Keijer J. The interclass correlation coefficient applied for evaluation of data correction, labeling methods, and rectal biopsy sampling in DNA microarray experiments. Physiol Genomics 2003, 16:99-106. 10.1152/physiolgenomics.00111.2003, 14570982.
21. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci 1998, 95:14863-14868. 10.1073/pnas.95.25.14863, 24541, 9843981.
22. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gilette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: A knowledge-based approach for interpreting genome wide expression profiles. PNAS 2005, 102:15545-15550. 10.1073/pnas.0506580102, 1239896, 16199517.
23. Coecke S, Vanhaecke T, Foriers A, Phillips IR, Vercruysse A, Shepard EA, Rogiers V. Hormonal regulation of glutathione S-transferase expression in co-cultured adult rat hepatocytes. J Endocrinol 2000, 166:363-371. 10.1677/joe.0.1660363, 10927625.
24. Ikeda H, Serria MS, Kakizaki I, Hatayama I, Satoh K, Tsuchida S, Muramatsu M, Nishi S, Sakai M. Activation of mouse Pi-class glutathione S-transferase gene by Nrf2 (NF-E2-related factor 2) and androgen. Biochem J 2002, 364:563-570. 10.1042/BJ20011756, 1222602, 12023900.
25. Depreter M, Vandesompele J, Espeel M, Speleman F, Roels F. Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications. J Endocrinol 2002, 175:779-792. 10.1677/joe.0.1750779, 12475388.
26. Hazeldine J, Arlt W, Lord JM. Dehydroepiandrosterone as a regulator of immune cell function. J Steroid Biochem Mol Biol
27. Gu S, Ripp SL, Prough RA, Geoghegan TE. Dehydroepiandrosterone affects the expression of multiple genes in rat liver including 11β-Hydroxysteroid Dehydrogenase Type 1: A cDNA Array Analysis. Mol Pharmacol 2003, 63:722-731. 10.1124/mol.63.3.722, 12606783.
28. Riedmaier I, Tichopad A, Reiter M, Pfaffl M, Meyer HHD. Identification of potential gene expression biomarkers for the surveillance of anabolic agents in bovine blood cells. Anal Chim Acta 2009, 638:106-113. 10.1016/j.aca.2009.02.014, 19298887.