The Influence of PRP on Early Bone Formation in Membrane Protected Defects. A Histological and Histomorphometric Study in the Rabbit Calvaria

Clinical Implant Dentistry and Related Research

Volumn 13, Issue 1, 2011, Pages 1-12

  Broggini, Nina ^a   Hofstetter, Willy ^a   Hunziker, Ernst ^a   Bosshardt, Dieter D ^a   Bornstein, Michael M ^a   Seto, Ichiro ^a   Weibrich, Gernot ^b   Buser, Daniel ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Autogenous bone; Bone graft; Bone healing; Bone regeneration; Calvarial bone defect; Platelet rich plasma

Indexed keywords

ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; BONE TRANSPLANTATION; COMPARATIVE STUDY; METHODOLOGY; NONPARAMETRIC TEST; PHYSIOLOGY; RABBIT; SKULL; THROMBOCYTE RICH PLASMA; TIME; WOUND HEALING;

ANIMALS; BONE REGENERATION; BONE TRANSPLANTATION; OSSEOINTEGRATION; OSTEOGENESIS; PLATELET-RICH PLASMA; RABBITS; SKULL; STATISTICS, NONPARAMETRIC; TIME FACTORS; WOUND HEALING;

EID: 79551531694     PISSN: 15230899     EISSN: 17088208     Source Type: Journal    
DOI: 10.1111/j.1708-8208.2009.00266.x     Document Type: Article

References (28)

1. Finkemeier CG. Bone-grafting and bone-graft substitutes. J Bone Joint Surg Am 2002; 84-A:454-464.
2. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62:489-496.
3. Pietramaggiori G, Scherer SS, Mathews JC, etal. Healing modulation induced by freeze-dried platelet-rich plasma and micronized allogenic dermis in a diabetic wound model. Wound Repair Regen 2008; 16:218-225.
4. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85:638-646.
5. Kassolis JD, Reynolds MA. Evaluation of the adjunctive benefits of platelet-rich plasma in subantral sinus augmentation. J Craniofac Surg 2005; 16:280-287.
6. Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study. Int J Oral Maxillofac Implants 2004; 19:59-65.
7. Ouyang XY, Qiao J. Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans. Chin Med J 2006; 119:1511-1521.
8. Suba Z, Takacs D, Gyulai-Gaal S, Kovacs K. Facilitation of beta-tricalcium phosphate-induced alveolar bone regeneration by platelet-rich plasma in beagle dogs: a histologic and histomorphometric study. Int J Oral Maxillofac Implants 2004; 19:832-838.
9. Wiltfang J, Schlegel KA, Schultze-Mosgau S, Nkenke E, Zimmermann R, Kessler P. Sinus floor augmentation with beta-tricalciumphosphate (beta-TCP): does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Implants Res 2003; 14:213-218.
10. Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study. J Oral Maxillofac Surg 2002; 60:1176-1181.
11. Furst G, Gruber R, Tangl S, etal. Sinus grafting with autogenous platelet-rich plasma and bovine hydroxyapatite. A histomorphometric study in minipigs. Clin Oral Implants Res 2003; 14:500-508.
12. Grageda E, Lozada JL, Boyne PJ, Caplanis N, McMillan PJ. Bone formation in the maxillary sinus by using platelet-rich plasma: an experimental study in sheep. J Oral Implantol 2005; 31:2-17.
13. Choi BH, Im CJ, Huh JY, Suh JJ, Lee SH. Effect of platelet-rich plasma on bone regeneration in autogenous bone graft. Int J Oral Maxillofac Surg 2004; 33:56-59.
14. Schenk RK, Olah AJ, Herrmann W. Preparation of calcified tissues for light microscopy. In: GR Dickson, ed. Methods of calcified tissue preparation. Amsterdam: Elsevier, 1984:1-56.
15. Weibrich G, Buch RS, Kleis WK, Hafner G, Hitzler WE, Wagner W. Quantification of thrombocyte growth factors in platelet concentrates produced by discontinuous cell separation. Growth Factors 2002; 20:93-97.
16. Weibel ER. Stereological methods. Vol. 1: practical methods for biological morphometry. New York: Academic Press, 1979.
17. Gundersen HJ, Jensen EB. The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987; 147:229-263.
18. Broggini N, Buser D, Cochran DL, etal. Glossary of oral and maxillofacial implants. Laney WR, ed. Berlin: Quintessence Publishing Co, Ltd, 2007:67.
19. Hsieh SC, Graves DT. Pulse application of platelet-derived growth factor enhances formation of a mineralizing matrix while continuous application is inhibitory. J Cell Biochem 1998; 69:169-180.
20. Wiltfang J, Kloss FR, Kessler P, etal. Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment. Clin Oral Implants Res 2004; 15:187-193.
21. Gerard D, Carlson ER, Gotcher JE, Jacobs M. Effects of platelet-rich plasma on the healing of autologous bone grafted mandibular defects in dogs. J Oral Maxillofac Surg 2006; 64:443-451.
22. Klongnoi B, Rupprecht S, Kessler P, Thorwarth M, Wiltfang J, Schlegel KA. Influence of platelet-rich plasma on a bioglass and autogenous bone in sinus augmentation. An explorative study. Clin Oral Implants Res 2006; 17:312-320.
23. Thor A, Wannfors K, Sennerby L, Rasmusson L. Reconstruction of the severely resorbed maxilla with autogenous bone, platelet-rich plasma, and implants: 1-year results of a controlled prospective 5-year study. Clin Implant Dent Relat Res 2005; 7:209-220.
24. Sanchez AR, Eckert SE, Sheridan PJ, Weaver AL. Influence of platelet-rich plasma added to xenogeneic bone grafts on bone mineral density associated with dental implants. Int J Oral Maxillofac Implants 2005; 20:526-532.
25. Weibrich G, Hansen T, Kleis W, Buch R, Hitzler WE. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 2004; 34:665-671.
26. Hollinger JO, Kleinschmidt JC. The critical size defect as an experimental model to test bone repair materials. J Craniofac Surg 1990; 1:60-68.
27. Frame JW. A convenient animal model for testing bone substitute materials. J Oral Surg 1980; 38:176-180.
28. Thorwarth M, Wehrhan F, Schultze-Mosgau S, Wiltfang J, Schlegel KA. PRP modulates expression of bone matrix proteins in vivo without long-term effects on bone formation. Bone 2006; 38:30-40.