Osteonecrosis of the Posterior Mandible after Implant Insertion: A Clinical and Histological Case Report

Clinical Implant Dentistry and Related Research

Volumn 13, Issue 1, 2011, Pages 58-63

  Favia, Gianfranco ^a   Piattelli, Adriano ^a   Sportelli, Pasquale ^a   Capodiferro, Saverio ^a   Iezzi, Giovanna ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Bisphosphonates; Clodronate; Dental implants; Osteonecrosis of the jaw

Indexed keywords

BONE DENSITY CONSERVATION AGENT; CLODRONIC ACID;

AGED; ARTICLE; BONE NECROSIS; BONE REGENERATION; CASE REPORT; DRUG EFFECT; FEMALE; HUMAN; JAW DISEASE; PATHOLOGY; TOOTH IMPLANTATION; TREATMENT FAILURE;

AGED; BONE DENSITY CONSERVATION AGENTS; CLODRONIC ACID; DENTAL IMPLANTS; FEMALE; HUMANS; MANDIBULAR DISEASES; OSSEOINTEGRATION; OSTEONECROSIS; TREATMENT FAILURE;

EID: 79551530654     PISSN: 15230899     EISSN: 17088208     Source Type: Journal    
DOI: 10.1111/j.1708-8208.2009.00181.x     Document Type: Article

References (26)

1. Kimmel DB. Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates. J Dent Res 2007; 86:1022-1033.
2. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 2004; 62:527-534.
3. Ficarra G, Beninati F, Rubino I, etal. Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonate treatment. J Clin Periodontol 2005; 32:1123-1128.
4. Landesberg R, Cozin M, Cremers S, etal. Inhibition of oral mucosal cell wound healing by bisphosphonates. J Oral Maxillofac Surg 2008; 66:839-847.
5. Bell BM, Bell RE. Oral bisphosphonates and dental implants: a retrospective study. J Oral Maxillofac Surg 2008; 66:1022-1024.
6. Hansen T, Kunke M, Weber A, Kirkpatrick CJ. Osteonecrosis of the jaws in patients treated with bisphosphonates - histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med 2006; 35:155-160.
7. Von Knoch F, Eckardt C, Alabre CI, Schneider E, Rubash HE, Shanbag AS. Anabolic effects of bisphosphonates on peri-implant bone stock. Biomaterials 2007; 28:3549-3559.
8. Naidu A, Dechow PC, Spears R, Wright JM, Kessler HP, Oppermann LA. The effect of bisphosphonates on osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106:829-837.
9. Magopoulos C, Karakinaris G, Telioudis Z, etal. Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals. Am J Otolaryngol 2007; 28:158-163.
10. Stefanik D, Sarin J, Lam T, Levin L, Leboy PS, Akintoye SO. Disparate osteogenic response of mandible and iliac crest bone marrow stromal cells to pamidronate. Oral Dis 2008; 14:465-471.
11. Boonyapakorn T, Schirmer I, Reichart PA, Sturdy I, Massenkeil G. Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies. Oral Oncol 2008; 44:857-869.
12. Hoff AO, Toth BB, Altundag K, etal. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res 2008; 23:826-836.
13. Ruggiero SL, Drew SJ. Osteonecrosis of the jaws and bisphosphonate therapy. J Dent Res 2007; 86:1013-1021.
14. Rizzoli R, Burlet N, Cahall D, etal. Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis. Bone 2008; 42:841-847.
15. Reid IR, Bolland MJ, Grey AB. Is bisphosphonate-associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone 2007; 41:318-320.
16. Migliorati CA, Schubert MM, Peterson DE, Seneda LM. Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer 2005; 104:83-93.
17. Bedogni A, Blandamura S, Lokomic Z, etal. Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105:358-364.
18. Bagan JV, Murillo J, Jimenez Y, etal. Avascular jaw osteonecrosis in association with cancer chemotherapy: series of 10 cases. J Oral Pathol Med 2005; 34:120-123.
19. Wang HL, Weber D, McCauley LK. Effect of long-term oral bisphosphonates on implant wound healing: literature review and a case report. J Periodontol 2007; 78:584-594.
20. Piattelli A, Scarano A, Quaranta M. High-precision, cost-effective system for producing thin sections of oral tissues containing dental implants. Biomaterials 1997; 18:577-579.
21. Sarin J, De Rossi SS, Akintoye SO. Updates on bisphosphonates and potential pathobiology of bisphosphonate-induced jaw osteonecrosis. Oral Dis 2008; 14:277-285.
22. Scully C, Madrid C, Bagan J. Dental endosseous implants in patients on bisphosphonate therapy. Implant Dent 2006; 15:212-218.
23. Grant BT, Amenedo C, Freeman K, Kraut RA. Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg 2008; 66:223-230.
24. Otomo-Corgel J. Implants and oral bisphosphonates: risky business. J Periodontol 2007; 74:373-376.
25. Sarasquete ME, Garcia-Sanz R, Marin L, etal. Bisphosphonate-related osteonecrosis of the jaws is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis. Blood 2008; 112:2709-2712.
26. Diehl IJ, Fogelman I, Al-Nawas B, etal. Pathophysiology, risk factors and management of bisphophonate-associated osteonecrosis of the jaw: is there a diverse relationship of amino- and non-aminobisphophonates? Crit Rev Oncol Hematol 2007; 64:198-207.