CYP2C19 genotype and outcomes of clopidogrel treatment [1]

New England Journal of Medicine

Volumn 364, Issue 5, 2011, Pages 481-482

  Geisler, Tobias ^a   Bigalke, Boris ^b   Schwab, Matthias ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 2C19; ADENOSINE DIPHOSPHATE; ALPHA2 INTEGRIN; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; PLACEBO; PURINERGIC P2Y12 RECEPTOR; ANTITHROMBOCYTIC AGENT; CYP2C19 PROTEIN, HUMAN; CYTOCHROME P450; CYTOCHROME P450 3A; DRUG DERIVATIVE; TICLOPIDINE; UNSPECIFIC MONOOXYGENASE;

ACUTE CORONARY SYNDROME; ALLELE; DRUG EFFECT; GENETIC ASSOCIATION; GENOTYPE; HEART ATRIUM FIBRILLATION; HIGH RISK POPULATION; HUMAN; LETTER; PHARMACOGENETICS; PRIORITY JOURNAL; RISK FACTOR; TREATMENT OUTCOME; BODY MASS; DIABETES MELLITUS; ENZYME METABOLISM; TREATMENT REFUSAL; GENETICS; METABOLISM; MUTATION; NOTE;

ACUTE CORONARY SYNDROME; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MUTATION; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; ATRIAL FIBRILLATION; GENOTYPE; RISK FACTORS;

EID: 79551524697     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1013331     Document Type: Letter

References (5)

1. Paré G, Mehta SR, Yusuf S, et al. Effects of CYP2C19 genotype on outcomes of clopidogrel treatment. N Engl J Med 2010; 363:1704-14.
2. Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360:354-62.
3. Geisler T, Schaeffeler E, Dippon J, et al. CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. Pharmacogenomics 2008;9:1251-9.
4. Hochholzer W, Trenk D, Fromm MF, et al. Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement. J Am Coll Cardiol 2010;55:2427-34.
5. Geisler T, Grass D, Bigalke B, et al. The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score. J Thromb Haemost 2008;6:54-61.