Transplantation of human adipose tissue-derived multilineage progenitor cells reduces serum cholesterol in hyperlipidemic watanabe rabbits

Tissue Engineering - Part C: Methods

Volumn 17, Issue 2, 2011, Pages 145-154

  Okura, Hanayuki ^a,b   Saga, Ayami ^a   Fumimoto, Yuichi ^a   Soeda, Mayumi ^a   Moriyama, Mariko ^a,c   Moriyama, Hiroyuki ^c   Nagai, Koji ^a,d   Lee, Chun Man ^a   Yamashita, Shizuya ^e   Ichinose, Akihiro ^d   Hayakawa, Takao ^c   Matsuyama, Akifumi ^a  

^a FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c KINKI UNIVERSITY   (Japan)

^d KOBE UNIVERSITY HOSPITAL   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHOLESTEROL; DISEASES; HUMAN ENGINEERING; PHYSIOLOGICAL MODELS; PUMPS;

ANIMAL MODEL; ANTITRYPSIN; CELL THERAPY; HIGH CONCENTRATION; HUMAN ADIPOSE TISSUE; HUMAN BILE; HUMAN FACTORS; HYPERCHOLESTEROLEMIA; IN-VIVO; LIVER DISEASE; LOW DENSITY LIPOPROTEINS; METABOLIC DEFECTS; PORTAL VEINS; PROGENITOR CELL; SERUM CHOLESTEROL;

DISEASE CONTROL;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

BIOLOGICAL MARKER; CHOLESTEROL;

ADIPOSE TISSUE; ADULT; ANIMAL; ARTICLE; BLOOD; CELL DIFFERENTIATION; CELL LINEAGE; CELL SHAPE; CELL SURVIVAL; CYTOLOGY; FEMALE; HUMAN; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL; MALE; METABOLISM; MIDDLE AGED; RABBIT; STEM CELL; STEM CELL TRANSPLANTATION;

ADIPOSE TISSUE; ADULT; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; CELL SHAPE; CELL SURVIVAL; CHOLESTEROL; FEMALE; HEPATOCYTES; HUMANS; HYPERLIPIDEMIAS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSION; MALE; MIDDLE AGED; RABBITS; STEM CELL TRANSPLANTATION; STEM CELLS; YOUNG ADULT;

EID: 79551516124     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2010.0139     Document Type: Article

References (28)

1. Brown, M.S., and Goldstein, J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34, 1986.
2. Havel, R.J., Yamada, N., and Shames, D.M. Watanabe heritable hyperlipidemic rabbit. Animal model for familial hy-percholesterolemia. Arteriosclerosis 9(1 Suppl), I33, 1989.
3. Yamamoto, T., Bishop, R.W., Brown, M.S., Goldstein, J.L., and Russell, D.W. Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science 32, 1230, 1986.
4. Bujo, H., Takahashi, K., Saito, Y., Maruyama, T., Yamashita, S., Matsuzawa, Y., Ishibashi, S., Shionoiri, F., Yamada, N., and Kita, T. Clinical features of familial hypercholester-olemia in Japan in a database from 1996-1998 by the research committee of the ministry of health, labour and welfare of Japan. J Atheroscler Thromb 11, 146, 2004.
5. Yamashita, S., Hbujo, H., Arai, H., Harada-Shiba, M., Matsui, S., Fukushima, M., Saito, Y., Kita, T., and Matsuzawa, Y. Long-term probucol treatment prevents secondary cardiovascular events: a cohort study of patients with heterozygous familial hypercholesterolemia in Japan. J Atheroscler Thromb 15, 292, 2008.
6. Gunsalus, J.R., Brady, D.A., Coulter, S.M., Gray, B.M., and Edge, A.S. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med 3, 48, 1997.
7. Tejera, M.L., Cienfuegos, J.A., Maganto, P., Pardo, F., San-tamaria, L., Codesal, J., De Andres, S., Hernandez, J.L., and Castillo-Olivares, J.L. Reduction of cholesterol levels following liver cell grafting in hyperlipidemic (WHHL) rabbits. Transplant Proc 24, 160, 1992.
8. Wang, J., Pollak, R., and Bartholomew, A. Sustained reduction of serum cholesterol levels following allo-trans-plantation of parenchymal hepatocytes in Watanabe rabbits. Transplant Proc 23, 894, 1991.
9. Wiederkehr, J.C., Kondos, G.T., and Pollak, R. Hepatocyte transplantation for the low-density lipoprotein receptor-deficient state. A study in the Watanabe rabbit. Transplantation 50, 466, 1990.
10. Chowdhury, J.R., Grossman, M., Gupta, S., Chowdhury, N.R., Baker, J.R., Jr., and Wilson, J.M. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 254, 1802, 1991.
11. Ishibashi, S., Brown, M.S., Goldstein, J.L., Gerard, R.D., Hammer, R.E., and Herz, J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92, 883, 1993.
12. Kozarsky, K.F., McKinley, D.R., Austin, L.L., Raper, S.E., Stratford-Perricaudet, L.D., and Wilson, J.M. In vivo correction of low density lipoprotein receptor deficiency in the Wata-nabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 269, 13695, 1994.
13. Wilson, J.M., Chowdhury, N.R., Grossman, M., Wajsman, R., Epstein, A., Mulligan, R.C., and Chowdhury, J.R. Temporary amelioration of hyperlipidemia in low density lipo-protein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc Natl Acad Sci USA 87, 8437, 1990.
14. Okura, H., Komoda, H., Saga, A., Kakuta-Yamamoto, A., Hamada, Y., Fumimoto, Y., Lee, C.M., Ichinose, A., Sawa, Y., and Matsuyama, A. Properties of hepatocyte-like cell clusters from human adipose tissue-derived mesenchymal stem cells. Tissue Eng Part C Methods 16, 761, 2010.
15. Banas, A., Teratani, T., Yamamoto, Y., Tokuhara, M., Take-shita, F., Quinn, G., Okochi, H., and Ochiya, T. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology 46, 219, 2007.
16. Seo, M.J., Suh, S.Y., Bae, Y.C., and Jung, J.S. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun 328, 258, 2005.
17. Komoda, H., Okura, H., Lee, C.M., Sougawa, N., Iwayama, T., Hashikawa, T., Saga, A., Yamamoto, A., Ichinose, A., Murakami, S., Sawa, Y., and Matsuyama, A. Reduction of N-glycolylneuraminic acid xenoantigen on human adipose tissue-derived stromal cells/mesenchymal stem cells leads to safer and more useful cell sources for various stem cell therapies. Tissue Eng Part A 16, 1143, 2010.
18. Okura, H., Matsuyama, A., Lee, C.M., Saga, A., Kakuta-Yamamoto, A., Nagao, A., Sougawa, N., Sekiya, N., Take-kita, K., Shudo, Y., Miyagawa, S., Komoda, H., Okano, T., and Sawa, Y. Cardiomyoblast-like cells differentiated from human adipose tissue-derived mesenchymal stem cells improve left ventricular dysfunction and survival in a rat myocardial infarction model. Tissue Eng Part C Methods 16, 417, 2010.
19. Bjorntorp, P., Karlsson, M., Pertoft, H., Pettersson, P., Sjos-trom, L., and Smith, U. Isolation and characterization of cells from rat adipose tissue developing into adipocytes. J Lipid Res 19, 316, 1978.
20. Zuk, P.A., Zhu, M., Ashjian, P., De Ugarte, D.A., Huang, J.I., Mizuno, H., Alfonso, Z.C., Fraser, J.K., Benhaim, P., and Hedrick, M.H. Human adipose tissue is a source of multi-potent stem cells. Mol Biol Cell 13, 4279, 2002.
21. Nicklas, J.A., and Buel, E. Development of an Alu-based, real-time PCR method for quantitation of human DNA in forensic samples. J Forensic Sci 48, 936, 2003.
22. Opel, K.L., Fleishaker, E.L., Nicklas, J.A., Buel, E., and McCord, B.R. Evaluation and quantification of nuclear DNA from human telogen hairs. J Forensic Sci 53, 853, 2008.
23. Okazaki, M., Usui, S., Ishigami, M., Sakai, N., Nakamura, T., Matsuzawa, Y., and Yamashita, S. Identification of unique lipoprotein subclasses for visceral obesity by component analysis of cholesterol profile in high-performance liquid chromatography. Arterioscler Thromb Vasc Biol 25, 578, 2005.
24. Bier, D.M., and Havel, R.J. Activation of lipoprotein lipase by lipoprotein fractions ofhuman serum. J Lipid Res 11, 565, 1970.
25. Steinberg, D., and Witztum, J.L. Current concepts. Lipo-proteins and atherogenesis. Current concepts. JAMA 264, 3047, 1990.
26. Hughes, R.D., Mitry, R.R., and Dhawan, A. Hepatocyte transplantation for metabolic liver disease: UK experience. J R Soc Med 98, 341, 2005.
27. Gimble, J.M., Katz, A.J., and Bunnell, B.A. Adipose-derived stem cells for regenerative medicine. Circ Res 100, 1249, 2007.
28. Bilheimer, D.W., Goldstein, J.L., Grundy, S.M., Starzl, T.E., and Brown, M.S. Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N Engl J Med 311, 1658, 1984.