Macrolides and community-acquired pneumonia: Is quorum sensing the key?

Critical Care

Volumn 14, Issue 4, 2010, Pages

  Wise, Matt P ^a   Williams, David W ^b   Lewis, Michael A O ^b   Frost, Paul J ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CHEMOKINE; CLARITHROMYCIN; CYTOKINE; MACROLIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT;

ARTIFICIAL VENTILATION; ASTHMA; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOFILM; CELL COMMUNICATION; CHRONIC LUNG DISEASE; COMMUNITY ACQUIRED PNEUMONIA; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG TARGETING; ENTERITIS; ESCHERICHIA COLI; HUMAN; IMMUNOMODULATION; LOW DRUG DOSE; MONOTHERAPY; MORTALITY; MULTICENTER STUDY (TOPIC); NONHUMAN; NOTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSORIASIS; QUORUM SENSING; RHINOSINUSITIS; ROSACEA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; VIRUS PNEUMONIA; WEANING; WILD TYPE; ARTICLE; BACTERIAL PNEUMONIA; COMMUNICABLE DISEASE; DRUG COMBINATION; DRUG EFFECT; MICROBIOLOGY;

ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; DRUG THERAPY, COMBINATION; HUMANS; MACROLIDES; PNEUMONIA, BACTERIAL; QUORUM SENSING;

EID: 79551515919     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9084     Document Type: Note

References (15)

1. Lipman J, Boots R. A new paradigm for treating infections 'go hard and go home'. Crit Care Resusc 2009, 11:276-281.
2. Restrepo MI, Mortensen EM, Rello J, Brody J, Anzueto A. Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortality. Chest 2010, 137:552-557. 10.1378/chest.09-1547, 19880910.
3. McCabe C, Kirchner C, Zhang H, Daley J, Fisman DN. Guideline-concordant therapy and reduced mortality and length of stay in adults with community-acquired pneumonia: playing by the rules. Arch Intern Med 2009, 169:1525-1531. 10.1001/archinternmed.2009.259, 19752411.
4. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG, . Infectious Diseases Society of America; American Thoracic Society Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community acquired pneumonia in adults. Clin Infect Dis 2007, 44(Suppl 2):S27-S72. 10.1086/511159, 17278083, Infectious Diseases Society of America; American Thoracic Society.
5. Lim WS, Baudouin SV, George RC, Hill AT, Jamieson C, Le Jeune I, Macfarlane JT, Read RC, Roberts HJ, Levy ML, Wani M, Woodhead MA, . Pneumonia Guidelines Committee of the BTS Standards of Care Committee BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 2009, 64(Suppl 3):iii1-iii55. 10.1136/thx.2009.121434, 19783532, Pneumonia Guidelines Committee of the BTS Standards of Care Committee.
6. Martin-Loeches I, Lisboa T, Rodriguez A, Putensen C, Annane D, Garnacho-Montero J, Restrepo MI, Rello J. Combination antibiotic therapy withmacrolides improves survival in intubated patients with community-acquired pneumonia. Intensive Care Med 2010, 36:612-620. 10.1007/s00134-009-1730-y, 19953222.
7. Roig J, Casal J, Gispert P, Gea E. Antibiotic therapy of community-acquired pneumonia (CAP) caused by atypical agents. Med Mal Infect 2006, 36:680-689. 10.1016/j.medmal.2006.07.020, 17095177.
8. Baddour LM, Yu VL, Klugman KP, Feldman C, Ortqvist A, Rello J, Morris AJ, Luna CM, Snydman DR, Ko WC, Chedid MB, Hui DS, Andremont A, Chiou CC, . International Pneumococcal Study Group Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteraemia. Am J Respir Crit Care Med 2004, 170:400-404. 10.1164/rccm.200311-1578OC, 15130905, International Pneumococcal Study Group.
9. Shinkai M, Henke MO, Rubin BK. Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action. Pharmacol Ther 2008, 117:393-405. 10.1016/j.pharmthera.2007.11.001, 18289694.
10. Njoroge J, Sperandio V. Jamming bacterial communication: new approaches for the treatment of infectious diseases. EMBO Mol Med 2009, 1:201-210. 2801573, 20049722, 10.1002/emmm.200900032.
11. Oggioni MR, Trappetti C, Kadioglu A, Cassone M, Iannelli F, Ricci S, Andrew PW, Pozzi G. Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis. Mol Microbiol 2006, 61:1196-1210. 1618759, 16925554, 10.1111/j.1365-2958.2006.05310.x.
12. Hall-Stoodley L, Stoodley P. Evolving concepts in biofilm infections. Cell Microbiol 2009, 11:1034-1043. 10.1111/j.1462-5822.2009.01323.x, 19374653.
13. Nalca Y, Jansch L, Bredenbruch F, Geffers R, Buer J, Haussler S. Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach. Antimicrob Agents Chemother 2006, 50:1680-1688. 1472232, 16641435, 10.1128/AAC.50.5.1680-1688.2006.
14. Giamarellos-Bourboulis EJ, Pechere JC, Routsi C, Plachouras D, Kollias S, Raftogiannis M, Zervakis D, Baziaka F, Koronaios A, Antonopoulou A, Markaki V, Koutoukas P, Papadomichelakis E, Tsanganos T, Armaganidis A, Koussoulas V, Kotanidou A, Roussos C, Giamarellou H. Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia. Clin Infect Dis 2008, 46:1157-1164. 10.1086/529439, 18444850.
15. Lesprit P, Faurisson F, Join-Lambert O, Roudot-Thoraval F, Foglino M, Vissuzaine C, Carbon C. Role of the quorum-sensing system in experimental pneumonia due to Pseudomonas aeruginosa in rats. Am J Respir Crit Care Med 2003, 167:1478-1482. 10.1164/rccm.200207-736BC, 12569080.