The devil's advocacy: When and why inhaled therapies for tuberculosis may not work

Tuberculosis

Volumn 91, Issue 1, 2011, Pages 65-66

  Yadav, Awadh Bihari ^a,b   Singh, Amit K ^a   Verma, Rahul K ^a   Mohan, Mradul ^a   Agrawal, Atul K ^a   Misra, Amit ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Drug resistance; Granuloma; Inhalation; Pulmonary; Respirable

Indexed keywords

ISONIAZID; RIFABUTIN; TUBERCULOSTATIC AGENT;

AIRWAY; ANTIBIOTIC RESISTANCE; ANTIGEN PRESENTATION; ARTICLE; HUMAN; IMMUNOPATHOLOGY; INFLAMMATION; LUNG TUBERCULOSIS; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ANTITUBERCULAR AGENTS; BIOFILMS; HUMANS; LUNG; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; TREATMENT FAILURE; TUBERCULOSIS, PULMONARY;

EID: 79551504294     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2010.10.001     Document Type: Article

References (12)

1. M.D. Iseman Some healthy skepticism about inhaled therapy for tuberculosis Clin Infect Dis 33 2001 266 267
2. L.V. Sacks, S. Pendle, D. Orlovic, M. Andre, M. Popara, and G. Moore Adjunctive salvage therapy with inhaled aminoglycosides for patients with persistent smear positive pulmonary tuberculosis Clin Infect Dis 32 2001 44 49
3. W.J. Koh, O.J. Kwon, G.Y. Suh, M.P. Chung, H. Kim, and N.Y. Lee Six month therapy with aerosolized interferon-gamma for refractory multidrug-resistant pulmonary tuberculosis J Korean Med Sci 19 2004 167 171
4. A.K. Ojha, A.D. Baughn, D. Sambandan, T. Hsu, X. Trivelli, and Y. Guerardel Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria Mol Microbiol 69 2008 164 174
5. R.K. Verma, J. Kaur, K. Kumar, A.B. Yadav, and A. Misra Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice Antimicrob Agents Chemother 52 2008 3195 3201
6. P. Muttil, J. Kaur, K. Kumar, A.B. Yadav, R. Sharma, and A. Misra Inhalable microparticles containing large payload of anti-tuberculosis drugs Eur J Pharm Sci 32 2007 140 150
7. J. Kaur, P. Muttil, R.K. Verma, K. Kumar, A.B. Yadav, and R. Sharma A hand-held apparatus for "nose-only" exposure of mice to inhalable microparticles as a dry powder inhalation targeting lung and airway macrophages Eur J Pharm Sci 34 2008 56 65
8. R. Sharma, P. Muttil, A.B. Yadav, S.K. Rath, V.K. Bajpai, and U. Mani Uptake of inhalable microparticles affects defence responses of macrophages infected with Mycobacterium tuberculosis H37Ra J Antimicrob Chemother 59 2007 499 506
9. A.B. Yadav, and A. Misra Enhancement of apoptosis of THP-1 cells infected with Mycobacterium tuberculosis by inhalable microparticles and relevance to bactericidal activity Antimicrob Agents Chemother 51 2007 3740 3742
10. M. Bivas-Benita, K.E. van Meijgaarden, K.L. Franken, H.E. Junginger, G. Borchard, and T.H. Ottenhoff Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A (*)0201- restricted T-cell epitopes of Mycobacterium tuberculosis Vaccine 22 2004 1609 1615
11. R. Bellamy, N. Beyers, K.P. McAdam, C. Ruwende, R. Gie, and P. Samaai Genetic susceptibility to tuberculosis in Africans: a genome-wide scan Proc Natl Acad Sci U S A 97 2000 8005 8009
12. A.B. Yadav, P. Muttil, A.K. Singh, R.K. Verma, M. Mohan, and A.K. Agrawal Microparticles induce variable levels of activation in macrophages infected with Mycobacterium tuberculosis Tuberculosis (Edinb) 90 2010 188 196