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Volumn 19, Issue 3, 2011, Pages 1205-1221

Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies

(8) Nemoto, Toru a Yamamoto, Naoshi a Watanabe, Akio a Fujii, Hideaki a Hasebe, Ko b Nakajima, Mayumi b Mochizuki, Hidenori b Nagase, Hiroshi a

a KITASATO UNIVERSITY (Japan)

b TORAY INDUSTRIES INC (Japan)

Author keywords

6,14 Epoxymorphinan; Analgesics; Naltrexone; Opioid

Indexed keywords

(2) N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] (3 FURYL)ACRYLAMIDE; (2) N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] (3 FURYL)ACRYLAMIDE; 2 PHENYL N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL]ACETAMIDE; 2 PHENYL N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL]ACETAMIDE; 6,14 EPOXYMORPHINAN DERIVATIVE; ACETIC ACID; KAPPA OPIATE RECEPTOR AGONIST; N [(17 BENZYL 6B,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 2 HYDROXYBENZAMIDE; N [(17 BENZYL 6B,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 3 HYDROXYBENZAMIDE; N [(17 BENZYL 6B,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 4 FLUOROBENZAMIDE; N [(17 BENZYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 3 FLUOROBENZAMIDE; N [(17 BENZYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL]BENZAMIDE; N [(17 BENZYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN-6ALPHS YL)METHYL] 4 HYDROXYBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 2 METHYLBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 3 HYDROXYBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 3 METHYLBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 4 HYDROXYBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] 4 METHYLBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 HYDROXYMORPHINAN 6ALPHA YL)METHYL] N METHYLBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 2 METHYLBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 3 METHOXYBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 3 METHYLBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 4 METHOXYBENZAMIDE; N [(17 CYCLOPROPYLMETHYL 6BETA,14BETA EPOXY 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 4 METHYLBENZAMIDE; N [(6BETA,14BETA EPOXY 17 ISOBUTYL 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 3 METHOXYBENZAMIDE; N [(6BETA,14BETA EPOXY 17 ISOBUTYL 3 METHOXYMORPHINAN 6ALPHA YL)METHYL] 4 METHOXYBENZAMIDE; N [(6BETA,14BETA EPOXY 17 ISOBUTYL 3 METHOXYMORPHINAN 6ALPHA YL)METHYL]BENZAMIDE; N [(6BETA,14BETA EPOXY 17 ISOBUTYL 3 METHOXYMORPHINAN 6AYL)METHYL] 2 METHOXYBENZAMIDE; NALTREXONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; BENZAMIDES; DRUG DESIGN; EPOXY COMPOUNDS; MALE; MICE; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; MORPHINANS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, KAPPA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79551498699 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.12.035 Document Type: Article

Times cited : (16)

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