Meta-analysis finds screening for prostate cancer with PSA does not reduce prostate cancer-related or all-cause mortality but results likely due to heterogeneity - The two highest quality studies identified do find prostate cancer-related mortality reductions

Evidence-Based Medicine

Volumn 16, Issue 1, 2011, Pages 20-21

  Roobol, Monique J ^a   Carlsson, Sigrid ^b   Hugosson, Jonas ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

CANCER MORTALITY; CANCER SCREENING; CANCER STAGING; CLINICAL RESEARCH; CORRELATION ANALYSIS; DIGITAL RECTAL EXAMINATION; EARLY DIAGNOSIS; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; NOTE; PROSTATE CANCER; QUALITY CONTROL; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; SAMPLE SIZE; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW;

EID: 79551494050     PISSN: 13565524     EISSN: 14736810     Source Type: Journal    
DOI: 10.1136/ebm1165     Document Type: Note

References (6)

1. Schröder FH, Hugosson J, Roobol MJ, et al.; ERSPC Investigators. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 2009;360:1320-8.
2. Labrie F, Candas B, Cusan L, et al. Screening decreases prostate cancer mortality: 11-year follow-up of the 1988 Quebec prospective randomized controlled trial. Prostate 2004;59:311-18.
3. Sandblom G, Varenhorst E, Löfman O, et al. Clinical consequences of screening for prostate cancer: 15 years follow-up of a randomised controlled trial in Sweden. Eur Urol 2004;46:717-23; discussion 724.
4. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
5. Hugosson J, Carlsson S, Aus G, et al. Mortality results from the Göteborg randomised population-based prostate-cancer screening trial. Lancet Oncol 2010;11:725-32.
6. Andriole GL, Crawford ED, Grubb RL 3rd, et al.; PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009;360:1310-19.