Anti-HIV-1 activity and structure-activity relationship of pyranocoumarin analogs

Yaoxue Xuebao

Volumn 46, Issue 1, 2011, Pages 35-38

  Dong, Biao ^a   Ma, Tao ^b   Zhang, Tian ^a   Zhou, Chun Mei ^b   Liu, Gang ^b   Wang, Lin ^b   Tao, Pei Zhen ^a   Zhang, Xing Quan ^c  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiviral activity; Calanolide A derivative; Human immunodeficiency virus type 1; Structure activity relationship

Indexed keywords

PROTEINASE; PYRANOCOUMARIN DERIVATIVE; TRANSCRIPTASE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL FREE SYSTEM; CHEMICAL STRUCTURE; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELLS, CULTURED; HIV CORE PROTEIN P24; HIV PROTEASE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; LEUKOCYTES, MONONUCLEAR; PYRANOCOUMARINS; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 79551492182     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Sobieszczyk ME, Taylor BS, Hammer SM. Antiretroviral agents [M]//Richman DD, Whiteley RJ, Hayden FG Clinical Virology. 3rd ed. Washington DC: ASM Press, 2009: 167-216.
2. Ma T, Liu L, Xue H, et al. The chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents [J]. J Med Chem, 2008, 51: 1432-1446. (Pubitemid 351484798)
3. Ma T, Wang L, Cheng GF, et al. Synthesis of calophyllolide analogue and its preliminary anti-inflammatory activity [J]. Acta Pharm Sin, 2010, 45: 1265-1269.
4. Wang L, Zhang XQ, Chen HS, et al. Improved synthesis and pharmacological evaluation of racemic 11-demethylcalanolide A [J]. Acta Pharm Sin, 2008, 43: 707-718.
5. Matayoshi ED, Wang GT, Krafft GA, et al. Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer [J]. Science, 1990, 247: 954-958. (Pubitemid 20081658)
6. D'Aquila RT, Summers WC. HIV-1 reverse transcriptase/ribonuclease H: high level expression in Escherichia coli from a plasmid constructed using the polymerase chain reaction [J]. J Acquir Immune Defic Syndr, 1989, 2: 579-587.
7. Harishorn KL, Vogt MW, Chou TC, et al. Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon [J]. Antimicrob Agents Chemother, 1987, 31: 168-172.
8. Zhang XQ, Sorensen M, Fung M, et al. Synergistic in vitro antiretroviral activity of a humanized monoclonal anti-CD4 antibody (TNX-355) and enfuvirtide (T-20) [J]. Antimicrob Agents Chemother, 2006, 50: 2231-2233. (Pubitemid 43807552)
9. Chou TC. The median-effect principle and the combination index for quantitation of synergism and antagonism [M]//Chou TC, Rideout DC (editor). Synergism and Antagonism in Chemothrapy. San Diego: Academic Press, 1991.
10. Kostova I. Coumarins as inhibitors of HIV reverse transcriptase [J]. Curr HIV Res, 2006, 4: 347-363. (Pubitemid 44054830)
11. Lunney EA, Hagen SE, Domagala JM, et al. A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs [J]. J Med Chem, 1994, 37: 2664-2677.
12. Kashman Y, Gustafson KR, Fuller RW, et al. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum [J]. J Med Chem, 1992, 35: 2735-2743.