Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 2, 2011, Pages 215-224

  Yamaoka, Nagahisa ^a   Kodama, Hidehiko ^a   Izuhara, Yuko ^b   Miyata, Toshio ^b   Meguro, Kanji ^a  

^a Technology Department / Yonezawa Hamari Chemicals Ltd 2 4300 18   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Inhibitor; N acylanthranilic acid derivative; Plasminogen activator inhibitor 1; Structure activity relationship; TM5275

Indexed keywords

2 [[[2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL] 2 OXOETHOXY]ACETYL]AMINO] 4 (PYRIDIN 4 YL)BENZOIC ACID; 2 [[[2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL] 2 OXOETHOXY]ACETYL]AMINO] 5 (PYRIDIN 3 YL)BENZOIC ACID; 5 CHLORO 2 [[6 [(4 CHLOROPHENYL)AMINO] 6 OXOHEXANOYL]AMINO]BENZOIC ACID; 5 CHLORO 2 [[[1 [2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL] 2 OXOETHYLY]CYCLOHEXYL]ACETYL]AMINO]BENZOIC ACID; 5 CHLORO 2 [[[2 [(4 CHLORPHENYL)AMINO] 2 OXOETHOXY]ACETYL]AMINO]BENZOIC ACID; 5 CHLORO 2 [[[2 [(DIPHENYL)AMINO] 2 OXOETHOXY]ACETYL]AMINO]BENZOIC ACID; 5 CHLORO 2 [[[2 OXO 2 (4 PHENYLPIPERIDIN 1 YL)ETHOXY]ACETYL]AMINO]BENZOIC ACID; ALEPLASININ; ANTIFIBRINOLYTIC AGENT; DIAPLASININ; PLASMINOGEN ACTIVATOR INHIBITOR 1; SODIUM 2 [[6 [[3 (TERT BUTOXYCARBONYL) 4 PHENYLTHIOPHEN 2 YL]AMINO] 6 OXOHEXANOYL]AMINO] 5 CHLOROBENZOATE; SODIUM 2 [[[2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL] 2 OXOETHOXY]ACETYL]AMINO] 5 (2 METHYLPROPYL)BENZOATE; SODIUM 5 BENZYL 2 [[[2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL] 2 OXOETHOXY]ACETYL]AMINO]BENOZOATE; SODIUM 5 CHLORO 2 [[[2 (4,4 DIPHENYLPIPERIDIN 1 YL) 2 OXOETHOXY]ACETYL]AMINO]BENZOATE; SODIUM 5 CHLORO 2 [[[2 [4 (DIPHENYLMETHYL)PIPERAZIN 1 YL] 2 OXOETHOXY]ACETYL]AMINO]BENZOATE; TIPLASININ; TM 5001; TM 5007; UNCLASSIFIED DRUG;

ARTICLE; DRUG ABSORPTION; DRUG SYNTHESIS; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTHRANILIC ACIDS; HUMANS; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79551489999     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.215     Document Type: Article

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