Effects of low doses of intracerebroventricular 6-OHDA on the levels of monoaminergic neurotransmitters in rat brain structures

Pharmacological Reports

Volumn 62, Issue 6, 2010, Pages 1225-1230

  Sadakierska Chudy, Anna ^a   Haduch, Anna ^a   Gołembiowska, Krystyna ^a   Daniel, Władysława A ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

6 OHDA; Brain structures; Dopamine; Intracerebroventricular injection; Noradrenaline; Serotonin

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; CYTOCHROME P450; DOPAMINE; HOMOVANILLIC ACID; LIVER PROTEIN; NORADRENALIN; OXIDOPAMINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC INNERVATION; BRAIN DAMAGE; BRAIN REGION; CONTROLLED STUDY; DISEASE SEVERITY; DOPAMINE BRAIN LEVEL; EXPERIMENTAL MODEL; FUNCTIONAL MORPHOLOGY; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; HYPOTHALAMUS LESION; LATERAL BRAIN VENTRICLE; MALE; METABOLITE; MONOAMINE NERVE CELL; NEUROTRANSMITTER UPTAKE; NONHUMAN; NORADRENALIN BRAIN LEVEL; NORADRENERGIC SYSTEM; NUCLEUS ACCUMBENS; PROTEIN EXPRESSION; RAT; SEROTONIN BRAIN LEVEL;

EID: 79551484585     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(10)70386-8     Document Type: Article

References (16)

1. Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM: Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol, 2001, 65, 135-172.
2. Breese GR, Traylor TD: Depletion of noradrenaline and dopamine by 6-hydroxydopamine. Br J Pharmacol, 1971, 42, 88-99.
3. Glinka Y, Gassen M, Youdim MB: Mechanism of 6-hydroxydopamine neurotoxicity. J Neural Transm Suppl, 1997, 50, 55-66.
4. Gołembiowska K, Dziubina A, Kowalska M, Kamińska K: Paradoxical effect of adenosine receptor ligands on hydroxyl radical generation by L-DOPA in the rat striatum. Pharmacol Rep, 2008, 60, 319-330.
5. Herman ZS, Kmieciak-Kołada K, Brus R: Behaviour of rats and biogenic amine level in brain after 6-hydroxydopaminie. Psychopharmacologia, 1972, 24, 407-416.
6. Karoum F, Chrapusta SJ, Egan MF, Wyatt RJ: Absence of 6-hydroxydopamine in the rat brain after treatment with stimulants and other dopaminenergic agents: a mass fragmentographic study. J Neurochem, 1993, 61, 1369-1375.
7. KomiyamaY, Mori T, Okuda K, Munakata M, Murakami T, Masuda M, Goto A et al.: Effect of intracerebroventricular administration of 6-hydroxydopamine on ouabain-like immunoreactivity in plasma and the hypothalamo-pituitary axis in rats. J Hypertens, 1996, 14, 447-452.
8. Kumar R, Agarwal ML, Seth PK: Free radical-generated neurotoxicity of 6-hydroxydopamine. J Neurochem, 1995, 64, 1701-1707.
9. Luthman J, Fredriksson A, Sundström E, Jonsson G, Archer T: Selective lesion of central dopamine or noradrenaline neuron systems in the neonatal rat: Motor behavior and monoamine alteration at adult stage. Behav Brain Res, 1989, 33, 267-227.
10. Reader TA, Gauthier P: Catecholamines and serotonin in the rat central nervous system after 6-OHDA, 5,7-DHT and p-CPA. J Neural Transm, 1984, 59, 207-227.
11. Rodriquez M, Barroso-Chinea P, Abdala P, Obeso J, González- Hernández T: Dopamine cell degeneration induced by intraventricular administration of 6-hydroxydopamine in the rat: similarities with cell loss. Exp Neurol, 2002, 169, 163-181.
12. Samanin R, Bernasconi S: Effects of intraventricularly induced 6-OHDA dopamine or midbrain raphe lesion on morphine analgesia in rats. Psychopharmacology, 1972, 25, 175-182.
13. Soto-Otero R, Mendez-Alvarez E, Hermida-Ameijeiras A, Munoz-Patino AM, Labendeira-Garcia JL: Auto-oxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem, 2000, 77, 1605-1612.
14. Uretsky NJ, Iversen LL: Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. J Neurochem, 1970, 17, 269-278.
15. Vetulani J, Reichenberg K, Wiszniowska G: The ineffectivness of desipramine pretreatment on behavioral effects of 6-hydroxydopamine in nialamide-pretreated rats. Psychopharmacologia, 1974, 38, 173-180.
16. Zigmond MJ, Keefe KA: 6-Hydroxydopamine as a tool for studying catechoalmines in adult animals. In: Highly Selective Neurotoxins: Basic and Clinical Applications. Ed. Kostrzewa MR, Humana Press, Totowa, 1998, 75-107.