메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages 22-27

Future therapies for the myeloproliferative neoplasms

Author keywords

Essential thrombocythemia; Jak2 inhibitors; Myelofibrosis; Myeloproliferative neoplasm; Polycythemia vera; Treatment

Indexed keywords

ACETYLSALICYLIC ACID; ANAGRELIDE; ANTIFIBROTIC AGENT; AZD 1480; CYT 387; EVEROLIMUS; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; IMMUNOMODULATING AGENT; INCB 018424; INTERFERON; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; LESTAURTINIB; LY 2784544; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PANOBINOSTAT; PEGINTERFERON ALPHA2A; PHENYLALANINE; POMALIDOMIDE; PROTEIN TYROSINE KINASE; SB 1518; TG 101348; UNCLASSIFIED DRUG; VALINE;

EID: 79551479092     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-010-0068-4     Document Type: Article
Times cited : (6)

References (33)
  • 1
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • 1:CAS:528:DC%2BD1MXps1eit70%3D 10.1182/blood-2009-03-209262 19357394 This key reference addresses the WHO changes in the diagnosis of the MPNs, addressing the neoplastic nature of the illnesses and the current diagnostic criteria
    • JW Vardiman J Thiele DA Arber RD Brunning MJ Borowitz A Porwit, et al. 2009 The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes Blood 114 5 937 951 1:CAS:528:DC%2BD1MXps1eit70%3D 10.1182/blood-2009-03-209262 19357394 This key reference addresses the WHO changes in the diagnosis of the MPNs, addressing the neoplastic nature of the illnesses and the current diagnostic criteria
    • (2009) Blood , vol.114 , Issue.5 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning, R.D.4    Borowitz, M.J.5    Porwit, A.6
  • 3
    • 40049103602 scopus 로고    scopus 로고
    • New insights into the pathogenesis and treatment of chronic myeloproliferative disorders
    • DOI 10.1097/MOH.0b013e3282f3debd, PII 0006275220080300000009
    • RA Mesa 2008 New insights into the pathogenesis and treatment of chronic myeloproliferative disorders Curr Opin Hematol 15 2 121 126 1:CAS:528: DC%2BD1cXjslWitrc%3D 10.1097/MOH.0b013e3282f3debd 18300758 (Pubitemid 351323152)
    • (2008) Current Opinion in Hematology , vol.15 , Issue.2 , pp. 121-126
    • Mesa, R.A.1
  • 4
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • 1:CAS:528:DC%2BD1MXktFWnsLc%3D 10.1182/blood-2008-07-170449 18988864 This article presents the most comprehensive prognostic criteria for myelofibrosis ever published, based on high-quality analysis of over 1,000 patients
    • F Cervantes B Dupriez A Pereira, et al. 2009 New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment Blood 113 13 2895 2901 1:CAS:528:DC%2BD1MXktFWnsLc%3D 10.1182/blood-2008-07-170449 18988864 This article presents the most comprehensive prognostic criteria for myelofibrosis ever published, based on high-quality analysis of over 1,000 patients
    • (2009) Blood , vol.113 , Issue.13 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3
  • 6
    • 33947208087 scopus 로고    scopus 로고
    • Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
    • DOI 10.1182/blood-2006-08-042515
    • R Landolfi L Di Gennaro T Barbui V De Stefano G Finazzi R Marfisi, et al. 2007 Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera Blood 109 6 2446 2452 1:CAS:528:DC%2BD2sXnslygsL0%3D 10.1182/blood-2006-08-042515 17105814 (Pubitemid 46425887)
    • (2007) Blood , vol.109 , Issue.6 , pp. 2446-2452
    • Landolfi, R.1    Di Gennaro, L.2    Barbui, T.3    De Stefano, V.4    Finazzi, G.5    Marfisi, R.6    Tognoni, G.7    Marchioli, R.8
  • 8
    • 20444502966 scopus 로고    scopus 로고
    • Risk-adapted therapy in essential thrombocythemia and polycythemia vera
    • DOI 10.1016/j.blre.2005.01.001, PII S0268960X05000020
    • G Finazzi T Barbui 2005 Risk-adapted therapy in essential thrombocythemia and polycythemia vera Blood Rev 19 5 243 252 10.1016/j.blre.2005.01.001 15963833 (Pubitemid 40814453)
    • (2005) Blood Reviews , vol.19 , Issue.5 , pp. 243-252
    • Finazzi, G.1    Barbui, T.2
  • 11
    • 54049141336 scopus 로고    scopus 로고
    • Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
    • 1:CAS:528:DC%2BD1cXht1OmtbfE 10.1182/blood-2008-03-143537 18650451 This is the first report of molecular remission in patients with PV with the use of interferon
    • JJ Kiladjian B Cassinat S Chevret P Turlure N Cambier M Roussel, et al. 2008 Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera Blood 112 8 3065 3072 1:CAS:528:DC%2BD1cXht1OmtbfE 10.1182/blood-2008-03-143537 18650451 This is the first report of molecular remission in patients with PV with the use of interferon
    • (2008) Blood , vol.112 , Issue.8 , pp. 3065-3072
    • Kiladjian, J.J.1    Cassinat, B.2    Chevret, S.3    Turlure, P.4    Cambier, N.5    Roussel, M.6
  • 12
    • 77953492278 scopus 로고    scopus 로고
    • Pegylated Interferon-ALFA-2A (PEG-IFN-α-2A; PEGASYS) Therapy Renders High Clinical and Molecular Response Rates in Patients with Essential Thrombocythemia (ET) and Polycythemia VERA (PV) [abstract]
    • Quintas-Cardama A, Kantarjian HM, Garcia-Manero G, Cortes J, Richie MA, Borthakur G, et al.: Pegylated Interferon-ALFA-2A (PEG-IFN-α-2A; PEGASYS) Therapy Renders High Clinical and Molecular Response Rates in Patients with Essential Thrombocythemia (ET) and Polycythemia VERA (PV) [abstract]. ASH Annual Meeting Abstracts 2008, 112(11):658.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , Issue.11 , pp. 658
    • Quintas-Cardama, A.1    Kantarjian, H.M.2    Garcia-Manero, G.3    Cortes, J.4    Ma, R.5    Borthakur, G.6
  • 13
    • 67049109249 scopus 로고    scopus 로고
    • How i treat symptomatic splenomegaly in patients with myelofibrosis
    • 1:CAS:528:DC%2BD1MXntVertLg%3D 10.1182/blood-2009-02-195974 19332765
    • RA Mesa 2009 How I treat symptomatic splenomegaly in patients with myelofibrosis Blood 113 22 5394 5400 1:CAS:528:DC%2BD1MXntVertLg%3D 10.1182/blood-2009-02-195974 19332765
    • (2009) Blood , vol.113 , Issue.22 , pp. 5394-5400
    • Mesa, R.A.1
  • 14
    • 67650766311 scopus 로고    scopus 로고
    • Erythropoiesis stimulating agents have limited therapeutic activity in transfusion-dependent patients with primary myelofibrosis regardless of serum erythropoietin level
    • 1:CAS:528:DC%2BD1MXpvFehsLo%3D 10.1111/j.1600-0609.2009.01266.x 19366369
    • J Huang A Tefferi 2009 Erythropoiesis stimulating agents have limited therapeutic activity in transfusion-dependent patients with primary myelofibrosis regardless of serum erythropoietin level Eur J Haematol 83 2 154 155 1:CAS:528:DC%2BD1MXpvFehsLo%3D 10.1111/j.1600-0609.2009.01266.x 19366369
    • (2009) Eur J Haematol , vol.83 , Issue.2 , pp. 154-155
    • Huang, J.1    Tefferi, A.2
  • 15
    • 18844467494 scopus 로고    scopus 로고
    • Danazol treatment of idiopathic myelofibrosis with severe anemia
    • 1:CAS:528:DC%2BD3cXmsVGgsrc%3D 10870115
    • F Cervantes JC Hernandez-Boluda A Alvarez E Nadal E Montserrat 2000 Danazol treatment of idiopathic myelofibrosis with severe anemia Haematologica 85 6 595 599 1:CAS:528:DC%2BD3cXmsVGgsrc%3D 10870115
    • (2000) Haematologica , vol.85 , Issue.6 , pp. 595-599
    • Cervantes, F.1    Hernandez-Boluda, J.C.2    Alvarez, A.3    Nadal, E.4    Montserrat, E.5
  • 17
    • 0034176014 scopus 로고    scopus 로고
    • Splenectomy in myelofibrosis with myeloid metaplasia: A single-institution experience with 223 patients
    • 1:CAS:528:DC%2BD3cXitFeitr4%3D 10733489
    • A Tefferi RA Mesa DM Nagorney G Schroeder MN Silverstein 2000 Splenectomy in myelofibrosis with myeloid metaplasia: a single-institution experience with 223 patients Blood 95 7 2226 2233 1:CAS:528:DC%2BD3cXitFeitr4%3D 10733489
    • (2000) Blood , vol.95 , Issue.7 , pp. 2226-2233
    • Tefferi, A.1    Mesa, R.A.2    Nagorney, D.M.3    Schroeder, G.4    Silverstein, M.N.5
  • 18
    • 0031784441 scopus 로고    scopus 로고
    • Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia
    • DOI 10.1046/j.1365-2141.1998.00998.x
    • MA Elliott MG Chen MN Silverstein A Tefferi 1998 Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia British Journal of Haematology. 103 2 505 511 1:STN:280:DyaK1M%2FktlKhug%3D%3D 10.1046/j.1365-2141.1998.00998.x 9827926 (Pubitemid 28522460)
    • (1998) British Journal of Haematology , vol.103 , Issue.2 , pp. 505-511
    • Elliott, M.A.1    Chen, M.G.2    Silverstein, M.N.3    Tefferi, A.4
  • 20
    • 12944268972 scopus 로고    scopus 로고
    • Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia
    • DOI 10.1111/j.1600-0609.2004.00370.x
    • LN Faoro A Tefferi RA Mesa 2005 Long-term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with myeloid metaplasia Eur J Haematol 74 2 117 120 1:CAS:528:DC%2BD2MXitVGnsL0%3D 10.1111/j.1600-0609.2004. 00370.x 15654901 (Pubitemid 40175314)
    • (2005) European Journal of Haematology , vol.74 , Issue.2 , pp. 117-120
    • Faoro, L.N.1    Tefferi, A.2    Mesa, R.A.3
  • 21
    • 73949084969 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: A prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    • 10.1182/blood-2009-07-234880 19812383 This is the most comprehensive prospective trial of allogeneic stem cell transplantation in myelofibrosis
    • N Kroger E Holler G Kobbe M Bornhauser R Schwerdtfeger H Baurmann, et al. 2009 Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation Blood 114 26 5264 5270 10.1182/blood-2009-07-234880 19812383 This is the most comprehensive prospective trial of allogeneic stem cell transplantation in myelofibrosis
    • (2009) Blood , vol.114 , Issue.26 , pp. 5264-5270
    • Kroger, N.1    Holler, E.2    Kobbe, G.3    Bornhauser, M.4    Schwerdtfeger, R.5    Baurmann, H.6
  • 22
    • 77956696835 scopus 로고    scopus 로고
    • Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
    • 1:CAS:528:DC%2BC3cXhtFOltrjJ 10.1056/NEJMoa1002028 20843246 This is the first major report of the efficacy of a JAK2 inhibitor in patients with myelofibrosis
    • S Verstovsek H Kantarjian RA Mesa AD Pardanani J Cortes-Franco DA Thomas, et al. 2010 Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis N Engl J Med 363 12 1117 1127 1:CAS:528:DC%2BC3cXhtFOltrjJ 10.1056/NEJMoa1002028 20843246 This is the first major report of the efficacy of a JAK2 inhibitor in patients with myelofibrosis
    • (2010) N Engl J Med , vol.363 , Issue.12 , pp. 1117-1127
    • Verstovsek, S.1    Kantarjian, H.2    Mesa, R.A.3    Pardanani, A.D.4    Cortes-Franco, J.5    Thomas, D.A.6
  • 23
    • 71949109403 scopus 로고    scopus 로고
    • INCB018424, a Selective JAK1/2 Inhibitor, Significantly Improves the Compromised Nutritional Status and Frank Cachexia in Patients with Myelofibrosis (MF)
    • RA Mesa S Verstovsek HM Kantarjian AD Pardanani S Friedman R Newton, et al. 2008 INCB018424, a Selective JAK1/2 Inhibitor, Significantly Improves the Compromised Nutritional Status and Frank Cachexia in Patients with Myelofibrosis (MF) Blood 112 11 1760
    • (2008) Blood , vol.112 , Issue.11 , pp. 1760
    • Mesa, R.A.1    Verstovsek, S.2    Kantarjian, H.M.3    Pardanani, A.D.4    Friedman, S.5    Newton, R.6
  • 24
    • 79551478191 scopus 로고    scopus 로고
    • Validation of the Serial Use of the Myelofibrosis Symptom Assessment Form (MF-SAF) for Measuring Symptomatic Improvement: Performance in 86 Myelofibrosis Patients on INCB018424 Clinical Trial [abstract]
    • RA Mesa H Kantarjian A Tefferi, et al. 2009 Validation of the Serial Use of the Myelofibrosis Symptom Assessment Form (MF-SAF) for Measuring Symptomatic Improvement: Performance in 86 Myelofibrosis Patients On INCB018424 Clinical Trial [abstract] Blood 114 22 a3917
    • (2009) Blood , vol.114 , Issue.22 , pp. 3917
    • Mesa, R.A.1    Kantarjian, H.2    Tefferi, A.3
  • 25
    • 77950637099 scopus 로고    scopus 로고
    • A Phase i Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2V617F Allele Burden [abstract]
    • AD Pardanani R Jason M Gotlib M Catriona Jamieson M Jorge Cortes M Moshe Talpaz M Richard Stone, et al. 2009 A Phase I Evaluation of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis: Clinical Response Is Accompanied by Significant Reduction in JAK2V617F Allele Burden [abstract] Blood 114 22 a755
    • (2009) Blood , vol.114 , Issue.22 , pp. 755
    • Pardanani, A.D.1    Jason, R.2    Gotlib, M.3    Catriona Jamieson, M.4    Jorge Cortes, M.5    Moshe Talpaz, M.6    Richard Stone, M.7
  • 26
    • 77953198579 scopus 로고    scopus 로고
    • Phase i Dose-Escalation Trial of SB1518, a Novel JAK2/FLT3 Inhibitor, in Acute and Chronic Myeloid Diseases, Including Primary or Post-Essential Thrombocythemia/Polycythemia Vera Myelofibrosis [abstract]
    • S Verstovsek O Odenike B Scott, et al. 2009 Phase I Dose-Escalation Trial of SB1518, a Novel JAK2/FLT3 Inhibitor, in Acute and Chronic Myeloid Diseases, Including Primary or Post-Essential Thrombocythemia/Polycythemia Vera Myelofibrosis [abstract] Blood 114 22 a3905
    • (2009) Blood , vol.114 , Issue.22 , pp. 3905
    • Verstovsek, S.1    Odenike, O.2    Scott, B.3
  • 27
    • 77950630883 scopus 로고    scopus 로고
    • A Multicenter, Open Label Phase I/II Study of CEP701 (Lestaurtinib) in Adults with Myelofibrosis; A Report on Phase I: A Study of the Myeloproliferative Disorders Research Consortium (MPD-RC) [abstract]
    • E Hexner JD Goldberg JT Prchal, et al. 2009 A Multicenter, Open Label Phase I/II Study of CEP701 (Lestaurtinib) in Adults with Myelofibrosis; a Report On Phase I: A Study of the Myeloproliferative Disorders Research Consortium (MPD-RC) [abstract] Blood 114 22 a754
    • (2009) Blood , vol.114 , Issue.22 , pp. 754
    • Hexner, E.1    Goldberg, J.D.2    Prchal, J.T.3
  • 28
    • 75449087842 scopus 로고    scopus 로고
    • Phase1/-2 study of pomalidomide in myelofibrosis
    • 1:CAS:528:DC%2BC3cXitlKmsrg%3D 20052748
    • RA Mesa AD Pardanani K Hussein W Wu S Schwager MR Litzow, et al. 2010 Phase1/-2 study of pomalidomide in myelofibrosis Am J Hematol 85 2 129 130 1:CAS:528:DC%2BC3cXitlKmsrg%3D 20052748
    • (2010) Am J Hematol , vol.85 , Issue.2 , pp. 129-130
    • Mesa, R.A.1    Pardanani, A.D.2    Hussein, K.3    Wu, W.4    Schwager, S.5    Litzow, M.R.6
  • 29
    • 77950917500 scopus 로고    scopus 로고
    • A Phase i Study of LBH589, a Novel Histone Deacetylase Inhibitor in Patients with Primary Myelofibrosis (PMF) and Post-Polycythemia/Essential Thrombocythemia Myelofibrosis (Post-PV/ET MF) [abstract]
    • J Mascarenhas X Wang A Rodriguez, et al. 2009 A Phase I Study of LBH589, a Novel Histone Deacetylase Inhibitor in Patients with Primary Myelofibrosis (PMF) and Post-Polycythemia/Essential Thrombocythemia Myelofibrosis (Post-PV/ET MF) [abstract] Blood 114 22 a308
    • (2009) Blood , vol.114 , Issue.22 , pp. 308
    • Mascarenhas, J.1    Wang, X.2    Rodriguez, A.3
  • 30
    • 77950917641 scopus 로고    scopus 로고
    • RAD001, an inhibitor of mTOR, shows clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia myelofibrosis (PPV/PET MF) [abstract]
    • AM Vannucchi P Guglielmelli E Gattoni, et al. 2009 RAD001, an inhibitor of mTOR, shows clinical activity in a phase I/II study in patients with primary myelofibrosis (PMF) and post polycythemia vera/essential thrombocythemia myelofibrosis (PPV/PET MF) [abstract] Blood 114 22 a307
    • (2009) Blood , vol.114 , Issue.22 , pp. 307
    • Vannucchi, A.M.1    Guglielmelli, P.2    Gattoni, E.3
  • 31
    • 77953225534 scopus 로고    scopus 로고
    • A phase 2 study of INCB018424, an oral, selective JAK1/JAK2 inhibitor, in patients with advanced polycythemia vera (PV) and essential thrombocythemia (ET) refractory to hydroxyurea [abstract]
    • First report of a JAK2 inhibitor in patients with ET and PV
    • S Verstovsek F Passamonti A Rambaldi, et al. 2009 A phase 2 study of INCB018424, an oral, selective JAK1/JAK2 inhibitor, in patients with advanced polycythemia vera (PV) and essential thrombocythemia (ET) refractory to hydroxyurea [abstract] Blood 114 22 a311 First report of a JAK2 inhibitor in patients with ET and PV
    • (2009) Blood , vol.114 , Issue.22 , pp. 311
    • Verstovsek, S.1    Passamonti, F.2    Rambaldi, A.3
  • 32
    • 76949105624 scopus 로고    scopus 로고
    • An open-label study of CEP-701 in patients with JAK2 V617F-positive PV and ET: Update of 39 enrolled patients [abstract]
    • AR Moliterno E Hexner GJ Roboz, et al. 2009 An open-label study of CEP-701 in patients with JAK2 V617F-positive PV and ET: update of 39 enrolled patients [abstract] Blood 114 22 a753
    • (2009) Blood , vol.114 , Issue.22 , pp. 753
    • Moliterno, A.R.1    Hexner, E.2    Roboz, G.J.3
  • 33
    • 73949090770 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera
    • 1:CAS:528:DC%2BD1MXhsFKkt7vP 10.1200/JCO.2009.23.6075 19826111
    • A Quintas-Cardama H Kantarjian T Manshouri R Luthra Z Estrov S Pierce, et al. 2009 Pegylated interferon alfa-2a yields high rates of hematologic and molecular response in patients with advanced essential thrombocythemia and polycythemia vera J Clin Oncol 27 32 5418 5424 1:CAS:528:DC%2BD1MXhsFKkt7vP 10.1200/JCO.2009.23.6075 19826111
    • (2009) J Clin Oncol , vol.27 , Issue.32 , pp. 5418-5424
    • Quintas-Cardama, A.1    Kantarjian, H.2    Manshouri, T.3    Luthra, R.4    Estrov, Z.5    Pierce, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.