IL28B: A new wager in the skyline of hepatitis C virus infection

Digestive and Liver Disease

Volumn 43, Issue 3, 2011, Pages 177-179

  Mangia, Alessandra ^a  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 28B; PEGINTERFERON ALPHA; RIBAVIRIN;

GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS VIRUS; HUMAN; NONHUMAN; NOTE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; VIREMIA;

ANTIVIRAL AGENTS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; INTERFERON ALFA-2B; INTERLEUKINS; POLYETHYLENE GLYCOLS; POLYMORPHISM, SINGLE NUCLEOTIDE; RIBAVIRIN; TREATMENT OUTCOME;

EID: 79551478491     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2010.12.005     Document Type: Note

References (11)

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2. Suppiah V., Maldovam M., Ahlenstiel G., et al. IL 28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Gen 2009, 41:1100-1104.
3. Tanaka Y., Nishida N., Sugiyama M., et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009, 41:1105-1109.
4. Thomas D.L., Thio C.L., Martin M.P., et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009, 461:798-801.
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6. Tillmann H.L., Thompson A., Patel K., et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology 2010, 139:1586-1592.
7. Mangia A., Santoro R., Mottola L., et al. IL28B CCpolymorphism is predictive of spontaneous HCV RNA clearance in patients with thalassemia major. J Hepatol 2010, 52:S452.
8. Guo S.W., Thompson E.A. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992, 48:361-372.
9. Thompson A.J., Muir A., Sulkowski M., et al. IL28B polymorphism improves viral kinetics and is the strongest pre-treatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology 2010, 139:120-129.
10. Mangia A., Thompson A.J., Santoro R., et al. Interleukin-28B polymorphism determines treatment response of patients with hepatitis C genotypes 2 and 3 who do not achieve a rapid virologic response. Gastroenterology 2010, 139:821-827.
11. Stattermayer AF, Stauber R, Hofer H, et al. Impact of IL28B genotype on the early and sustained virologic response in treatment-naïve patients with chronic hepatitis C. Clin Gastroenterol Hepatol; 2010 [published ahead of print].