Metabolic actions could confound advantageous effects of combined angiotensin II receptor and neprilysin inhibition

Hypertension

Volumn 57, Issue 2, 2011, Pages

  Birkenfeld, Andreas L ^a   Adams, Frauke ^a   Schroeder, Christoph ^b   Engeli, Stefan ^b   Jordan, Jens ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR; MEMBRANE METALLOENDOPEPTIDASE; NATRIURETIC PEPTIDE RECEPTOR A;

ADIPOSE TISSUE; BLOOD PRESSURE; ENZYME INHIBITION; HEART LEFT VENTRICLE EJECTION FRACTION; HYPERTENSION; LETTER; LIPID METABOLISM; LIPID OXIDATION; LIPOLYSIS; METABOLISM; PRIORITY JOURNAL;

ADIPOCYTES; ADRENERGIC BETA-AGONISTS; AMINOBUTYRIC ACIDS; ANGIOTENSIN RECEPTOR ANTAGONISTS; ATRIAL NATRIURETIC FACTOR; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART FAILURE; HUMANS; ISOPROTERENOL; LIPOLYSIS; MALE; MIDDLE AGED; NEPRILYSIN; RECEPTORS, ANGIOTENSIN; TETRAZOLES; VENTRICULAR DYSFUNCTION, LEFT;

EID: 79551471674     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.165159     Document Type: Letter

References (5)

1. Ruilope LM, Dukat A, Bohm M, Lacourciere Y, Gong J, Lefkowitz MP. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Lancet. 2010;375:1255-1266.
2. Sengenes C, Zakaroff-Girard A, Moulin A, Berlan M, Bouloumie A, Lafontan M, Galitzky J. Natriuretic peptide-dependent lipolysis in fat cells is a primate specificity. Am J Physiol Regul Integr Comp Physiol. 2002; 283:R257-R265.
3. Birkenfeld AL, Boschmann M, Moro C, Adams F, Heusser K, Franke G, Berlan M, Luft FC, Lafontan M, Jordan J. Lipid Mobilization with Physiological Atrial Natriuretic Peptide Concentrations in Humans. J Clin Endocrinol Metab. 2005;90:3622-3628.
4. Birkenfeld AL, Budziarek P, Boschmann M, Moro C, Adams F, Franke G, Berlan M, Marques MA, Sweep FC, Luft FC, Lafontan M, Jordan J. Atrial natriuretic peptide induces postprandial lipid oxidation in humans. Diabetes. 2008;57:3199-3204.
5. von Haehling S, Doehner W, Anker SD. Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure. Cardiovasc Res. 2007;73:298-309.